Hui Dong
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View article: Glymphatic dysfunction in amyotrophic lateral sclerosis: a multimodal MRI investigation of brain-CSF functional and structural dynamics
Glymphatic dysfunction in amyotrophic lateral sclerosis: a multimodal MRI investigation of brain-CSF functional and structural dynamics Open
Background Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration and glial activation. The coupling of global blood oxygen level-dependent (gBOLD) signals with cerebrospinal fluid (CSF) inflow dynami…
View article: Immunohistochemistry in intrahepatic cholangiocarcinoma: histological subtyping and drug selection
Immunohistochemistry in intrahepatic cholangiocarcinoma: histological subtyping and drug selection Open
Introduction Since the release of the World Health Organization ( WHO ) Classification of Tumours-Digestive System Tumours in 2019, the pathology of intrahepatic cholangiocarcinoma (iCCA) has entered an era of integrated diagnosis, encompa…
View article: Development and validation of a predictive model for depression risk in patients with amyotrophic lateral sclerosis
Development and validation of a predictive model for depression risk in patients with amyotrophic lateral sclerosis Open
Introduction Depression is a severe neuropsychiatric manifestation in patients with amyotrophic lateral sclerosis (ALS), substantially impacting their quality of life and exacerbating caregiver burden, due to the need for different approac…
View article: Promoter Analysis and Expression Patterns of the YABBY Transcription Factor Family in Cassava (<i>Manihot esculenta</i>) under Various Environmental Conditions
Promoter Analysis and Expression Patterns of the YABBY Transcription Factor Family in Cassava (<i>Manihot esculenta</i>) under Various Environmental Conditions Open
The YABBY transcription factor (TF) family is a group of plant-specific proteins characterized by a unique structure comprised of a C2C2 zinc finger domain and a helix-loop-helix YABBY domain. These TFs play crucial roles in regulating var…
View article: Claudin18.2 expression in gallbladder cancer correlates with immune activation and a favourable prognosis
Claudin18.2 expression in gallbladder cancer correlates with immune activation and a favourable prognosis Open
Aims Gallbladder carcinoma (GBC) is frequently diagnosed and treated in advanced stages and has a poor prognosis. Recent studies have identified claudin18.2 (CLDN18.2) as a promising target in digestive system cancer. In this study, we aim…
View article: Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes
Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes Open
The influence of tertiary lymphoid structures (TLSs) on disease progression and the response to immunotherapy in head and neck squamous cell carcinoma (HNSCC) is well established, yet the heterogeneity among these structures remains largel…
View article: Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration
Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration Open
Osteosarcoma, a primary malignant bone tumor originating from mesenchymal cells, is the most prevalent bone malignancy in children and adolescents. Current standard treatment involves aggressive surgical resection aimed at maximal tumor re…
View article: Case report: A successful live birth after in vitro fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively
Case report: A successful live birth after in vitro fertilization and embryo transfer in a patient with endometrial cancer who was treated conservatively Open
Objective To describe a patient conceiving with in vitro fertilization and embryo transfer(IVF-ET) after conservative treatment of early stage endometrial cancer. Patient A 31-year-old multiparous woman diagnosed with highly-differentiated…
View article: TRPV4 couples with NCX1 to mediate glucose‐dependent glucagon‐like peptide‐1 release and improve glucose homeostasis
TRPV4 couples with NCX1 to mediate glucose‐dependent glucagon‐like peptide‐1 release and improve glucose homeostasis Open
Although glucose, as a secretagogue of intestinal hormone, can stimulate glucagon‐like peptide 1 (GLP‐1) release, it has not been fully elucidated how glucose triggers GLP‐1 release from enteroendocrine cells (EECs). Here, we investigated …
View article: Advances in the diagnosis and treatment of MET-variant digestive tract tumors
Advances in the diagnosis and treatment of MET-variant digestive tract tumors Open
The receptor tyrosine kinase encoded by the MET gene plays an important role in various cellular processes such as growth, survival, migration and angiogenesis, and its abnormal activation is closely related to the occurrence and developme…
View article: Application of Six Sigma management in prevention of central venous catheter-related bloodstream infection in children with liver transplantation
Application of Six Sigma management in prevention of central venous catheter-related bloodstream infection in children with liver transplantation Open
Objective To investigate the effect of Six Sigma management in prevention of central venous catheter-related bloodstream infections (CLABSI) in children undergoing liver transplantation. Methods From January to September 2021, a total of 2…
View article: Clinical features and CPS1 variants in Chinese patients with carbamoyl phosphate synthetase 1 deficiency
Clinical features and CPS1 variants in Chinese patients with carbamoyl phosphate synthetase 1 deficiency Open
Except for two known variants, all other variants were identified as novel. No hotspot variants were observed among the patients. Our data contribute to expanding the mutation spectrum of CPS1.
