Yan Han
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View article: Biomimetic nanovesicle vaccines derived from dendritic cells sensitized with whole tumor antigens for melanoma immunotherapy
Biomimetic nanovesicle vaccines derived from dendritic cells sensitized with whole tumor antigens for melanoma immunotherapy Open
This study introduces a novel vaccination strategy utilizing the DC-derived nanovesicle vaccine, diA-MADCVac. Systematic studies and experimental validation demonstrate that diA-MADCVac exhibits excellent biocompatibility, ensuring its saf…
View article: Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer
Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer Open
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality. Poor prognostic results in LUAD are frequently associated with KRAS mutations and drug resistance. KRAS mutations can induce STING activation by triggering DNA dama…
View article: Validation of the diagnostic accuracy of the acFibroMASH index for at-risk MASH in patients with metabolic dysfunction-associated steatotic liver disease
Validation of the diagnostic accuracy of the acFibroMASH index for at-risk MASH in patients with metabolic dysfunction-associated steatotic liver disease Open
This study validated the efficacy of the acFibroMASH index in predicting at-risk MASH in a population of MASLD patients, demonstrating comparable performance to that of the FAST. The acFibroMASH index may provide a valuable clinical basis …
View article: Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic Liver Disease
Association Between Percent Body Fat Reduction and Changes of the Metabolic Score for Insulin Resistance in Overweight/Obese People with Metabolic Dysfunction-Associated Steatotic Liver Disease Open
The reduction of PBF was closely associated with changes in METS-IR, indicating that fat loss is an effective method for improving insulin resistance in overweight/obese MASLD patients.
View article: Hierarchical Architectures by Hybridizing Ru Nanoparticles with Nitrogen/Oxygen Dual‐Doped Carbon Nanotubes for Advanced Hydrogen Evolution Reaction Performance
Hierarchical Architectures by Hybridizing Ru Nanoparticles with Nitrogen/Oxygen Dual‐Doped Carbon Nanotubes for Advanced Hydrogen Evolution Reaction Performance Open
Developing highly efficient and stable electrocatalysts is critical for advancing hydrogen evolution reactions (HER) for hydrogen production. Herein, we report a facile approach to fabricating a hierarchical catalyst featuring ruthenium (R…
View article: Association between triglyceride glucose-body mass index and the staging of non-alcoholic steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease
Association between triglyceride glucose-body mass index and the staging of non-alcoholic steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease Open
This study confirms a significant association between insulin resistance and NAFLD, including at-risk NASH and fibrosis staging, as assessed using the TyG-BMI index. TyG-BMI and its associated multivariate models can be valuable noninvasiv…
View article: Genome-wide Identification and Characterization of the LRX Gene Family in Grapevine (Vitis vinifera L.) and Functional Characterization of VvLRX7 in Plant Salt Response
Genome-wide Identification and Characterization of the LRX Gene Family in Grapevine (Vitis vinifera L.) and Functional Characterization of VvLRX7 in Plant Salt Response Open
Background Leucine-rich repeat (LRR) extensins (LRXs), cell wall-localized chimeric extensin proteins, are essential for the development of plants and in their stress resistance. Despite their significance, an extensive genome-wide analysi…
View article: Non-invasive prediction nomogram for predicting significant fibrosis in patients with metabolic-associated fatty liver disease: a cross-sectional study
Non-invasive prediction nomogram for predicting significant fibrosis in patients with metabolic-associated fatty liver disease: a cross-sectional study Open
APRI, FIB-4, and NFS performed poorly predicting significant fibrosis in patients with MAFLD. The new model demonstrated improved diagnostic accuracy and clinical applicability in identifying significant fibrosis in MAFLD.
View article: Current progress in research focused on salt tolerance in Vitis vinifera L.
Current progress in research focused on salt tolerance in Vitis vinifera L. Open
Soil salinization represents an increasingly serious threat to agronomic productivity throughout the world, as rising ion concentrations can interfere with the growth and development of plants, ultimately reducing crop yields and quality. …
View article: High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis
High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis Open
Background: Chronic atrophic gastritis (CAG) is a chronic inflammatory disease and premalignant lesion of gastric cancer. As an antimicrobial peptide, hepcidin can maintain iron metabolic balance and is susceptible to inflammation. Objecti…
View article: Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2
Inhibition Effects and Mechanisms of Marine Polysaccharide PSSD against Herpes Simplex Virus Type 2 Open
Genital herpes is a common sexually transmitted disease mainly caused by herpes simplex virus type 2 (HSV-2), which can increase the risk of HIV transmission and is a major health problem in the world. Thus, it is of great significance to …
View article: Transcriptome Analysis of Detoxification-Related Genes to Solanine in Phthorimaea operculella
Transcriptome Analysis of Detoxification-Related Genes to Solanine in Phthorimaea operculella Open
The files are the raw data of Transcriptome Analysis of Detoxification-Related Genes to Solanine in Phthorimaea operculella.
