Hongsheng Xie
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View article: The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy
The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy Open
Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patient needs drive ongoing innovation in ADC development. E…
View article: Gray matter structural alterations in first-episode drug-naïve adolescents with major depressive disorder: a comprehensive morphological analysis study
Gray matter structural alterations in first-episode drug-naïve adolescents with major depressive disorder: a comprehensive morphological analysis study Open
Background Major depressive disorder (MDD) tends to emerge during adolescence; however, neurobiological research in adolescents has lagged behind that in adults. This study aimed to characterize gray matter (GM) structural alterations in a…
View article: Disorganized thalamic subregional functional connectivity in bipolar I disorder
Disorganized thalamic subregional functional connectivity in bipolar I disorder Open
Thalamus plays a pivotal role in the pathophysiology of neuropsychiatric conditions due to its strategic position and intricate connectivity with the cerebral cortex, limbic system, and other subcortical structures. In the present study, t…
View article: Brain Abnormalities in Long COVID-19 Patients: Comparative Neuroimaging Findings in Adults and Children
Brain Abnormalities in Long COVID-19 Patients: Comparative Neuroimaging Findings in Adults and Children Open
View article: The image quality, amyloid-β detectability, and acquisition time of clinical florbetapir positron emission tomography in Alzheimer’s disease and healthy adults
The image quality, amyloid-β detectability, and acquisition time of clinical florbetapir positron emission tomography in Alzheimer’s disease and healthy adults Open
The acquisition time of AV45 PET is required to reach at least 6 minutes to achieve acceptable image quality and maintained Aβ detectability.
View article: Brain‐derived subgroups of bipolar <scp>II</scp> depression associate with inflammation and choroid plexus morphology
Brain‐derived subgroups of bipolar <span>II</span> depression associate with inflammation and choroid plexus morphology Open
Aim Elevated inflammation and larger choroid plexus (ChP) volume has been previously identified in mood disorders. Connections between inflammation, ChP, and clinical symptoms in bipolar II depression (BDII‐D) are unclear. Data‐driven clus…
View article: Brain default mode network mediates the association between negative perfectionism and exercise dependence
Brain default mode network mediates the association between negative perfectionism and exercise dependence Open
Background and aims Perfectionism is correlated with the occurrence of exercise dependence. We aim to reveal the role of functional connectivity (FC) between gray matter (GM) and white matter (WM) networks in the association between perfec…
View article: Molecular imaging biomarkers in familial frontotemporal lobar degeneration: Progress and prospects
Molecular imaging biomarkers in familial frontotemporal lobar degeneration: Progress and prospects Open
Familial frontotemporal lobar degeneration (FTLD) is a pathologically heterogeneous group of neurodegenerative diseases with diverse genotypes and clinical phenotypes. Three major mutations were reported in patients with familial FTLD, nam…
View article: Altered brain activation during reward anticipation in bipolar disorder
Altered brain activation during reward anticipation in bipolar disorder Open
View article: Role of lipoic acid in multiple sclerosis
Role of lipoic acid in multiple sclerosis Open
Lipoic acid (LA) is an endogenous antioxidant that exists widely in nature. Supplementation with LA is a promising approach to improve the outcomes of patients with multiple sclerosis (MS). This systematic review aimed to provide a compreh…
View article: Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy
Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy Open
Fabry disease is a lysosomal storage disorder caused by the deficiency of α-galactosidase A. Enzyme deficiency results in a progressive decline in renal and cardiac function, leading to cardiomyopathy and end-stage renal disease. Current t…
View article: Pharmacokinetics and Bioavailability of a Therapeutic Enzyme (Idursulfase) in Cynomolgus Monkeys after Intrathecal and Intravenous Administration
Pharmacokinetics and Bioavailability of a Therapeutic Enzyme (Idursulfase) in Cynomolgus Monkeys after Intrathecal and Intravenous Administration Open
Intravenous enzyme replacement therapy with iduronate-2-sulfatase is an approved treatment for Hunter syndrome, however, conventional intravenous delivery cannot treat the neurologic manifestations of the disease due to its limited central…