Explanipedia

Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury Open

Michael R. Mathis, Graciela Mentz, Jie Cao, Emily A. Balczewski, Allison M. Janda , et al. · 2025

Importance Approximately 30% of US patients develop acute kidney injury (AKI) after cardiac surgery, which is associated with increased morbidity, mortality, and health care costs. The variation in potentially modifiable hospital- and clin…

Multicenter evaluation of left ventricular assist device implantation with or without <span>ECMO</span> bridge in cardiogenic shock Open

James W. Schurr, Lara Ambrosi, Jillian Fitzgerald, C. Bermúdez, Michael V. Genuardi , et al. · 2024

Background The efficacy of extracorporeal membrane oxygenation (ECMO) as a bridge to left ventricular assist device (LVAD) remains unclear, and recipients of the more contemporary HeartMate 3 (HM3) LVAD are not well represented in previous…

Deciphering cell states and genealogies of human haematopoiesis Open

Chen Weng, Fulong Yu, Dian Yang, Michael Poeschla, L. Alexander Liggett , et al. · 2024

The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs) 1 . Perturbations to this process underlie diverse diseases, but the clonal contr…

Erratum to IL-33 mediates Pseudomonas induced airway fibrogenesis and is associated with CLAD Open

Mudassir M. Banday, Sangeetha B. Rao, Shruthi Shankar, Mudasir A. Khanday, Jon Finan , et al. · 2023

2714. Invasive Fungal Disease in Lung Transplant Recipients: Incidence, Risk Factors, and Outcomes Open

Victor Kovac, Hilary J. Goldberg, Andy Kim, Mary-Ruth M Joyce, Hari R. Mallidi , et al. · 2023

Background Invasive fungal disease (IFD) is common after lung transplant and is associated with increased morbidity and mortality. Antifungal prophylaxis is a common preventative strategy against IFD in lung transplant recipients (LTRs). W…

Bridging strategies and cardiac replacement outcomes in patients with acute decompensated heart failure‐related cardiogenic shock Open

Anubodh S. Varshney, David D. Berg, Guohai Zhou, Lauren Sinnenberg, Sameer Hirji , et al. · 2023

Aims To describe outcomes associated with bridging strategies in patients with acute decompensated heart failure‐related cardiogenic shock (ADHF‐CS) bridged to durable left ventricular assist device (LVAD) or heart transplantation (HTx). M…

209. Epstein-Barr Virus Surveillance in Lung Transplantation: Post-transplant Lymphoproliferative Disorder and Impact on Survival Open

Andy Kim, Hilary J. Goldberg, Tany Thaniyavarn, John C. Kennedy, Antonio Coppolino , et al. · 2022

Background Epstein-Barr virus (EBV) donor seropositive/recipient seronegative (D+/R-) status is a risk factor for post-transplant lymphoproliferative disorder (PTLD) which is associated with increased mortality post-lung transplant. The op…

2123. The Impact of <i>Staphylococcus aureus</i> Peri-transplant Cultures on Six-Month Outcomes in Lung Transplantation Open

Courtney E. Harris, Abhinav Mehta, Andy Kim, Hilary J. Goldberg, Hari R. Mallidi , et al. · 2022

Background Staphylococcus aureus (S. aureus) infections post-lung transplant lead to increased mortality. The impact of S. aureus peri-transplant respiratory cultures on post-transplant outcomes is unknown as is the optimal duration of per…

The Cost-effectiveness of Transplanting Hearts From Hepatitis C-infected Donors Into Uninfected Recipients Open

Ann E. Woolley, Aditya R Gandhi, Michelle L. Jones, Jane J. Kim, Hari R. Mallidi , et al. · 2022

Background. The DONATE HCV trial demonstrated the safety and efficacy of transplanting hearts from hepatitis C viremic (HCV+) donors. In this report, we examine the cost-effectiveness and impact of universal HCV+ heart donor eligibility in…

IL-33 mediates Pseudomonas induced airway fibrogenesis and is associated with CLAD Open

Mudassir M. Banday, Sangeetha B Rao, Shruti Shankar, Mudasir A. Khanday, Jon Finan , et al. · 2022

Heart recovery and reverse remodeling following lung transplant in pulmonary artery hypertension Open

Hussain AlShimali, Antonio Coppolino, Mohamed A. Keshk, John S. Young, Akinobu Itoh , et al. · 2022

Antibody Responses to COVID-19 Vaccination in Left Ventricular Assist Devices Open

Karola Jering, Andy Kim, K.A. Frankel, Lara Coakley, Brittany Weber , et al. · 2022

WITHDRAWN Open

Karola Jering, Anthony Kim, K.A. Frankel, Lara Coakley, Brittany Weber , et al. · 2022

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm Open

Erica A. K. DePasquale, Daniel Ssozi, Marina Ainciburu, Jonathan Good, Jenny Noel , et al. · 2022

The immune system represents a major barrier to cancer progression, driving the evolution of immunoregulatory interactions between malignant cells and T-cells in the tumor environment. Blastic plasmacytoid dendritic cell neoplasm (BPDCN), …

Single-cell Multiomics Reveals Clonal T-cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm Open

Erica A. K. DePasquale, Daniel Ssozi, Marina Ainciburu, Jonathan Good, Jenny Noel , et al. · 2021

