Explanipedia

Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction Open

Haoyu Sun, Matthew Muller, Harmony R. Reynolds, Tessa J. Barrett, Jeffrey S. Berger · 2025

Coronary endothelial dysfunction plays a key role in the pathogenesis of acute coronary syndromes. During myocardial infarction (MI), activated platelets release prothrombotic and proinflammatory factors, contributing to vascular injury an…

Angiography-Derived Versus Coronary Guidewire-Derived Index of Microcirculatory Resistance in Patients With Ischemia With Nonobstructive Coronary Arteries Open

Ethan Loftspring, Peter Zhang, William Beaty, Anaïs Hausvater, Amanda Joa , et al. · 2025

In patients with INOCA, correlations between IMR_angio and IMR were poor. IMR_angio appears unreliable for identifying CMD in patients with INOCA.

Impact of Heart Failure Guideline Publication on Medicare Drug Coverage Policies: A Quasi‐Experimental Analysis Open

Amrita Mukhopadhyay, Nathalia Ladino, Tyrel Stokes, Aparna Narendrula, Stuart D. Katz , et al. · 2025

Background Patients with heart failure (HF) often have difficulty obtaining life‐saving medications due to coverage barriers, such as prior authorizations and high out‐of‐pocket costs. To promote better coverage for high value therapies an…

Real‐World Evidence Linking the Predicting Risk of Cardiovascular Disease Events Risk Score and Coronary Artery Calcium Open

Aaron Rhee, Krutika Pandit, Jeffrey S. Berger, Eduardo Iturrate, Josef Coresh , et al. · 2025

Characterization and prognostic implication of pulmonary hypertension among patients with myeloproliferative neoplasms Open

Orly Leiva, Steven Soo, Olivia Liu, Nathaniel R. Smilowitz, Harmony R. Reynolds , et al. · 2025

Pulmonary hypertension (PH) is a frequent complication of Philadelphia-negative myeloproliferative neoplasms (MPN), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). However, its prognostic significa…

Invasive vs Conservative Management of Patients With Chronic Total Occlusion Open

Sripal Bangalore, G.B. John Mancini, Jonathan Leipsic, Matthew J. Budoff, Yifan Xu , et al. · 2025

Sex Differences in Psychosocial Factors and Angina in Patients With Chronic Coronary Disease Open

Anaïs Hausvater, Rebecca Anthopolos, Allan Seltzer, Tanya M. Spruill, John A. Spertus , et al. · 2025

Background Women with chronic coronary disease have more frequent angina and worse health status than men, despite having less coronary artery disease (CAD). We examined whether perceived stress and depressive symptoms mediate sex differen…

Brief Mindfulness-Based Cognitive Therapy in Women With Myocardial Infarction Open

Tanya M. Spruill, Chorong Park, Jolaade Kalinowski, Milla Arabadjian, Yuhe Xia , et al. · 2025

Strong association of stress cardiac magnetic resonance ischemia burden with cardiovascular events: post-hoc analysis from the ischemia trial Open

Raymond Y. Kwong, Bobby Heydari, Siddique Abbasi, François-Pierre Mongeon, Matthias Friedrich , et al. · 2025

Myocardial Infarction Platelet Gene Expression Signatures in Women Open

Tessa J. Barrett, Florencia Schlamp, Matthew Muller, Angela H Lee, MacIntosh Cornwell , et al. · 2024

Perceptions of HIV-Related Comorbidities and Usability of a Virtual Environment for Cardiovascular Disease Prevention Education in Sexual Minority Men With HIV: Formative Phases of a Pilot Randomized Controlled Trial Open

S. Raquel Ramos, Harmony R. Reynolds, Constance Johnson, Gail D’Eramo Melkus, Trace Kershaw , et al. · 2024

Background Sexual minority men with HIV are at an increased risk of cardiovascular disease (CVD) and have been underrepresented in behavioral research and clinical trials. Objective This study aims to explore perceptions of HIV-related com…

Comparison of Bayesian and frequentist monitoring boundaries motivated by the Multiplatform Randomized Clinical Trial Open

Jungnam Joo, Eric Leifer, Michael A. Proschan, James Troendle, Harmony R. Reynolds , et al. · 2024

Background The coronavirus disease 2019 pandemic highlighted the need to conduct efficient randomized clinical trials with interim monitoring guidelines for efficacy and futility. Several randomized coronavirus disease 2019 trials, includi…

C-20 | Assessing the Relationship between TIMI Frame Count and Index of Microvascular Resistance in Hemodynamically-Stratified Subgroups of Patients with Ischemia and Nonobstructive Coronary Arteries Open

Ethan Loftspring, Kenneth R. Harkin, Claudia Serrano-Gomez, Ayman Farid, Lindsay Elbaum , et al. · 2024

Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial Open

Radosław Pracoń, John A. Spertus, Samuel Broderick, Sripal Bangalore, Frank W. Rockhold , et al. · 2024

BACKGROUND: ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) did not find an overall reduction in cardiovascular events with an initial invasive versus conservative management strategy…

Visual Estimates of Coronary Slow Flow Are Not Associated With Invasive Wire-Based Diagnoses of Coronary Microvascular Dysfunction Open

Kenneth L. Harkin, Ethan Loftspring, William Beaty, Amanda Joa, Claudia Serrano-Gomez , et al. · 2024

BACKGROUND: Coronary slow flow (CSF) by invasive coronary angiography is frequently understood to be an indicator of coronary microvascular dysfunction (CMD) in patients with ischemia with nonobstructive coronary arteries. However, the rel…

Variation in Health Status With Invasive vs Conservative Management of Chronic Coronary Disease Open

Suzanne V. Arnold, Philip G. Jones, David J. Maron, David J. Cohen, Daniel B. Mark , et al. · 2024

Comparative Prognostic Utility of Coronary CT and Invasive Angiography Open

Jonathon Leipsic, Sagit Ben Zekry, Γεώργιος Τζίμας, Samuel Broderick, G.B. John Mancini , et al. · 2024

Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial Open

Harmony R. Reynolds, Derek D. Cyr, C. Noel Bairey Merz, Leslee J. Shaw, Bernard Chaitman , et al. · 2024

Background Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline‐directed medical therapy, and outcomes among pati…

Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19 Open

Lucas C. Godoy, Matthew D. Neal, Ewan C. Goligher, Mary Cushman, Brett L. Houston , et al. · 2024

Reallocating time between device-measured 24-hour activities and cardiovascular risk in Asian American immigrant women: An isotemporal substitution model Open

Chorong Park, Britta Larsen, Simona C. Kwon, Yuhe Xia, Marianna LaNoue , et al. · 2024

The 24-hour day consists of physical activity (PA), sedentary behavior, and sleep, and changing the time spent on one activity affects the others. Little is known about the impact of such changes on cardiovascular risk, particularly in Asi…

Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention Open

Makoto Araki, Seung‐Jung Park, Harold L. Dauerman, Shiro Uemura, Jung‐Sun Kim , et al. · 2023

Impact of Visit Volume on the Effectiveness of Electronic Tools to Improve Heart Failure Care Open

Amrita Mukhopadhyay, Harmony R. Reynolds, William C. King, Lawrence M. Phillips, Arielle R. Nagler , et al. · 2023

Psychosocial Factors of Women Presenting With Myocardial Infarction With or Without Obstructive Coronary Arteries Open

Anaïs Hausvater, Tanya M. Spruill, Yuhe Xia, Nathaniel R. Smilowitz, Milla Arabadjian , et al. · 2023

LB 01.5 Effect of the P-selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial Open

Charles J. Lowenstein, Scott D. Solomon, Ankeet S. Bhatt, Alexander Peikert, Orly Vardeny , et al. · 2023

Global Longitudinal Strain as Predictor of Inducible Ischemia in No Obstructive Coronary Artery Disease in the CIAO-ISCHEMIA Study Open

Esther Davis, Daniela R. Crousillat, Jesús Peteiro, José Luis López-Sendón, Roxy Senior , et al. · 2023

Biomarkers and cardiovascular events in patients with stable coronary disease in the ISCHEMIA Trials Open

Jonathan Newman, Rebecca Anthopolos, Kelly V. Ruggles, MacIntosh Cornwell, Harmony R. Reynolds , et al. · 2023

Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial Open

Nathaniel R. Smilowitz, Erinn M. Hade, Lucy Z. Kornblith, Lana A. Castellucci, Mary Cushman , et al. · 2023

Therapeutic-dose heparin was associated with a high probability of superiority to reduce the incidence of in-hospital severe AKI or death in patients hospitalized for COVID-19.

Impact of Complete Revascularization in the ISCHEMIA Trial Open

Gregg W. Stone, Ziad A. Ali, Sean M. O’Brien, Grace L. Rhodes, Philippe Généreux , et al. · 2023

Complete Revascularization and Angina-Related Health Status in the ISCHEMIA Trial Open

Kreton Mavromatis, Philip G. Jones, Ziad A. Ali, Gregg W. Stone, Grace M. Rhodes , et al. · 2023

Characteristics of Premature Myocardial Infarction Among Women With Prior Adverse Pregnancy Outcomes Open

Malamo Countouris, Agnes Koczo, Harmony R. Reynolds, Anaïs Hausvater, Harnoor Mann , et al. · 2023

Among women with premature MIs, 39% had a history of an APO. Women with APO history presented sooner after pregnancy but had similar MI characteristics vs those without APOs. Pregnancy history may identify women who warrant early, aggressi…

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