Haoxuan Wu
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View article: H3k18la Regulates Ccr7 In Caf To Promote Oscc
H3k18la Regulates Ccr7 In Caf To Promote Oscc Open
Aim or purpose: The elevated lactate level in oral squamous cell carcinoma (OSCC) may affect the tumor microenvironment (TME) through lactylation, but the specific mechanism is still unknown. Our previous study has shown that CCR7 in the T…
View article: Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma
Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma Open
PURPOSE Systematic mediastinal lymph node dissection (LND) or sampling is currently recommended for patients with early-stage non–small cell lung cancer. We aimed to investigate whether no mediastinal LND was noninferior to systematic LND …
View article: Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein
Venetoclax synergizes with Wnt/β-catenin inhibitor C-82 in acute myeloid leukemia by increasing the degradation of Mcl-1 protein Open
Our findings propose an effective treatment strategy for AML patients through the combination of C-82 and VEN, positioning this regimen as a promising therapeutic option.
View article: Active surveillance for patients with multifocal ground-glass nodules: protocol of a prospective, multi-center, single-arm trial (ECTOP-1021)
Active surveillance for patients with multifocal ground-glass nodules: protocol of a prospective, multi-center, single-arm trial (ECTOP-1021) Open
This trial is officially registered on ClinicalTrials.gov (NCT06097910).
View article: Research on the shear behavior of PBL connectors in steel fiber reinforced concrete composite beam
Research on the shear behavior of PBL connectors in steel fiber reinforced concrete composite beam Open
View article: Study of the radiologic and pathologic correlations for subsolid lung adenocarcinoma with the application of whole-mount sections (ECTOP1011)
Study of the radiologic and pathologic correlations for subsolid lung adenocarcinoma with the application of whole-mount sections (ECTOP1011) Open
For subsolid lung cancers, the pathologic invasive size was radiologically underestimated. There were acinar/papillary, but no micropapillary subtype in pure GGO tumors. In part-solid tumors, there were micropapillary subtypes in GGO regio…
View article: Value of adjuvant chemotherapy for patients with <scp>pT2N0M0 non‐small</scp> cell lung cancer receiving radical resection
Value of adjuvant chemotherapy for patients with <span>pT2N0M0 non‐small</span> cell lung cancer receiving radical resection Open
Background Associations between adjuvant chemotherapy (ACT) and the improvement in survival for patients with pT2N0M0 non‐small cell lung cancer (NSCLC) who received R0 resection remain controversial. This study aimed to evaluate the value…
View article: Radiologic Identification of Pathologic Tumor Invasion in Patients With Lung Adenocarcinoma
Radiologic Identification of Pathologic Tumor Invasion in Patients With Lung Adenocarcinoma Open
Importance It is currently unclear whether high-resolution computed tomography can preoperatively identify pathologic tumor invasion for ground-glass opacity lung adenocarcinoma. Objectives To evaluate the diagnostic value of high-resoluti…
View article: Supplementary Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis
Supplementary Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Open
Roles of PRPS1 and PRPS1 in cell cycle progression and some of experimental verifications are included in this file.
View article: Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis
Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Open
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. PRPS1 participates in…
View article: Supplementary Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis
Supplementary Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Open
Roles of PRPS1 and PRPS1 in cell cycle progression and some of experimental verifications are included in this file.
View article: Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis
Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Open
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. PRPS1 participates in…
View article: Epidemiological landscape of esophageal cancer in Asia: Results from <scp>GLOBOCAN</scp> 2020
Epidemiological landscape of esophageal cancer in Asia: Results from <span>GLOBOCAN</span> 2020 Open
Background Esophageal cancer (EC) is a global health problem. Asia represents a huge burden of EC globally, and incidence and mortality vary considerably across different Asian regions. Methods Data on incidence, mortality, and preference …
View article: Selective Mediastinal Lymph Node Dissection Strategy for Clinical T1N0 Invasive Lung Cancer: A Prospective, Multicenter, Clinical Trial
Selective Mediastinal Lymph Node Dissection Strategy for Clinical T1N0 Invasive Lung Cancer: A Prospective, Multicenter, Clinical Trial Open
This is the first prospective trial validating the specific mediastinal LN metastasis pattern in cT1N0 invasive NSCLC, which provides important evidence for clinical applications of selective LN dissection strategy.
