Harm J. Krugers
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View article: Coping strategies dynamics and resilience profiles after early life stress revealed by behavioral sequencing
Coping strategies dynamics and resilience profiles after early life stress revealed by behavioral sequencing Open
Animal models can provide valuable insights into the mechanisms underlying stress-related disorders. Yet, significant translational challenges persist, as laboratory behavioral assays are often reductionistic, with limited attention to eth…
View article: A novel approach to resilience and its links with education and Alzheimer's disease genetics
A novel approach to resilience and its links with education and Alzheimer's disease genetics Open
INTRODUCTION Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS We analyzed amyloid‐positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dement…
View article: Debate: Urban versus rural environments – which is better for mental health? <i>The one good thing about a small town…</i>
Debate: Urban versus rural environments – which is better for mental health? <i>The one good thing about a small town…</i> Open
Urban environments are related to higher prevalences of common mental disorders (addictions, anxieties and mood disorders) in adults. The mechanisms underlying this relationship are less clear. Cities function as a magnet, related to econo…
View article: A cross-sectional network analysis of successful aging in a resilience-based framework
A cross-sectional network analysis of successful aging in a resilience-based framework Open
Aging inevitably gives rise to many challenges and transitions that can greatly impact our (mental) well-being and quality of life if these are not controlled adequately. Hence, the key to successful aging may not be the absence of these s…
View article: How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms
How Can Early Stress Influence Later Alzheimer's Disease Risk? Possible Mediators and Underlying Mechanisms Open
View article: Neural correlates of learning and memory are altered by early-life stress
Neural correlates of learning and memory are altered by early-life stress Open
The ability to learn and remember, which is fundamental for behavioral adaptation, is susceptible to stressful experiences during the early postnatal period, such as abnormal levels of maternal care. The exact mechanisms underlying these e…
View article: Early-life stress impairs acquisition and retrieval of fear memories: sex-effects, corticosterone modulation, and partial prevention by targeting glucocorticoid receptors at adolescent age
Early-life stress impairs acquisition and retrieval of fear memories: sex-effects, corticosterone modulation, and partial prevention by targeting glucocorticoid receptors at adolescent age Open
The early postnatal period is a sensitive time window that is characterized by several neurodevelopmental processes that define neuronal architecture and function later in life. Here, we examined in young adult mice, using an auditory fear…
View article: Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism
Early‐life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism Open
INTRODUCTION Early‐life stress (ES) increases the risk for Alzheimer's disease (AD). We and others have shown that ES aggravates amyloid‐beta (Aβ) pathology and promotes cognitive dysfunction in APP/PS1 mice, but underlying mechanisms rema…
View article: Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer’s Disease
Identifying Cognitive Resilience Related Genes Among Genetic Risk Loci of Alzheimer’s Disease Open
Background Cognitive resilience (CR) in the context of Alzheimer’s disease (AD) describes the ability to maintain cognitive function despite the presence of neuropathology (Hohman et al., 2016). While most studies have focused on investiga…
View article: Shaping Memories via Stress: A Synaptic Engram Perspective
Shaping Memories via Stress: A Synaptic Engram Perspective Open
View article: Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice
Early Life Stress Enhances Cognitive Decline and Alters Synapse Function and Interneuron Numbers in Young Male APP/PS1 Mice Open
Background: Exposure to stress early in life increases the susceptibility to Alzheimer’s disease (AD) pathology in aged AD mouse models. So far, the underlying mechanisms have remained elusive. Objective: To investigate 1) effects of early…
View article: Resilience Among Older Individuals in the Face of Adversity: How Demographic and Trait Factors Affect Mental-Health Constructs and Their Temporal Dynamics
Resilience Among Older Individuals in the Face of Adversity: How Demographic and Trait Factors Affect Mental-Health Constructs and Their Temporal Dynamics Open
Resilience can be conceptualized as a network of interacting mental-health constructs characterized by weak autoconnections and/or interconnections. We investigated whether positive appraisal style (PAS), the ability to bounce back or reco…
View article: Corrigendum: The interplay between quality of life and resilience factors in later life: a network analysis
Corrigendum: The interplay between quality of life and resilience factors in later life: a network analysis Open
[This corrects the article DOI: 10.3389/fpsyg.2021.752564.].
View article: Improving goal striving and resilience in older adults through a personalized metacognitive self-help intervention: a protocol paper
Improving goal striving and resilience in older adults through a personalized metacognitive self-help intervention: a protocol paper Open
Background Successful aging is often linked to individual’s ability to demonstrate resilience: the maintenance or quick recovery of functional ability, well-being, and quality of life despite losses or adversity. A crucial element of resil…
View article: Are older individuals predisposed to habitual control more resilient?
