Harald Unterweger
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View article: Destructive Testing of the Pinkabach Railway Bridge – Large scale Testing of Sensor Systems for Fatigue Crack Monitoring and System Identification
Destructive Testing of the Pinkabach Railway Bridge – Large scale Testing of Sensor Systems for Fatigue Crack Monitoring and System Identification Open
The work presents experiments carried out on an out-of-service steel railway bridge, the so called Pinkabach bridge. The objective was to test advanced and novel sensor systems, i.e. Distributed Fiber Optic Sensing (DFOS) and Acoustic Emis…
View article: Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features
Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features Open
Older atherosclerotic plaques with vulnerable features in rabbits are a useful tool for investigating iron oxide-based contrast agents for MRI. Based on the experimental data, SPIONDex particles constitute a promising candidate for further…
View article: Impact of coating type on structure and magnetic properties of biocompatible iron oxide nanoparticles: insights into cluster organization and oxidation stability
Impact of coating type on structure and magnetic properties of biocompatible iron oxide nanoparticles: insights into cluster organization and oxidation stability Open
This research investigates the impact of various coatings on superparamagnetic iron oxide nanoparticles. The coatings stabilize the nanoparticles, influencing their magnetic behaviour, agglomeration, and oxidation stability.
View article: Insights into the occurrence of transverse bending stresses in web plates of crane runway girders
Insights into the occurrence of transverse bending stresses in web plates of crane runway girders Open
Crane runway girders are installed in industrial buildings to carry heavy loads from crane operation. The wheels of the bridge crane introduce concentrated forces in the crane runway girder via the rails. This leads to local vertical stres…
View article: Load capacity of penstock manifolds subjected to increasing settlements at the vertical supports
Load capacity of penstock manifolds subjected to increasing settlements at the vertical supports Open
Hydroelectric power plants usually have penstock manifolds near the powerhouse, including individual bifurcations to provide several turbines. These steel constructions have numerous vertical supports and are designed based on linear elast…
View article: Specific distortion‐induced fatigue failure at main girders of a railway bridge – efficiency of different reinforcements based on strain measurements
Specific distortion‐induced fatigue failure at main girders of a railway bridge – efficiency of different reinforcements based on strain measurements Open
At the main girders of a three span continuous girder railway bridge, built in the 1960s, through‐thickness cracks were detected in the web, at the location of the transverse stiffener to main girder connections. The transverse stiffeners …
View article: Fatigue behavior at flange thickness transitions with cope holes – design model for engineering practice
Fatigue behavior at flange thickness transitions with cope holes – design model for engineering practice Open
Flange thickness transitions are common constructional details in welded girders, such as crane runway girders or main girders of highway and railway bridges, to adapt the bending moment capacity of the girder to variable bending moment di…
View article: Different fatigue design stress methods for common constructional details in cylindrical shells under axial loading – Influence of the r/t‐ratio and the shell thickness
Different fatigue design stress methods for common constructional details in cylindrical shells under axial loading – Influence of the r/t‐ratio and the shell thickness Open
Cylindrical shells are frequently used in industrial constructions, for example in pipes, towers and masts and are often subjected to fatigue loading. Two common welded constructional details were studied: i) detail 1, the wall thickness t…
View article: Stress increases in crane runway girders due to rail joints
Stress increases in crane runway girders due to rail joints Open
Vertically acting wheel loads from overhead bridge cranes and potential additional horizontal crane loads induce two types of stresses in crane runway girders: i) global stresses due to bi‐axial bending and torsion and ii) local stresses w…
View article: Fatigue behavior of girder with flange thickness transitions and cope holes ‐ tests and simulations
Fatigue behavior of girder with flange thickness transitions and cope holes ‐ tests and simulations Open
The fatigue behavior of steel girders with flange thickness transition and cope hole has been experimentally analyzed with two large‐scale cyclic tests. Special attention is paid to the arising and interacting local effects. The fatigue te…
View article: Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality
Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality Open
Background Immunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer of tumor-specific T cells represents an effective treatment option for tumors of the hematological system…
View article: Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway
Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway Open
Nanoparticle-based therapeutics are being clinically translated for treating cancer. Even when thought to be biocompatible, nanoparticles are being increasingly identified as altering cell regulation and homeostasis. Antioxidant pathways a…
View article: Impact of rail joints on the local stresses in crane runway girders
Impact of rail joints on the local stresses in crane runway girders Open
Vertically acting wheel loads from overhead bridge cranes and potential additional horizontal crane loads induce global stresses due to bi-axial bending and torsion and local stresses in crane runway girders which mainly affect the girder’…
View article: Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety
Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety Open
The results indicate that SPIONDex possess an exceptional safety compared to the other two formulations, making them a promising candidate for further clinical translation.