View article: Different regulatory mechanisms of Na+/ glucose transport in mouse ileum and jejunum
Different regulatory mechanisms of Na+/ glucose transport in mouse ileum and jejunum Open
Although glucose absorption in the proximal small intestine and its regulatory mechanisms have been extensively studied, less attention has been devoted to regulating glucose absorption in the distal small intestine. Ussing chamber techniq…
View article: Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2<sup>+</sup> axis
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2<sup>+</sup> axis Open
Although exogenous calcitonin gene‑related peptide (CGRP) protects against hyperoxia‑induced lung injury (HILI), the underlying mechanisms remain unclear. The present study attempted to elucidate the molecular mechanism by which CGRP prote…
View article: Pathogenicity, infection process, physiological and biochemical effects of Metarhizium rileyi against Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) larvae
Pathogenicity, infection process, physiological and biochemical effects of Metarhizium rileyi against Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) larvae Open
Background Metarhizium rileyi is an important entomopathogenic fungus which has a wide range of host pests. In this work, the virulence of M. rileyi EFNL-08 against 3rd instar larvae of the fall armyworm, Spodoptera frugiperda (J.E. Smith)…
View article: STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells
STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells Open
Retinoid-related orphan receptor gamma t (RORγt) is the lineage-specific transcription factor for T helper 17 (Th17) cells. Our previous study demonstrated that STAT3 likely participates in the activation of RORCE2 (a novel enhancer of the…
View article: RETRACTED: A comprehensive study on the risk factors and pathogen analysis of postoperative wound infections following caesarean section procedures
RETRACTED: A comprehensive study on the risk factors and pathogen analysis of postoperative wound infections following caesarean section procedures Open
Postoperative wound infections (PWIs), a subtype of surgical site infections, are a significant concern for patients undergoing caesarean sections (C‐sections). Understanding risk factors and pathogen profiles can greatly assist in early d…
View article: A Grading System of Microvascular Invasion for Patients with Hepatocellular Carcinoma Undergoing Liver Resection with Curative Intent: A Multicenter Study
A Grading System of Microvascular Invasion for Patients with Hepatocellular Carcinoma Undergoing Liver Resection with Curative Intent: A Multicenter Study Open
This MVI grading system could precisely evaluate prognosis of HCC patients after liver resection with curative intent and it could be employed in routine pathological reports. The severity of MVI from both adjacent and distant from tumor b…
View article: ACTB may serve as a predictive marker for the efficacy of lenvatinib in patients with HBV-related early-stage hepatocellular carcinoma following partial hepatectomy: a retrospective cohort study
ACTB may serve as a predictive marker for the efficacy of lenvatinib in patients with HBV-related early-stage hepatocellular carcinoma following partial hepatectomy: a retrospective cohort study Open
In patients with tumors treated with lenvatinib, low ACTB expression can predict a lower risk of recurrence. The validation of this potential biomarker in independent cohorts is necessary prior to its implementation for precision treatment…
View article: Clinical features and ALDH5A1 gene findings in 13 Chinese cases with succinic semialdehyde dehydrogenase deficiency
Clinical features and ALDH5A1 gene findings in 13 Chinese cases with succinic semialdehyde dehydrogenase deficiency Open
Background and aims: To investigate the clinical features, ALDH5A1gene variations, treatment, and prognosis of patients with succinic semialdehyde dehydrogenase (SSADH) deficiency. Materials and methods: This retrospective study evaluated …
View article: Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma (2022 version)
Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma (2022 version) Open
Intrahepatic cholangiocarcinoma (iCCA) can originate from the large bile duct group (segment bile ducts and area bile ducts), small bile duct group (septal bile ducts and interlobular bile ducts), and terminal bile duct group (bile ductule…
View article: Divergent roles of estrogen receptor subtypes in regulating estrogen-modulated colonic ion transports and epithelial repair
Divergent roles of estrogen receptor subtypes in regulating estrogen-modulated colonic ion transports and epithelial repair Open
Although it was described previously for estrogen (E2) regulation of intestinal epithelial Cl- and HCO3- secretion in sex difference, almost nothing is known about the roles of estrogen receptor (ER) subtypes in regulating E2-modulated epi…
View article: Cl− induces endothelium-dependent mesenteric arteriolar vasorelaxation through the NKCC1/TRPV4/NCX axis
Cl− induces endothelium-dependent mesenteric arteriolar vasorelaxation through the NKCC1/TRPV4/NCX axis Open
Cl- induces a pure EDH-mediated vasorelaxation of mesenteric arteries through activation of endothelial NKCC1/TRPV4/NCX axis. We have provided a novel insight into the role of Cl--induced vasorelaxation via EDH mechanism.