Harmon Khela
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View article: Revision and Postoperative Complication Rates of Conversion Total Hip Arthroplasty after Cephalomedullary Nailing of Intertrochanteric Femur Fractures: A Systematic Review and Meta-Analysis
Revision and Postoperative Complication Rates of Conversion Total Hip Arthroplasty after Cephalomedullary Nailing of Intertrochanteric Femur Fractures: A Systematic Review and Meta-Analysis Open
Purpose Management of failed intertrochanteric (IT) fracture fixation often requires conversion total hip arthroplasty (cTHA), but complication and reoperation rates remain poorly characterized in the literature. This study aimed to charac…
View article: Effect of Mental Health Diagnoses on Postoperative Outcomes and Secondary Treatment Utilization After Surgery for Adhesive Capsulitis: A Retrospective Large Database Analysis
Effect of Mental Health Diagnoses on Postoperative Outcomes and Secondary Treatment Utilization After Surgery for Adhesive Capsulitis: A Retrospective Large Database Analysis Open
Introduction: Adhesive capsulitis (AC) is a debilitating condition that markedly affects shoulder mobility and function. Mental health disorders have been associated with poorer outcomes for orthopaedic patients; however, their specific ef…
View article: Poster 190: Adolescent Achilles Tendon Ruptures in the United States: An Evaluation of National Practice Patterns, Management Trends, Complications and 2-year Failure Rates
Poster 190: Adolescent Achilles Tendon Ruptures in the United States: An Evaluation of National Practice Patterns, Management Trends, Complications and 2-year Failure Rates Open
Objectives: Achilles tendon ruptures, though relatively uncommon in the adolescent population, present significant clinical challenges due to the unique biomechanical and physiological characteristics of developing tissues. While the manag…
View article: Indications, Technique, and Outcomes of Patient Specific Instrumentation for Osteotomy About the Knee
Indications, Technique, and Outcomes of Patient Specific Instrumentation for Osteotomy About the Knee Open
View article: Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum
Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum Open
Pituitary neuroendocrine tumors (PitNETs) are common intracranial neoplasms with complex biology underpinned by unresolved cellular origins, molecular heterogeneity, and microenvironment interactions. Here, we employ single-nuclei RNA-sequ…
View article: Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival Open
Asbstract Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remai…
View article: YouTube Videos on Lateral Epicondylitis Often Lack High-Quality, Reliable Information
YouTube Videos on Lateral Epicondylitis Often Lack High-Quality, Reliable Information Open
Lateral epicondylitis is a common condition that patients may research online. As the content on YouTube is continually increasing and its popularity remains high, it is important to continually investigate the quality of information avail…
View article: Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells
Regulatory T Cell Mimicry by a Subset of Mesenchymal GBM Stem Cells Suppresses CD4 and CD8 Cells Open
Attempts to activate an anti-tumor immune response in glioblastoma (GBM) have been met with many challenges due to its inherently immunosuppressive tumor microenvironment. The degree and mechanisms by which molecularly and phenotypically d…
View article: Imposter Syndrome Among Orthopaedic Surgery Residents is Extremely Common and Disproportionately Affects Female Residents
Imposter Syndrome Among Orthopaedic Surgery Residents is Extremely Common and Disproportionately Affects Female Residents Open
Introduction: Imposter syndrome is a psychological phenomenon in which individuals experience persistent self-doubt and feelings of inadequacy despite achieving objective measures of success. This phenomenon is associated with lower job sa…
View article: Comparison of Acute Orthopaedic Injuries From Cardiovascular Versus Strength Exercise in Adolescents and Young Adults to the Emergency Department: An Analysis of the National Electronic Injury Surveillance System Database, 2018-2022
Comparison of Acute Orthopaedic Injuries From Cardiovascular Versus Strength Exercise in Adolescents and Young Adults to the Emergency Department: An Analysis of the National Electronic Injury Surveillance System Database, 2018-2022 Open
Background: Adolescents and young adults comprise a growing cohort at risk for exercise-related injuries. Recent studies compare the effects of cardiovascular and strength exercise on mental health, cardiovascular disease, and mortality; h…
View article: TGFBR2<sup>High</sup>mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function
TGFBR2<sup>High</sup>mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function Open
Attempts to activate an anti-tumor immune response in glioblastoma (GBM) have been met with many challenges due to its inherently immunosuppressive tumor microenvironment. The degree and mechanisms by which molecularly and phenotypically d…
View article: miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming
miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming Open
Background/Objectives: CSCs are critical drivers of the tumor and stem cell phenotypes of glioblastoma (GBM) cells. Chromatin modifications play a fundamental role in driving a GBM CSC phenotype. The goal of this study is to further our un…
View article: Redefining precision: the current and future roles of artificial intelligence in spine surgery
Redefining precision: the current and future roles of artificial intelligence in spine surgery Open
The integration of artificial intelligence (AI) into spine surgery presents a transformative approach to preoperative and postoperative care paradigms. This paper explores the application of AI within spine surgery, focusing on diagnostic …
View article: BSBM-03 TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN
BSBM-03 TARGETABLE GENE EXPRESSION CHANGES MEDIATE EXTRAVASATION OF BREAST CANCER CELLS FROM THE CIRCULATION AND LOCAL PROLIFERATION IN THE BRAIN Open
As breast cancer migrates into the brain, it acquires distinct genomic, immunologic and phenotypic changes through interactions with the local microenvironment. We sought to determine how targetable gene expression changes mediate breast c…
View article: MDB-17. A COMPARISON OF MAGNETIC RESONANCE IMAGING AND CEREBROSPINAL FLUID CYTOLOGY FOR DETECTING LEPTOMENINGEAL METASTASIS IN PATIENTS WITH MEDULLOBLASTOMA
MDB-17. A COMPARISON OF MAGNETIC RESONANCE IMAGING AND CEREBROSPINAL FLUID CYTOLOGY FOR DETECTING LEPTOMENINGEAL METASTASIS IN PATIENTS WITH MEDULLOBLASTOMA Open
BACKGROUND For medulloblastoma, CSF cytology and MRI together are considered to be superior to either modality alone in identifying leptomeningeal dissemination (LMD). However, MRI has vastly improved since the initial assessment of this a…
View article: The Role of γδ T-Lymphocytes in Glioblastoma: Current Trends and Future Directions
The Role of γδ T-Lymphocytes in Glioblastoma: Current Trends and Future Directions Open
Cell-based immunotherapy for glioblastoma (GBM) encounters major challenges due to the infiltration-resistant and immunosuppressive tumor microenvironment (TME). γδ T cells, unconventional T cells expressing the characteristic γδ T cell re…
View article: The impact of attending historically Black colleges and universities on cognitive decline in Black adults: A longitudinal analysis in the KHANDLE and STAR cohorts
The impact of attending historically Black colleges and universities on cognitive decline in Black adults: A longitudinal analysis in the KHANDLE and STAR cohorts Open
INTRODUCTION Black students attending predominantly White institutions (PWIs) versus historically Black colleges and universities (HBCUs) report more harmful discrimination and develop worse mental health outcomes, potentially offsetting t…
View article: Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications Open
View article: A descriptive analysis of 2020 California Occupational Safety and Health Administration covid-19-related complaints
A descriptive analysis of 2020 California Occupational Safety and Health Administration covid-19-related complaints Open
COVID-19 mortality has disproportionately affected specific occupations and industries. The Occupational Safety and Health Administration (OSHA) protects the health and safety of workers by setting and enforcing standards for working condi…
View article: A descriptive analysis of 2020 California Occupational Safety and Health Administration COVID-19-related complaints
A descriptive analysis of 2020 California Occupational Safety and Health Administration COVID-19-related complaints Open
COVID-19 mortality disproportionately affected specific occupations and industries. The Occupational Safety and Health Administration (OSHA) protects the health and safety of workers by setting and enforcing standards for working condition…
View article: Biomarkers and focused ultrasound: the future of liquid biopsy for brain tumor patients
Biomarkers and focused ultrasound: the future of liquid biopsy for brain tumor patients Open
View article: Sox2 induces GBM cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
Sox2 induces GBM cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications Open
DNA methylation is a reversible process catalyzed by the ten-eleven translocation (TET) family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Altered patterns of 5hmC and 5mC are widely…
View article: STEM-27. miR-10b-5p MODULATES 5hmC EXPRESSION AND THE STEM-LIKE PHENOTYPE IN GBM
STEM-27. miR-10b-5p MODULATES 5hmC EXPRESSION AND THE STEM-LIKE PHENOTYPE IN GBM Open
Epigenetic alterations such as DNA methylation and dysregulation of non-coding RNAs (e.g. miRNAs) are found in all types of cancer and are thought to play important roles in tumorigenesis. GBM is characterized by small subsets of cells, re…
View article: Genetics of pediatric hearing loss: A functional perspective
Genetics of pediatric hearing loss: A functional perspective Open
Objectives This article reviews the current role of genetics in pediatric hearing loss (HL). Methods A review of the current literature regarding the genetic basis of HL in children was performed. Results To date, 119 nonsyndromic genes ha…