Haorong Lu
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View article: Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees
Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees Open
View article: Telomere-to-telomere African wild rice (Oryza longistaminata) reference genome reveals segmental and structural variation
Telomere-to-telomere African wild rice (Oryza longistaminata) reference genome reveals segmental and structural variation Open
Rice (Oryza sativa) is one of the most important staple food crops worldwide, and its wild relatives serve as an important gene pool in its breeding. Compared with cultivated rice species, African wild rice (Oryza longistaminata) has sever…
View article: Unraveling the impact of host genetics and factors on the urinary microbiome in a young population
Unraveling the impact of host genetics and factors on the urinary microbiome in a young population Open
The significance of the urinary microbiome in maintaining health and contributing to disease development is increasingly recognized. However, a comprehensive understanding of this microbiome and its influencing factors remains elusive. Uti…
View article: Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome
Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome Open
View article: Single-nucleus and spatial transcriptome identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees
Single-nucleus and spatial transcriptome identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees Open
Animal behavior is associated with the gene regulatory network (GRN) coordinating gene expression levels in the brain. The eusocial honeybees with natural behavioral plasticity provide an ideal model for studying the relationship between b…
View article: Large-scale genome sequencing of giant pandas improves the understanding of population structure and future conservation initiatives
Large-scale genome sequencing of giant pandas improves the understanding of population structure and future conservation initiatives Open
The extinction risk of the giant panda has been demoted from “endangered” to “vulnerable” on the International Union for Conservation of Nature Red List, but its habitat is more fragmented than ever before, resulting in 33 isolated giant p…
View article: Unraveling the impact of host genetics and factors on the urinary microbiome in a young population
Unraveling the impact of host genetics and factors on the urinary microbiome in a young population Open
The significance of the urinary microbiome in maintaining health and contributing to disease development is increasingly recognized. However, a comprehensive understanding of this microbiome and its influencing factors remains elusive. Uti…
View article: Equus roundworms (Parascaris spp.) are undergoing divergence due to natural and anthropogenic factors
Equus roundworms (Parascaris spp.) are undergoing divergence due to natural and anthropogenic factors Open
The evolution of parasites is often directly affected by the host’s environment or behavior. Studies on the evolution of the same parasites in different hosts are extremely attractive and highly relevant to our understanding of divergence …
View article: A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome
A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome Open
The nasal cavity harbors diverse microbiota that contributes to human health and respiratory diseases. However, whether and to what extent the host genome shapes the nasal microbiome remains largely unknown. Here, by dissecting the human g…
View article: The genome assembly and annotation of the white-lipped tree pit viper Trimeresurus albolabris
The genome assembly and annotation of the white-lipped tree pit viper Trimeresurus albolabris Open
Trimeresurus albolabris, also known as the white-lipped pit viper or white-lipped tree viper, is a highly venomous snake distributed across Southeast Asia and the cause of many snakebite cases. In this study, we report the first whole geno…
View article: The Genome Assembly and Annotation of the White‐ Lipped Tree Pit Viper Trimeresurus albolabris
The Genome Assembly and Annotation of the White‐ Lipped Tree Pit Viper Trimeresurus albolabris Open
Trimeresurus albolabris, also known as the white-lipped pit viper or white-lipped tree viper, is a highly venomous snake distributed across Southeast Asia and the cause of many snakebite cases. In this study, we report the first whole geno…
View article: Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard
Haplotype-resolved and chromosome-scale genomes provide insights into co-adaptation between the Amur tiger and Amur leopard Open
The Amur tiger (Panthera tigris altaica) and Amur leopard (P. pardus orientalis) are two sympatric but competitive apex predators coexisting in the forests of Northeast Asia. They are both highly endangered animals on the planet, and their…
View article: Spatially resolved molecular and cellular atlas of the mouse brain
Spatially resolved molecular and cellular atlas of the mouse brain Open
A comprehensive atlas of genes, cell types, and their spatial distribution across a whole mammalian brain is fundamental for understanding function of the brain. Here, using snRNA-seq and Stereo-seq techniques, we generated a mouse brain a…
View article: Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging Open
Human aging is invariably accompanied by a decline in renal function, a process potentially exacerbated by uremic toxins originating from gut microbes. Based on a registered household Chinese Guangxi longevity cohort ( n = 151), we conduct…
