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View article: A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass
A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass Open
Antimicrobial peptides (AMPs) represent an evolutionarily conserved component of innate immunity with broad-spectrum antimicrobial and antiviral activities. However, the antiviral potential of fish-specific piscidins against emerging aquat…
View article: Air quality prediction based on factor analysis combined with Transformer and CNN-BILSTM-ATTENTION models
Air quality prediction based on factor analysis combined with Transformer and CNN-BILSTM-ATTENTION models Open
View article: Does Greater Independence Lead to Increased Efficiency? Research on the Impact of R&D Independence on Innovation in Business Groups
Does Greater Independence Lead to Increased Efficiency? Research on the Impact of R&D Independence on Innovation in Business Groups Open
This study investigates the influence of research and development (R&D) independence on innovation within business groups (BGs), focusing on the R&D subsidiary as the research lens. The findings indicate that the R&D subsidiary enhances bo…
View article: Optimized design of voltage control rules for distributed energy sources at substation inverter interfaces
Optimized design of voltage control rules for distributed energy sources at substation inverter interfaces Open
Aiming at the voltage control problem of inverter-interfaced distributed energy resources in microgrid systems, this paper proposes an optimized design scheme based on coherent drafting control. The distributed energy is divided into multi…
View article: Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family
Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family Open
2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, con…
View article: Impacts of Built Environment on Urban Vitality in Cultural Districts: A Case Study of Haikou and Suzhou
Impacts of Built Environment on Urban Vitality in Cultural Districts: A Case Study of Haikou and Suzhou Open
In the context of urban development, bridging the gap between urban regeneration and people’s demand for high-quality built environments is a current focus of research. Exploring the vitality of certain kinds of urban districts is imperati…
View article: Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics
Berberine alleviates high-energy and low-protein diet-induced fatty liver hemorrhagic syndrome in laying hens: insights from microbiome and metabolomics Open
Berberine (BBR), a well-known quaternary ammonium alkaloid, is recognized for its ability to prevent and alleviate metabolic disorders because of its anti-oxidative and anti-inflammatory properties. However, the underlying mechanisms of BB…
View article: Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family
Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family Open
2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, con…
View article: Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway
Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway Open
Fatty liver hemorrhagic syndrome (FLHS) in laying hens is a nutritional metabolic disease commonly observed in high-yielding laying hens. Sodium butyrate (NaB) and ferroptosis were reported to contribute to the pathogenesis of fatty liver-…
View article: Praziquantel: A Broad-Spectrum Anthelmintic Compound Unveiling Antiviral Potential Against Msrv, Paving the Way for Novel Applications and Value in Aquaculture
Praziquantel: A Broad-Spectrum Anthelmintic Compound Unveiling Antiviral Potential Against Msrv, Paving the Way for Novel Applications and Value in Aquaculture Open
View article: Structure - Guided to Design of Arctigenin Derivatives Against Infections of <i>Gyrodactylus Kobayashii</i>
Structure - Guided to Design of Arctigenin Derivatives Against Infections of <i>Gyrodactylus Kobayashii</i> Open
View article: Research on the evaluation of the livability of outdoor space in old residential areas based on the AHP and fuzzy comprehensive evaluation: a case study of Suzhou city, China
Research on the evaluation of the livability of outdoor space in old residential areas based on the AHP and fuzzy comprehensive evaluation: a case study of Suzhou city, China Open
China has experienced rapid urban development and renewal. However the infrastructure of many old residential areas (ORAs) more than 20 years old is deteriorating, affecting the living standards of residents and urban vitality. In this pap…
View article: <i>Micropterus salmoides</i> rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner
<i>Micropterus salmoides</i> rhabdovirus enters cells via clathrin-mediated endocytosis pathway in a pH-, dynamin-, microtubule-, rab5-, and rab7-dependent manner Open
Micropterus salmoides rhabdovirus (MSRV) is an important fish pathogen that infects largemouth bass. To date, the entry process for MSRV remains obscure. Here, the dynamic process of MSRV entry and internalization was analyzed using bioche…
View article: Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota
Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota Open
Emerging studies have presented an initial picture of the toxic effects of exposure to environmental micro- and nanoplastics. They have indicated that micro- and nanoplastics may induce toxicity by leading to oxidative stress, energy metab…
View article: In vitro evaluation of the composition and acaricidal efficacy of Urtica fissa leaf ethyl acetate extract against Sarcoptes scabiei mites
In vitro evaluation of the composition and acaricidal efficacy of Urtica fissa leaf ethyl acetate extract against Sarcoptes scabiei mites Open
