Li Liu
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View article: Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia
Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia Open
This study comprehensively investigates the role of glycolysis in acute myeloid leukemia (AML) pathogenesis. Elevated glycolysis correlated significantly with poor prognosis. Bioinformatics identified HIF1A and MIF as key regulators and re…
View article: Association Between Insulin Therapy and In‐Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume
Association Between Insulin Therapy and In‐Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume Open
Aims To examine the association of insulin therapy with in‐hospital death and whether this association is mediated by elevated plasma volume among chronic heart failure (CHF) patients with type 2 diabetes mellitus (T2DM). Materials and Met…
View article: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: a systematic review of the past decade (2014–2023)
Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: a systematic review of the past decade (2014–2023) Open
View article: Simulation design of a reconfigurable microwave photonic channelized receiver based on a coupled-resonator optical waveguide filter array
Simulation design of a reconfigurable microwave photonic channelized receiver based on a coupled-resonator optical waveguide filter array Open
To meet the growing demand for high-frequency broadband signal processing in complex electromagnetic environments and to overcome the limitations of conventional electronic systems—such as restricted bandwidth, limited response speed, and …
View article: A Hybrid L1–L2 Twin Support Vector Regression Model with Local Strategy for Basic Oxygen Furnace Steel‐Making Endpoint Prediction
A Hybrid L1–L2 Twin Support Vector Regression Model with Local Strategy for Basic Oxygen Furnace Steel‐Making Endpoint Prediction Open
The accurate prediction of the endpoint carbon temperature in basic oxygen furnace (BOF) steel‐making is the key to determining the final stage of steel‐making. In this work, a machine learning model for endpoint carbon content and tempera…
View article: Featured Cover
Featured Cover Open
The cover image is based on the article Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells by Changsen Bai et al., https://doi.org/10.1111/cpr.70…
View article: Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index
Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index Open
Gastrointestinal (GI) tumours account for a significant proportion of cancer cases and deaths globally; GI tumours show similarities regarding their development, diagnosis and treatment. Genomic and transcriptome analyses have been used to…
View article: Protein isolates derived from pea seeds pre-treated with radio frequency: Changes in global proteomes and impacts on nutritional and functional properties
Protein isolates derived from pea seeds pre-treated with radio frequency: Changes in global proteomes and impacts on nutritional and functional properties Open
View article: Impact of vaccination on SARS-CoV-2 infections and long COVID symptoms: a cross-sectional study in China
Impact of vaccination on SARS-CoV-2 infections and long COVID symptoms: a cross-sectional study in China Open
View article: NorMuon: Making Muon more efficient and scalable
NorMuon: Making Muon more efficient and scalable Open
The choice of optimizer significantly impacts the training efficiency and computational costs of large language models (LLMs). Recently, the Muon optimizer has demonstrated promising results by orthogonalizing parameter updates, improving …
View article: AI-Based System for Analysis of Electron Microscope Images in Glomerular Disease
AI-Based System for Analysis of Electron Microscope Images in Glomerular Disease Open
Importance Kidney biopsy pathology via transmission electron microscopy (TEM) is essential for diagnosing glomerular diseases, offering critical information on glomerular basement membrane (GBM) thickness, foot process (FP) number, and ele…
View article: Immune subtyping of lymph node metastasis-negative colorectal cancer reveals biomarkers for prognosis and immunotherapy response
Immune subtyping of lymph node metastasis-negative colorectal cancer reveals biomarkers for prognosis and immunotherapy response Open
Background Lymph node metastasis (LNM) is a key prognostic factor in colorectal cancer (CRC), and early lymph node status assessment is crucial for prognosis and immunotherapy decisions. However, the immune characteristics of LNM-negative …
View article: Projection from the parafascicular nucleus of the thalamus to the insular cortex mediate analgesia and anti-anxiety behaviors in mice
Projection from the parafascicular nucleus of the thalamus to the insular cortex mediate analgesia and anti-anxiety behaviors in mice Open
View article: Protective roles of melatonin regulated mitochondrial DNA methylation and respiratory metabolism in ram sperm cryopreservation
Protective roles of melatonin regulated mitochondrial DNA methylation and respiratory metabolism in ram sperm cryopreservation Open
Mitochondrial dysfunction, especially compromised respiratory metabolism, is a serious obstacle of sperm cryopreservation. This study aims to determine the effect of melatonin supplement on respiratory metabolism of frozen-thawed ram sperm…
View article: A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer
A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer Open
Introduction Colorectal Cancer (CRC) remains a leading cause of cancer-related mortality, characterized by substantial interpatient heterogeneity and limited effective prognostic biomarkers. Methods To address this gap, we constructed a ro…
View article: Tackling Uncertainty in Reinforcement Learning: A Dual Variational Inference Approach for Task and State Estimation
Tackling Uncertainty in Reinforcement Learning: A Dual Variational Inference Approach for Task and State Estimation Open