View article: Genome assembly and annotation of the Brown-Spotted Pit viper Protobothrops mucrosquamatus
Genome assembly and annotation of the Brown-Spotted Pit viper Protobothrops mucrosquamatus Open
The Brown-Spotted Pit viper (Protobothrops mucrosquamatus), also known as the Chinese habu, is a widespread and highly venomous snake distributed from Northeastern India to Eastern China. Genomics research can contribute to our understandi…
View article: Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism
Single-nucleus transcriptome inventory of giant panda reveals cellular basis for fitness optimization under low metabolism Open
Background Energy homeostasis is essential for the adaptation of animals to their environment and some wild animals keep low metabolism adaptive to their low-nutrient dietary supply. Giant panda is such a typical low-metabolic mammal exhib…
View article: The Genome Assembly and Annotation of the Brown-Spotted Pit Viper <em>Protobothrops mucrosquamatus</em>
The Genome Assembly and Annotation of the Brown-Spotted Pit Viper <em>Protobothrops mucrosquamatus</em> Open
Brown-Spotted Pit viper (Protobothrops mucrosquamatus), also known as the Chinese habu, is a widespread and highly venomous snake distributed from from northeastern India to eastern China. Genomics research can help provide much insight in…
View article: Genome assembly and annotation of the Sharp-nosed Pit Viper Deinagkistrodon acutus based on next-generation sequencing data
Genome assembly and annotation of the Sharp-nosed Pit Viper Deinagkistrodon acutus based on next-generation sequencing data Open
The study of the currently known >3,000 species of snakes can provide valuable insights into the evolution of their genomes. Deinagkistrodon acutus, also known as Sharp-nosed Pit Viper, one hundred-pacer viper or five-pacer viper, is a ven…
View article: Genome Assembly and Annotation of the Sharp-Nosed Pit Viper Deinagkistrodon acutus Based on Next-Generation Sequencing Data
Genome Assembly and Annotation of the Sharp-Nosed Pit Viper Deinagkistrodon acutus Based on Next-Generation Sequencing Data Open
The study of the currently known >3,000 species of snakes can provide valuable insights into the evolution of their genomes. Deinagkistrodon acutus, also known as Sharp-nosed Pit Viper, one hundred-pacer viper or five-pacer viper, is a …
View article: Large-scale population genomics of Malayan pangolins reveals deep diversification and a new species
Large-scale population genomics of Malayan pangolins reveals deep diversification and a new species Open
Background Archipelagos and oceanic islands often present high percentage of endemism due to rapid speciation. The Malayan pangolin is a species distributing at both mainland (southern Yunnan, China) and oceanic islands via Malayan peninsu…
View article: Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function
Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function Open
The skin is the largest organ in the human body. Various skin environments on its surface constitutes a complex ecosystem. One of the characteristics of the skin micro‐ecosystem is low biomass, which greatly limits a comprehensive identifi…
View article: A genome-wide association study reveals human genetic impact on the nasal microbial diversity, taxa and functions
A genome-wide association study reveals human genetic impact on the nasal microbial diversity, taxa and functions Open
The nasal cavity harbors diverse microbiota that contribute to human health and respiratory diseases. However, whether and to what extent the host genome shapes the nasal microbiome remains largely unknown. Here, by dissecting the human ge…
View article: Genetic Diversity and Population Structure Analysis of Hollyhock (Alcea rosea Cavan) Using High-Throughput Sequencing
Genetic Diversity and Population Structure Analysis of Hollyhock (Alcea rosea Cavan) Using High-Throughput Sequencing Open
Hollyhock (Alcea rosea (Linn). Cavan) is an herbaceous flowering plant with significant applications in urban greening, soil remediation, and traditional medicine. However, its genetic diversity and molecular characteristics at the populat…
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Table of Contents Open
View article: Population genomics reveals extensive inbreeding and purging of mutational load in wild Amur tigers
Population genomics reveals extensive inbreeding and purging of mutational load in wild Amur tigers Open
The inbreeding is a big threat for the persistence of genetic diversity in small and isolated populations of endangered species. The homozygous genome could exacerbate inbreeding depression by introducing homozygous deleterious alleles in …
View article: Data from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
Data from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA sequencing, T-cell receptor (TCR) sequencing, and multiplexed immunof…
View article: Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma Open
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
View article: Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma Open
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
View article: Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma Open
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
View article: Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma Open
Supplementary Table from Geospatial Immune Heterogeneity Reflects the Diverse Tumor–Immune Interactions in Intrahepatic Cholangiocarcinoma