View article: Identification of fatty acid metabolism–related molecular subtype biomarkers and their correlation with immune checkpoints in cutaneous melanoma
Identification of fatty acid metabolism–related molecular subtype biomarkers and their correlation with immune checkpoints in cutaneous melanoma Open
Purpose Fatty acid metabolism (FAM) affects the immune phenotype in a metabolically dynamic tumor microenvironment (TME), but the use of FAM-related genes (FAMGs) to predict the prognosis and immunotherapy response of cutaneous melanoma (C…
View article: Genome-wide identification and expression of SAUR gene family in peanut (Arachis hypogaea L.) and functional identification of AhSAUR3 in drought tolerance
Genome-wide identification and expression of SAUR gene family in peanut (Arachis hypogaea L.) and functional identification of AhSAUR3 in drought tolerance Open
Background Small auxin-upregulated RNAs ( SAURs ) gene family plays important roles in plant growth, development, and stress responses. However, the function of few SAUR genes is known in the peanut ( Arachis hypogaea L.), one of the world…
View article: Genomic insights into the genetic signatures of selection and seed trait loci in cultivated peanut
Genomic insights into the genetic signatures of selection and seed trait loci in cultivated peanut Open
Introduction: Cultivated peanut (Arachis hypogaea L.) is an important oil crop for human nutrition and is cultivated in >100 countries. However, the present knowledge of its genomic diversity, evolution, and loci related to the seed traits…
View article: Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity Open
Background Lung adenocarcinoma (LUAD) is the most common diagnostic histologic subtype of non-small cell lung cancer, but the role of receptor-type tyrosine-protein phosphatase-like N (PTPRN) in LUAD has not been studied. Methods We conduc…
View article: The Major Intrinsic Protein Family and Their Function Under Salt-Stress in Peanut
The Major Intrinsic Protein Family and Their Function Under Salt-Stress in Peanut Open
Peanut ( Arachis hypogaea ) is an important oil crop cultivated across the world. Abiotic stresses are the major constraint factors that defect its yield, especially in the rainfed peanut cultivation areas. Aquaporins are proteins that for…
View article: A high swing charge pump with current mismatch reduction for PLL applications
A high swing charge pump with current mismatch reduction for PLL applications Open
A charge pump (CP) is widely used in modern phase-locked loop (PLL) implementations. The CP current mismatch is a dominant source of static phase offset and reference spur in the PLL output signals. In this paper, a novel CP with small cur…
View article: <i>TEAD4</i> is a novel independent predictor of prognosis in LGG patients with <i>IDH</i> mutation
<i>TEAD4</i> is a novel independent predictor of prognosis in LGG patients with <i>IDH</i> mutation Open
TEA domain family members (TEADs) play important roles in tumor progression. Till now, the genomic status of TEADs in patients with glioma has not been well investigated. To confirm whether the genomic status of TEADs could affect the prog…
View article: Insights into amphicarpy from the compact genome of the legume <i>Amphicarpaea edgeworthii</i>
Insights into amphicarpy from the compact genome of the legume <i>Amphicarpaea edgeworthii</i> Open
Amphicarpy (seed heteromorphy) is a unique and fascinating reproductive strategy wherein a single plant produces both aerial and subterranean fruits. This strategy is believed to be an adaptation to life under stressful or uncertain enviro…
View article: Factor Structure and Gender Invariance of Chinese Version State-Trait Anxiety Inventory (Form Y) in University Students
Factor Structure and Gender Invariance of Chinese Version State-Trait Anxiety Inventory (Form Y) in University Students Open
This study explored the factor structure and gender invariance of STAI-Y in Chinese university students. In sum, the four-factor structure of STAI-Y obtained the best goodness-of-fit and satisfied gender invariance which deepened the under…
View article: Tripterine Restrains the Aggressiveness of Hepatocellular Carcinoma Cell via Regulating miRNA-532-5p/CXCL2 Axis
Tripterine Restrains the Aggressiveness of Hepatocellular Carcinoma Cell via Regulating miRNA-532-5p/CXCL2 Axis Open
Zhi Tao Jiang,1,* Yi Han,1,* Xiao Yan Liu,1 Ling Yan Lv,1 Jin Huo Pan,2 Chun Di Liu1 1Department of Pharmacy Office, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, …
View article: 19.5 μW ultra‐low‐power 13.56 MHz RFID tag based on transparent zinc‐oxide thin‐film transistors
19.5 μW ultra‐low‐power 13.56 MHz RFID tag based on transparent zinc‐oxide thin‐film transistors Open
A novel systematic technological process for ZnO‐thin‐film transistors (TFTs) fabrication was developed which turned out to achieve near‐zero threshold voltage devices with good performance and stability. A deuterium implantation method wa…
View article: Early screening and risk factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients with Prader-Willi Syndrome
Early screening and risk factors of Autism Spectrum Disorder in a Large Cohort of Chinese Patients with Prader-Willi Syndrome Open
Raw scores of GARS-3 and ASQ-3 questionnaires, demographic, and other clinical features for the study on early screening and risk factors of Autism Spectrum Disorder in a large cohort of Chinese patients with Prader-Willi Syndrome.