Hari K. Akula
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Deuterium- and Fluorine-18-Labeled Glutamine─a PET Imaging Agent with Enhanced In Vivo Stability Open
Deuterium and fluorine-18 dual-isotope-labeled fluoroglutamine, (2S,4R)-[4-18F-3,3,4-d 3]-fluoroglutamine (4-[18F]-FGln-d 3), was designed, synthesized, and biologically evaluated for its potential as a novel glutamine metabolic imaging ag…
View article: Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[<sup>18</sup>F]F-<i>p</i>-Aminobenzoic Acid ([<sup>18</sup>F]F-PABA)
Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[<sup>18</sup>F]F-<i>p</i>-Aminobenzoic Acid ([<sup>18</sup>F]F-PABA) Open
Deep-seated bacterial infections are difficult to detect and diagnose due to the lack of specific clinical imaging modalities. Therefore, the bacteria-specific positron emission tomography radiotracer 2-[18F]fluoro-4-nitrobenzoic acid ([18…
The potential utility of (2S,4R)-4-[18F]fluoroglutamine as a novel metabolic imaging marker for inflammation explored by rat models of arthritis and paw edema Open
Purpose (2S,4R)-4-[18F]fluoroglutamine ([18F]FGln) is a promising metabolic imaging marker in cancer. Based on the fact that major inflammatory cells are heavily dependent on glutamine metabolism like cancer cells, we explored the potentia…
View article: Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled <scp>l</scp>-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection
Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled <span>l</span>-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection Open
To fully explore the potential of 18F-labeled l-fluoroalanine for imaging cancer and other chronic diseases, a simple and mild radiosynthesis method has been established to produce optically pure l-3-[18F]fluoroalanine (l-[18F]FAla), using…
An improved synthesis of [<sup>18</sup>F]VAT and its precursor Open
The vesicular acetylcholine transporter (VAChT) in the brain is an important presynaptic cholinergic biomarker, and neuroimaging studies of VAChT may provide in vivo information about psychiatric and neurologic conditions including Alzheim…
View article: Cover Picture: Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine (Adv. Synth. Catal. 1/2020)
Cover Picture: Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine (Adv. Synth. Catal. 1/2020) Open
The inside cover picture, designed by Lakshman and co-workers, illustrates a diverse set of hydrogenations that can be conducted without use of external hydrogen gas (compressed gas). 4-Methylmorpholine (NMM), tetrahydroxydiboron [B2(OH)4]…
View article: Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine
Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine Open
Facile reduction of aryl halides with a combination of 5% Pd/C, B 2 (OH) 4 , and 4‐methylmorpholine is reported. Aryl bromides, iodides, and chlorides were efficiently reduced. Aryl dihalides containing two different halogen atoms underwen…
View article: Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products Open
Correction for ‘Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products…
View article: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products Open
Amide group activation with BOP leads to facile modification at the C4 position of pyrimidine nucleosides.
View article: Ruthenium-Catalyzed C–H Bond Activation Approach to Azolyl Aminals and Hemiaminal Ethers, Mechanistic Evaluations, and Isomer Interconversion
Ruthenium-Catalyzed C–H Bond Activation Approach to Azolyl Aminals and Hemiaminal Ethers, Mechanistic Evaluations, and Isomer Interconversion Open
C(sp3)-N bond-forming reactions between benzotriazole and 5,6-dimethylbenzotriazole with N-methylpyrrolidinone, tetrahydrofuran, tetrahydropyran, diethyl ether, 1,4-dioxane, and isochroman have been conducted using RuCl3•3H2O/t-BuOOH in 1,…