Hariklia Eleftherohorinou
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View article: Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study
Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study Open
View article: Correction to: Group A streptococcal disease in paediatric inpatients: a European perspective
Correction to: Group A streptococcal disease in paediatric inpatients: a European perspective Open
View article: Group A streptococcal disease in paediatric inpatients: a European perspective
Group A streptococcal disease in paediatric inpatients: a European perspective Open
View article: A machine learning model on Real World Data for predicting progression to Acute Respiratory Distress Syndrome (ARDS) among COVID-19 patients
A machine learning model on Real World Data for predicting progression to Acute Respiratory Distress Syndrome (ARDS) among COVID-19 patients Open
Introduction Identifying COVID-19 patients that are most likely to progress to a severe infection is crucial for optimizing care management and increasing the likelihood of survival. This study presents a machine learning model that predic…
View article: Using machine learning to examine drivers of inappropriate outpatient antibiotic prescribing in acute respiratory illnesses
Using machine learning to examine drivers of inappropriate outpatient antibiotic prescribing in acute respiratory illnesses Open
Using a machine-learning model, we examined drivers of antibiotic prescribing for antibiotic-inappropriate acute respiratory illnesses in a large US claims data set. Antibiotics were prescribed in 11% of the 42 million visits in our sample…
View article: Plasma lipid profiles discriminate bacterial from viral infection in febrile children
Plasma lipid profiles discriminate bacterial from viral infection in febrile children Open
View article: HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease
HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease Open
View article: Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease Open
View article: Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature
Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature Open
In this study, a 13-transcript blood gene expression signature distinguished KD from other febrile conditions. Diagnostic accuracy increased with certainty of clinical diagnosis. A test incorporating the 13-transcript disease risk score ma…
View article: Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study
Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study Open
View article: Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function
Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function Open
The WHO estimates around a million children contract tuberculosis (TB) annually with over 80 000 deaths from dissemination of infection outside of the lungs. The insidious onset and association with skin test anergy suggests failure of the…
View article: Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities
Genetic Variation in the SLC8A1 Calcium Signaling Pathway Is Associated With Susceptibility to Kawasaki Disease and Coronary Artery Abnormalities Open
Background— Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkag…
View article: Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies
Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies Open
View article: Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children
Diagnostic Test Accuracy of a 2-Transcript Host RNA Signature for Discriminating Bacterial vs Viral Infection in Febrile Children Open
Importance: Because clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment, while bacterial infection is missed in others. Objective: To identify a blo…