View article: Syndrome decoding meets multiple instances
Syndrome decoding meets multiple instances Open
The NP-hard problem of decoding random linear codes is crucial to both coding theory and cryptography. In particular, this problem underpins the security of many code based post-quantum cryptographic schemes. The state-of-art algorithms fo…
View article: Research on Bridge Damage Identification Based on WPE-MDS and HTF-SAPSO
Research on Bridge Damage Identification Based on WPE-MDS and HTF-SAPSO Open
In recent decades, structural damage identification based on the wavelet analysis method has been widely developed, but it is still confronted with many difficulties, such as large decomposition error and complex data. In order to overcome…
View article: Interpretable Latent Variables in Deep State Space Models
Interpretable Latent Variables in Deep State Space Models Open
We introduce a new version of deep state-space models (DSSMs) that combines a recurrent neural network with a state-space framework to forecast time series data. The model estimates the observed series as functions of latent variables that…
View article: Drift vs Shift: Decoupling Trends and Changepoint Analysis
Drift vs Shift: Decoupling Trends and Changepoint Analysis Open
We introduce a new approach for decoupling trends (drift) and changepoints (shifts) in time series. Our locally adaptive model-based approach for robustly decoupling combines Bayesian trend filtering and machine learning based regularizati…
View article: Prognostic implication of tumor spread through air spaces in patients with pathologic N0 lung adenocarcinoma
Prognostic implication of tumor spread through air spaces in patients with pathologic N0 lung adenocarcinoma Open
In this study, STAS was an independent prognostic factor for RFS in pathologic N0 lung adenocarcinomas, and it was also an independent prognostic factor for RFS and OS in patients with APA/PPA/IMA and those who received lobectomy.
View article: The Prognostic Value of Preoperative Serum Tumor Markers in Non-Small Cell Lung Cancer Varies With Radiological Features and Histological Types
The Prognostic Value of Preoperative Serum Tumor Markers in Non-Small Cell Lung Cancer Varies With Radiological Features and Histological Types Open
Objectives To assess the association between common-used serum tumor markers and recurrence of lung adenocarcinoma and squamous cell carcinoma separately and determine the prognostic value of serum tumor markers in lung adenocarcinoma feat…
View article: Ground glass opacity featured lung adenocarcinoma in teenagers
Ground glass opacity featured lung adenocarcinoma in teenagers Open
View article: Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? —a prospective multi-center cohort study
Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? —a prospective multi-center cohort study Open
FB examination was unnecessary in the preoperative assessment of peripheral clinical T1N0 subsolid lung cancer.
View article: Postoperative Chemotherapy after Pneumonectomy in PIIB-PIIIB Non-Small-Cell Lung Cancer: A Safe Treatment but Lack of Survival Benefits
Postoperative Chemotherapy after Pneumonectomy in PIIB-PIIIB Non-Small-Cell Lung Cancer: A Safe Treatment but Lack of Survival Benefits Open
Background. Few reports have focused on postoperative chemotherapy (POCT) in stage pIIB-pIIIB non-small-cell lung cancer (NSCLC) patients after pneumonectomy. The safety and survival benefits of POCT have not been thoroughly evaluated amon…
View article: Intrinsic soil property effects on Cd phytotoxicity to Ligustrum japonicum ‘Howardii’ expressed as different fractions of Cd in forest soils
Intrinsic soil property effects on Cd phytotoxicity to Ligustrum japonicum ‘Howardii’ expressed as different fractions of Cd in forest soils Open
A better comprehensive understanding of the influence of soil/solution properties on cadmium (Cd) phytotoxicity is essential for soil Cd ecological risk assessment. The toxicity of soil spiked Cd to Ligustrum japonicum 'Howardii' seedling …
View article: Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis
Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis Open
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. PRPS1 participates in…
View article: ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet‐derived growth factor BB
ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet‐derived growth factor BB Open
ETS transcription factors play important roles in tumor cell invasion, differentiation and angiogenesis. In this study, we initially demonstrated that ETS translocation variant 5 (ETV5) is abnormally upregulated in colorectal cancer (CRC),…
View article: Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors:<i> A Systematic Review and Meta-Analysis</i>
Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors:<i> A Systematic Review and Meta-Analysis</i> Open
Purpose . Nonsurgical therapies, including biotherapy, chemotherapy, and liver-directed therapy, provided a limit survival benefit for PNET patients with hepatic metastases. With the development of liver resection technique, there was a co…
View article: Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer
Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer Open
Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma and some other solid tumors. However, the direct functional mechanisms of tumor lethality medi…
View article: LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer
LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer Open
Leukemia inhibitory factor receptor (LIFR) has been documented as a cancer promoter and to be present at high levels in various types of tumor tissues. In our search for molecules prognostic of colorectal cancer (CRC), we found high levels…
View article: Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway
Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway Open
Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation i…