Hara Prasad Mishra
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View article: Curcuma Longa Phytocompounds: An in Silico Analysis Aimed at Targeting the EGFR Protein as a Potential Anti-cancer Agent
Curcuma Longa Phytocompounds: An in Silico Analysis Aimed at Targeting the EGFR Protein as a Potential Anti-cancer Agent Open
>Background: Curcumin, a well-known phytocompound in turmeric, has demonstrated anti-cancer properties. However, its therapeutic efficacy is often limited. Additionally, Epidermal Growth Factor Receptor (EGFR) is frequently overexpressed i…
View article: Understanding the Association Between Obesity and Obstructive Sleep Apnea Syndrome: A Case-Control Study
Understanding the Association Between Obesity and Obstructive Sleep Apnea Syndrome: A Case-Control Study Open
Introduction Obstructive sleep apnea (OSA) represents a sleep-related impairment linked to upper airway function. The question of whether OSA drives obesity or if shared underlying factors contribute to both conditions remains unresolved. …
View article: Oxidative Stress in Wistar Rats Under Acute Restraint Stress and Its Modulation by Antioxidants and Nitric Oxide Modulators
Oxidative Stress in Wistar Rats Under Acute Restraint Stress and Its Modulation by Antioxidants and Nitric Oxide Modulators Open
Our study findings highlight the complex role of antioxidants and NO modulators in the pathogenesis of diseases, as evidenced by the reversal of oxidative stress indicators. Antioxidant therapy, with its potential to mitigate oxidative str…
View article: Assessment of Leptin Levels and Their Correlation With the Severity of Obstructive Sleep Apnea Syndrome: A Case-Control Study
Assessment of Leptin Levels and Their Correlation With the Severity of Obstructive Sleep Apnea Syndrome: A Case-Control Study Open
Background Obstructive sleep apnea (OSA) is characterized by a combination of structural issues in the upper airway and imbalances in the respiratory control system. While numerous studies have linked OSA with obesity, it remains uncertain…
View article: The Surrogacy Regulation Act of 2021: A Right Step Towards an Egalitarian and Inclusive Society?
The Surrogacy Regulation Act of 2021: A Right Step Towards an Egalitarian and Inclusive Society? Open
With the advent of major scientific and technological advancements in obstetrics and gynecology, surrogacy is quickly becoming a viable alternative to enable people of all genders to become parents. However, its path toward reality is stil…
View article: Piperlongumine prospective COX-2 inhibitors were screened virtually using molecular docking, molecular dynamics simulations, and free energy calculations
Piperlongumine prospective COX-2 inhibitors were screened virtually using molecular docking, molecular dynamics simulations, and free energy calculations Open
Acquired drug resistance is one of the key clinical problems and the main downsides of chemotherapy regimens for colorectal cancer. Using blend regimens, which mix conventional chemotherapeutic medications through plant-derived natural com…
View article: Future Prospects of Insulin Mutants, Biosimilars, Bioconjugates, and Newer Insulin-Delivery Devices in Diabetes Mellitus
Future Prospects of Insulin Mutants, Biosimilars, Bioconjugates, and Newer Insulin-Delivery Devices in Diabetes Mellitus Open
Insulin is the cornerstone of type 1 diabetes therapy and a critical addition for type 2 diabetes control. Despite significant advancements in insulin therapy research, including the creation of innovative insulin formulations and delivery…
View article: Drug development hit by war
Drug development hit by war Open
View article: Genomic Surveillance of COVID-19 Variants With Language Models and Machine Learning
Genomic Surveillance of COVID-19 Variants With Language Models and Machine Learning Open
The global efforts to control COVID-19 are threatened by the rapid emergence of novel SARS-CoV-2 variants that may display undesirable characteristics such as immune escape, increased transmissibility or pathogenicity. Early prediction for…
View article: "Eradication of Viral Diseases, A Time to Rethink During the Covid Pandemic; Focusing on Smallpox "
"Eradication of Viral Diseases, A Time to Rethink During the Covid Pandemic; Focusing on Smallpox " Open
Eradication of viral pathogens is an arduous task. We have all seen how Covid-19 forced the entire world into a standstill during these preceding two years. Not much success has been achieved in the past to eradicate such pathogens. The mi…
View article: Evaluation of Developmental and Reproductive Fitness of Laboratory Selected Thiamethoxam Resistance in Black Legume Aphid Aphis craccivora Koch.
Evaluation of Developmental and Reproductive Fitness of Laboratory Selected Thiamethoxam Resistance in Black Legume Aphid Aphis craccivora Koch. Open
Thiamethoxam is a neonicotinoid group of insecticide which are selective agonists of the insect nicotinic acetylcholine receptor (nAChR), a pentameric cys-loop ligand-gated ion channel located in the central nervous system of insects. They…