Uncertainty in decision-making processes presents a critical challenge for autonomous agents, often leading to suboptimal or erroneous policies. This paper addresses two prevalent yet distinct types of uncertainty that significantly degrad…
View article: Diversity Characteristics and Composition of Gut Microbiota in Antheraea pernyi (Lepidoptera: Saturniidae) Larvae Across Different Instars
Diversity Characteristics and Composition of Gut Microbiota in Antheraea pernyi (Lepidoptera: Saturniidae) Larvae Across Different Instars Open
Antheraea pernyi (Lepidoptera: Saturniidae) is an economically important silk-producing insect, whose gut microbiota play a crucial role in growth, development, and nutrient metabolism. This study focused on the entire larval developmental…
View article: The association between reported artificial light and reported physical activity at night: the mediating roles of environmental restorativeness and perceived safety
The association between reported artificial light and reported physical activity at night: the mediating roles of environmental restorativeness and perceived safety Open
Artificial light at night may facilitate physical activity after sunset. To investigate this possibility, we conducted a survey with 646 Chinese adults to examine the associations between both subjectively and objectively measured artifici…
View article: Effect of Lactiplantibacillus plantarum LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler
Effect of Lactiplantibacillus plantarum LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler Open
Introduction The purpose of this study was to investigate the effects of dietary supplementation of Lactiplantibacillus plantarum LPJZ-658 on body weight and serum indexes of Luhua broiler, and to explore the relevant mechanism of probioti…
View article: Exploiting Convexity of Neural Networks in Dynamic Operating Envelope Optimization for Distributed Energy Resources
Exploiting Convexity of Neural Networks in Dynamic Operating Envelope Optimization for Distributed Energy Resources Open
The increasing penetration of distributed energy resources (DERs) brings opportunities and challenges to the operation of distribution systems. To ensure network integrity, dynamic operating envelopes (DOEs) are issued by utilities to DERs…
View article: SMN-AgroCLA: Comparison of Different Normalization Methods for Improving Rice Yield Prediction Accuracy Using Remote Sensing Data in Eastern China from 2008 to 2017
SMN-AgroCLA: Comparison of Different Normalization Methods for Improving Rice Yield Prediction Accuracy Using Remote Sensing Data in Eastern China from 2008 to 2017 Open
Yield prediction is crucial for national food security and the formulation of trade policies. Most deep learning (DL) models rely on normalization methods to process input data, aiming to enhance the stability of model training and acceler…
View article: Elevated C-reactive protein and D-dimer to predict venous thromboembolism in patients with bladder cancer
Elevated C-reactive protein and D-dimer to predict venous thromboembolism in patients with bladder cancer Open
Objective This study evaluated C-reactive protein (CRP) in hospitalized patients with bladder cancer (BC) and explored the predictive value of CRP for venous thromboembolism (VTE), combining CRP and D-dimer (D-D) levels to improve the abil…
View article: Telecoupling China's rice production: features and causes
Telecoupling China's rice production: features and causes Open
View article: A multi-layered systems biology framework reveals dual-phased regulators and hormonal crosstalk underlying soybean cold tolerance
A multi-layered systems biology framework reveals dual-phased regulators and hormonal crosstalk underlying soybean cold tolerance Open
Cold stress poses a significant threat to soybean ( Glycine max (L.) Merr) productivity, particularly during early developmental stages. Traditional approaches for identifying cold-responsive genes have been limited by gene size bias, path…
View article: 0776 Environmental polycyclic aromatic hydrocarbons augment UVB systemic immunosuppressive effects via platelet-activating factor and microvesicles
0776 Environmental polycyclic aromatic hydrocarbons augment UVB systemic immunosuppressive effects via platelet-activating factor and microvesicles Open
View article: Tighter Bounds for Personalized PageRank
Tighter Bounds for Personalized PageRank Open
We study Personalized PageRank (PPR), where for nodes $s,t$ in a graph $G$, $π(s,t)$ is the probability that an $α$-decay random walk from $s$ ends at $t$. Two key queries are: Single-Source PPR (SSPPR), computing $π(s,\cdot)$ for fixed $s…
View article: DistFlow: A Fully Distributed RL Framework for Scalable and Efficient LLM Post-Training
DistFlow: A Fully Distributed RL Framework for Scalable and Efficient LLM Post-Training Open
Reinforcement learning (RL) has become the pivotal post-training technique for large language model (LLM). Effectively scaling reinforcement learning is now the key to unlocking advanced reasoning capabilities and ensuring safe, goal-align…
View article: Adding Ethanol to the Batch and Continuous Transplantation Co-Culture of Maize Straw Fermented by Rumen Fluid for the Production of Caproic Acid
Adding Ethanol to the Batch and Continuous Transplantation Co-Culture of Maize Straw Fermented by Rumen Fluid for the Production of Caproic Acid Open
In this study, to enhance the concentration of caproic acid generated from maize straw fermentation and clarify the structures of bacterial and fungal communities within the serially subcultured rumen microbial fermentation system, maize s…
View article: De novo designed protein guiding targeted protein degradation
De novo designed protein guiding targeted protein degradation Open
View article: Target of Rapamycin (TOR) signaling coordinates a balance between wheat photosynthetic performance and transpirational water conservation for improved water use efficiency and performance under drought
Target of Rapamycin (TOR) signaling coordinates a balance between wheat photosynthetic performance and transpirational water conservation for improved water use efficiency and performance under drought Open