Harold E. Windschitl
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Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer Open
Colon tumors with defective DNA mismatch repair (dMMR) have a well characterized phenotype and accounts for ~15–20% of sporadic colon cancer (CC) as well as those colon cancer patients with Lynch Syndrome. Although the presence of dMMR app…
Long-Term Survivors of Metastatic Colorectal Cancer Treated with Systemic Chemotherapy Alone: A North Central Cancer Treatment Group Review of 3811 Patients, N0144 Open
Although systemic chemotherapy in patients with unresectable metastatic colorectal cancer (mCRC) is palliative in nature, some patients experience long-term remission beyond 5 years consequent to treatment with chemotherapy alone.
Phase II Study of Everolimus in Metastatic Malignant Melanoma (NCCTG-N0377, Alliance) Open
Lessons Learned Everolimus does not have sufficient activity to justify its use as single agent in metastatic melanoma. Patients treated with 10 mg per day dose were most likely to require dose reductions. Everolimus appeared to reduce the…