In veterinary medicine, natural products provide an alternative to chemical agents for mite management. In the present study, the acaricidal efficacy of Urtica fissa leaf ethyl acetate extract against Sarcoptes scabiei mites …
View article: Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases
Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases Open
The innate immune system protects the host from external pathogens and internal damage in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream s…
View article: Taxifolin Inhibits WSSV Infection and Transmission by Increasing the Innate Immune Response in Litopenaeus vannamei
Taxifolin Inhibits WSSV Infection and Transmission by Increasing the Innate Immune Response in Litopenaeus vannamei Open
An outbreak of white spot syndrome virus (WSSV) can hit shrimp culture with a devastating blow, and there are no suitable measures to prevent infection with the virus. In this study, the activity of active molecules from Chinese herbs agai…
View article: Does foreign aid reduce the country's risk of OFDI? The Chinese experience
Does foreign aid reduce the country's risk of OFDI? The Chinese experience Open
Using a sample of 124 countries assisted by China from 2000 to 2019, this paper examines the impact of foreign aid on outward foreign direct investment (OFDI) and the mitigation mechanism of risk. The research finds that, first, foreign ai…
View article: Enhancing Model-Based Anticipatory Traffic Signal Control with Metamodeling and Adaptive Optimization
Enhancing Model-Based Anticipatory Traffic Signal Control with Metamodeling and Adaptive Optimization Open
Traffic signal control is one effective way to alleviate traffic congestion. Anticipatory traffic signal control determines signal settings from a network planning perspective, which takes into account the influence of travelers’ route cho…
View article: Combined radical and ionic approach for the enantioselective synthesis of β-functionalized amines from alcohols
Combined radical and ionic approach for the enantioselective synthesis of β-functionalized amines from alcohols Open
View article: Phylogeny, Evolution, and Transmission Dynamics of Canine and Feline Coronaviruses: A Retro-Prospective Study
Phylogeny, Evolution, and Transmission Dynamics of Canine and Feline Coronaviruses: A Retro-Prospective Study Open
Canine coronavirus (CCoV) and feline coronavirus (FCoV) are endemic in companion animals. Due to their high mutation rates and tendencies of genome recombination, they pose potential threats to public health. The molecular characteristics …
View article: Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication
Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication Open
Spring viremia of carp virus (SVCV) is globally widespread and poses a serious threat to aquatic ecology and aquaculture due to its broad host range. To develop effective agents to control SVCV infection, we selected 16 naturally active sm…
View article: Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells Open
Oxidized low-density lipoprotein (ox-LDL)-induced oxidative injury in vascular endothelial cells is crucial for the progression of cardiovascular diseases, including atherosclerosis. Several flavonoids have been shown cardiovascular protec…
View article: Alphaherpesvirus-vectored vaccines against animal diseases: Current progress
Alphaherpesvirus-vectored vaccines against animal diseases: Current progress Open
Recombinant virus-vectored vaccines are novel agents that can effectively activate specific and nonspecific immunity, are multivalent and multieffective, and have high safety ratings. Animal alphaherpesviruses have a large genome, contain …
View article: I<sub>2</sub>/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea
I<sub>2</sub>/CuO-Catalyzed One-Pot Synthesis of 3-(2-Amino-4-thiazolyl) Coumarin Derivatives from 3-Acetylcoumarins and Thiourea Open
香豆素和噻唑是两类具有广泛的生物活性和药理作用的杂环化合物,合成含噻唑基的香豆素衍生物在药物化学上具有重要的意义.本研究发展了一种方便高效地通过3-乙酰基香豆素和硫脲/N-取代硫脲在I2/CuO催化作用下一锅反应合成3-(2-氨基)-4-噻唑基)香豆素衍生物的方法.所有目标化合物通过核磁共振、红外光谱、质谱分析证实.
View article: Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C–H Amination
Enantioselective Radical Construction of 5-Membered Cyclic Sulfonamides by Metalloradical C–H Amination Open
Both arylsulfonyl and alkylsulfonyl azides can be effectively activated by the cobalt(II) complexes of D2-symmetric chiral amidoporphyrins for enantioselective radical 1,5-C-H amination to stereoselectively construct 5-me…
View article: Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish
Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish Open
View article: Next‐Generation <i>D</i><sub>2</sub>‐Symmetric Chiral Porphyrins for Cobalt(II)‐Based Metalloradical Catalysis: Catalyst Engineering by Distal Bridging
Next‐Generation <i>D</i><sub>2</sub>‐Symmetric Chiral Porphyrins for Cobalt(II)‐Based Metalloradical Catalysis: Catalyst Engineering by Distal Bridging Open
Novel D 2 ‐symmetric chiral amidoporphyrins with alkyl bridges across two chiral amide units on both sides of the porphyrin plane (designated “HuPhyrin”) have been effectively constructed in a modular fashion to permit variation of the bri…
View article: Construction of a recombinant baculovirus expressing swine hepatitis E Virus ORF2 and preliminary research on its immune effect
Construction of a recombinant baculovirus expressing swine hepatitis E Virus ORF2 and preliminary research on its immune effect Open
In the swine hepatitis E virus (HEV), open reading frame 2 (ORF2) is rich in antigenic determinants and neutralizing epitopes that could induce immune protection. We chose the Bac-to-Bac® Baculovirus Expression System to express fragments …