Are older individuals predisposed to habitual control more resilient? Open
Based on evidence for age-related impairments in flexible, goal-directed control, the formation of habits has been recognized as an opportune route for behavioural adjustment that promotes resilience among older adults. The present study s…
View article: Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity
Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity Open
Glucocorticoids are potent memory modulators that can modify behavior in an adaptive or maladaptive manner. Elevated glucocorticoid levels after learning promote memory consolidation at recent time points, but their effects on remote time …
View article: Changes in perceived ageism during the COVID-19 pandemic: impact on quality of life and mental well-being among Dutch adults aged 55 and older
Changes in perceived ageism during the COVID-19 pandemic: impact on quality of life and mental well-being among Dutch adults aged 55 and older Open
Objectives: The COVID-19 pandemic brought ageism to the forefront of public discourse. Negative ageism incurs more negative self-perceptions of aging, which affects physical and mental functioning. Whether negative ageism as perceiv…
View article: Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins
Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteins Open
Epidemiological evidence indicates that early life stress (ES) exposure increases the risk for later-life diseases, such as Alzheimer’s disease (AD). Accordingly, we and others have shown that ES aggravates the development of, and response…
View article: The Subjective Experience of Ageism: The Perceived Ageism Questionnaire (PAQ)
The Subjective Experience of Ageism: The Perceived Ageism Questionnaire (PAQ) Open
Ageism as perceived by older individuals has been recognized as a potential risk factor for physical and mental health. We aimed to develop a comprehensive scale that can quantify perceived ageism among aging individuals (55+), including b…
View article: Application of a pharmacological transcriptome filter identifies a shortlist of mouse glucocorticoid receptor target genes associated with memory consolidation
Application of a pharmacological transcriptome filter identifies a shortlist of mouse glucocorticoid receptor target genes associated with memory consolidation Open
View article: Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility
Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility Open
While aging is an important risk factor for neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease, age-related cognitive decline can also manifest without apparent neurodegenerative changes. In this review, we dis…
View article: Psychological Coping and Behavioral Adjustment Among Older Adults in Times of COVID-19: Exploring the Protective Role of Working Memory and Habit Propensity
Psychological Coping and Behavioral Adjustment Among Older Adults in Times of COVID-19: Exploring the Protective Role of Working Memory and Habit Propensity Open
View article: Assessing the degree of urbanisation using a single-item self-report measure: a validation study
Assessing the degree of urbanisation using a single-item self-report measure: a validation study Open
The differential impact of rural versus urban residence on mental health remains a controversial topic that requires more in-depth investigations. This calls for a valid and easy measure to assess the degree of urbanisation. The purpose of…
View article: The Interplay Between Quality of Life and Resilience Factors in Later Life: A Network Analysis
The Interplay Between Quality of Life and Resilience Factors in Later Life: A Network Analysis Open
Age-related challenges and transitions can have considerable social, psychological, and physical consequences that may lead to significant changes in quality of life (QoL). As such, maintaining high levels of QoL in later life may cruciall…
View article: The Interplay between Quality of Life and Resilience Factors in Later Life: A Network Analysis
The Interplay between Quality of Life and Resilience Factors in Later Life: A Network Analysis Open
Age-related challenges and transitions can have considerable social, psychological, and physical consequences that may lead to significant changes in quality of life (QoL). As such, maintaining high levels of QoL in later life may cruciall…
View article: A Network Perspective on Successful Aging and Resilience in Later Life: A Protocol Paper
A Network Perspective on Successful Aging and Resilience in Later Life: A Protocol Paper Open
Aging inevitably gives rise to many late-life challenges and transitions that impose threats for one’s physical and mental health, which can greatly impact our well-being and quality of life. Hence, the key to successful aging may not be t…
View article: Ketamine treatment upon memory retrieval reduces fear memory in marmoset monkeys
Ketamine treatment upon memory retrieval reduces fear memory in marmoset monkeys Open
View article: Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population
Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population Open
View article: An emerging role for microglia in stress‐effects on memory
An emerging role for microglia in stress‐effects on memory Open
Stressful experiences evoke, among others, a rapid increase in brain (nor)epinephrine (NE) levels and a slower increase in glucocorticoid hormones (GCs) in the brain. Microglia are key regulators of neuronal function and contain receptors …
View article: Correction: How the COVID-19 pandemic highlights the necessity of animal research
Correction: How the COVID-19 pandemic highlights the necessity of animal research Open