The immune system represents a major barrier to cancer progression, driving the evolution of immunoregulatory interactions between malignant cells and T-cells in the tumor environment. Blastic plasmacytoid dendritic cell neoplasms (BPDCN),…

94. Infectious Complications of Left Ventricular Assist Devices Open

Courtney E. Harris, Lara Coakley, Mandeep R. Mehra, Hari R. Mallidi, Lindsey R. Baden , et al. · 2021

Background Left ventricular assist devices (VAD) have significantly increased survival for patients with advanced heart failure. While advancements in devices during the past 10 years have improved thrombotic and bleeding complications, in…

1-year outcomes for lung transplantation recipients with non-alcoholic fatty liver disease Open

Anil J. Trindade, Tany Thaniyavarn, Nikroo Hashemi, Antonio Coppolino, John C. Kennedy , et al. · 2021

Advanced hepatic fibrosis and cirrhosis are absolute contraindications to lung transplantation. [ 1] However, whether fatty liver disease with mild–moderate fibrosis contributes to increased adverse outcomes post-lung transplantation remai…

Factors Associated with Very Long-Term Survival for Lung Transplant Recipients Open

Laura M. Piechura, Farhang Yazdchi, Morgan Harloff, Hunbo Shim, Nirmal Sharma , et al. · 2021

Long-Term Outcomes in Heart and Lung Transplants from HCV-Viremic Donors to Uninfected Recipients: The Donate HCV Trial Open

Ann E. Woolley, Hilary J. Goldberg, Steve K. Singh, Mandeep R. Mehra, Michael M. Givertz , et al. · 2021

Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality Open

Shyamal Asher, Gregory W Malzberg, Chin Siang Ong, Raymond Malapero, Huan Wang , et al. · 2020

OBJECTIVES Functional mitral regurgitation (MR) is observed with ischaemic heart disease or aortic valve disease. Assessing the value of mitral valve repair or replacement (MVR/P) is complicated by frequent discordance between preoperative…

Multimodality Curative Treatment of IIIA/T4 Lung Adenocarcinoma Open

Rohun Bhagat, Steven Swanson, Mark M. Hammer, Hari R. Mallidi, Abby White · 2020

COVID‐19 patient bridged to recovery with veno‐venous extracorporeal membrane oxygenation Open

Daniel Rinewalt, Anthony Coppolino, Raghu R. Seethala, Nirmal Sharma, Alí Salim , et al. · 2020

With proper patient selection and careful attention to hemodynamic management, ECMO remains a reasonable treatment option for patients with COVID-19.

Commentary: Magnetic resonance imaging for diagnosing vascular pathology Open

Laura M. Piechura, Ashraf A. Sabe, Hari R. Mallidi · 2020

Left ventricle unloading strategies in ECMO: A single‐center experience Open

Laura M. Piechura, Antonio Coppolino, Gita N. Mody, Daniel Rinewalt, M. Keshk , et al. · 2020

Based on this analysis, reactive unloading appears to be a viable strategy while venting with the Impella CP provides better than anticipated survival. Our findings correlate with recent large cohort studies and motivate further work to de…

COVID-19 Patient Bridged to Recovery with Veno-Venous Extracorporeal Membrane Oxygenation Open

Dan Rinewalt, Antonio Coppolino, Raghu R. Seethala, Nirmal Sharma, Alí Salim , et al. · 2020

Background: In severe cases, the COVID-19 viral pathogen produces hypoxic respiratory failure unable to be adequately supported by mechanical ventilation. The role of extracorporeal membrane oxygenation (ECMO) remains unknown, with the few…

Outcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty Open

Sameer Hirji, Farhang Yazdchi, Spencer Kiehm, S. Landino, Siobhan McGurk , et al. · 2020

The impact of hepatitis C viremic donor lung allograft characteristics on post-transplantation outcomes Open

Ann E. Woolley, Laura M. Piechura, Hilary J. Goldberg, Steve K. Singh, Antonio Coppolino , et al. · 2020

Despite a greater proportion of HCV-viremic donors being increased risk with a history of drug and cigarette use and having died as a result of drug intoxication, the quality of the HCV-viremic donor organs did not differ from the HCV-nega…

Sternotomy for lung transplantation: a description of technique Open

Antonio Coppolino, Gita N. Mody, Daniel Rinewalt, Emily Polhemus, Steve K. Singh , et al. · 2020

Sternotomy versus thoracotomy lung transplantation: key tips and contemporary results Open

Gita N. Mody, Anthony Coppolino, Steve K. Singh, Hari R. Mallidi · 2020

The purpose of this report is to provide an updated description of the technique of bilateral sequential lung transplant via median sternotomy. A sternotomy provides the advantage of less morbidity than the clamshell incision, as well as e…

Outside Facility Transfer Is Associated With Frequent Disposition to Rehabilitation Following Transcatheter Aortic Valve Replacement Open

Sameer A Hirj, Rohan Shah, Lily V. Saadat, Laura M. Piechura, Sary F. Aranki , et al. · 2019

Significant variability exists in disposition practices to non-home facilities following transcatheter aortic valve replacement (TAVR). Increased spending due to Post Acute Care Transfer (PACT) policies has led hospitals to scrutinize pati…

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