View article: Experimental Research in Synthetic Molecular Communications -- Part I: Overview and Short-Range Systems
Experimental Research in Synthetic Molecular Communications -- Part I: Overview and Short-Range Systems Open
Since its emergence from the communication engineering community around one and a half decades ago, the field of Synthetic Molecular Communication (SMC) has experienced continued growth, both in the number of technical contributions from a…
View article: Experimental Research in Synthetic Molecular Communications -- Part II: Long-Range Communication
Experimental Research in Synthetic Molecular Communications -- Part II: Long-Range Communication Open
In this second part of our survey on experimental research in Synthetic Molecular Communication (SMC), we review works on long-range SMC systems, i.e., systems with communication ranges of more than a few millimeters. Despite the importanc…
View article: Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy
Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy Open
We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution …
View article: Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes
Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes Open
Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of various sizes can be used as contrast agents in magnetic resonance imaging (MRI) of different tissues, e.g., liver or atherosclerotic plaques, after intravenous inject…
View article: Reduction of the in vitro toxicity of elevated concentrations of SPIONLA by its administration through PHBV/curcumin composite microspheres
Reduction of the in vitro toxicity of elevated concentrations of SPIONLA by its administration through PHBV/curcumin composite microspheres Open
Superparamagnetic iron oxide nanoparticles have been developed for various biomedical applications for decades. In this work, lauric acid-coated SPION (SPION LA ) were incorporated into poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) …
View article: Orally Administered Nanoparticles for Gastrointestinal Applications
Orally Administered Nanoparticles for Gastrointestinal Applications Open
NanomedicineAhead of Print Journal WatchOrally administered nanoparticles for gastrointestinal applicationsRainer Tietze, Harald Unterweger, Christina Janko, Mehtap Civelek, Iwona Cicha, Helmut Spielvogel & Christoph AlexiouRainer TietzeDe…
View article: Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent
Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent Open
Nanoformulations for delivering nucleotides into cells as vaccinations as well as treatment of various diseases have recently gained great attention. Applying such formulations for a local treatment strategy, e.g., for cancer therapy, is s…
View article: Calibrated design model for the compression capacity of angle members – Consideration of welded or bolted joint configurations
Calibrated design model for the compression capacity of angle members – Consideration of welded or bolted joint configurations Open
Due to the commonly eccentric connection on only one angle leg (bolted or welded), additional bending moments are acting on the angle member under compression axial force, leading to a complex load‐carrying behaviour with flexural and/or f…
View article: Distortion – Induced Fatigue Failure at Main Girders of a Railway Bridge – Strain Measurements in Service and Analyses Based on Fracture Mechanics
Distortion – Induced Fatigue Failure at Main Girders of a Railway Bridge – Strain Measurements in Service and Analyses Based on Fracture Mechanics Open
At the main girders of a three span continuous plate girder railway bridge, built in the 1970s, through‐thickness cracks were detected in the web, at the location of the transverse stiffener to main girder connections. Based on former Aust…
View article: Calibrated Design Model for the Compression Capacity of Angle Members with Welded Joints Including Accurate Joint Stiffness
Calibrated Design Model for the Compression Capacity of Angle Members with Welded Joints Including Accurate Joint Stiffness Open
Due to the commonly eccentric connection on only one angle leg (bolted or welded), additional bending moments are acting on the member, leading to a complex load carrying behavior with flexural and/or lateral torsional buckling phenomena. …
View article: Effect of Hyperthermia and Cellular SPION Uptake on Various Head and Neck Cancer Cell Lines
Effect of Hyperthermia and Cellular SPION Uptake on Various Head and Neck Cancer Cell Lines Open
Introduction Cisplatin is one of the standard treatments of head and neck tumors leading frequently to severe systemic side effects. This could be improved by targeted drug delivery with nanoparticles in combination with local hyperthermia…
View article: IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes
IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes Open
Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. N…
View article: 29 SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications
29 SPIONs and magnetic hybrid materials: Synthesis, toxicology and biomedical applications Open
In the past decades, a wide variety of different superparamagnetic iron oxide nanoparticles (SPIONs) have been synthesized. Due to their unique properties, such as big surface-to-volume ratio, superparamagnetism and comparatively low toxic…
View article: Effects of warping torsion on the buckling behaviour of slender box sections
Effects of warping torsion on the buckling behaviour of slender box sections Open
Welded steel box sections are applied in various fields like in bridges as well as in structural engineering and industrial constructions. Apart from square‐shaped sections, these sections have the tendency to warp under torsion. Therefore…