Helen Cooper
YOU?
Author Swipe
View article: Oasis Aging in Place: An Innovative National Model Supporting Healthy Aging - Lessons and Successes from Growth and Expansion
Oasis Aging in Place: An Innovative National Model Supporting Healthy Aging - Lessons and Successes from Growth and Expansion Open
Background: Over the next 20 years, Canada older adult population (aged 65 years old) is expected to grow by 68%. Older adults face isolation, loneliness, inadequate nutrition, and lack of physical activity which continue to be serious and…
View article: RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling
RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling Open
Structural plasticity, the ability of dendritic spines to change their volume in response to synaptic stimulation, is an essential determinant of synaptic strength and long-term potentiation (LTP), the proposed cellular substrate for learn…
View article: Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development
Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development Open
DNA methylation in neurons is directly linked to neuronal genome regulation and maturation. Unlike other tissues, vertebrate neurons accumulate high levels of atypical DNA methylation in the CH sequence context (mCH) during early postnatal…
View article: Hydrocephalus in Nfix−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology
Hydrocephalus in Nfix−/− Mice Is Underpinned by Changes in Ependymal Cell Physiology Open
Nuclear factor one X (NFIX) is a transcription factor required for normal ependymal development. Constitutive loss of Nfix in mice (Nfix−/−) is associated with hydrocephalus and sloughing of the dorsal ependyma within the lateral ventricle…
View article: Impact of COVID-19 lockdowns on hospital presentations and admissions in the context of low community transmission: evidence from time series analysis in Melbourne, Australia
Impact of COVID-19 lockdowns on hospital presentations and admissions in the context of low community transmission: evidence from time series analysis in Melbourne, Australia Open
Background Melbourne, Australia, successfully halted exponential transmission of COVID-19 via two strict lockdowns during 2020. The impact of such restrictions on healthcare-seeking behaviour is not comprehensively understood, but is of gl…
View article: Severe neonatal MEGDHEL syndrome with a homozygous truncating mutation in SERAC1
Severe neonatal MEGDHEL syndrome with a homozygous truncating mutation in SERAC1 Open
In the diagnostic work-up of a newborn infant with a metabolic crisis, lethal multiorgan failure on day six of life, and increased excretion of 3-methylglutaconic acid, we found using whole genome sequencing a homozygous SERAC1 mutation in…
View article: Acknowledgements
Acknowledgements Open
Featuring twelve original essays by leading Beckett scholars and media theorists, this book provides the first sustained examination of the relationship between Beckett and media technologies. The chapters analyse the rich variety of techn…
View article: <i>Pkd1</i> and <i>Wnt5a</i> genetically interact to control lymphatic vascular morphogenesis in mice
<i>Pkd1</i> and <i>Wnt5a</i> genetically interact to control lymphatic vascular morphogenesis in mice Open
Background Lymphatic vascular development is regulated by well‐characterized signaling and transcriptional pathways. These pathways regulate lymphatic endothelial cell (LEC) migration, motility, polarity, and morphogenesis. Canonical and n…
View article: DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation Open
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus ca…
View article: <i>Pkd1</i>and<i>Wnt5a</i>genetically interact to control lymphatic vascular morphogenesis in mice
<i>Pkd1</i>and<i>Wnt5a</i>genetically interact to control lymphatic vascular morphogenesis in mice Open
Lymphatic vascular development is regulated by well-characterised signalling and transcriptional pathways. These pathways regulate lymphatic endothelial cell (LEC) migration, motility, polarity and and morphogenesis. Canonical and non-cano…
View article: The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
The DCC receptor regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation Open
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus ca…
View article: Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1
Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1 Open
The fine arrangement of neuronal connectivity during development involves the coordinated action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still developing, with mesolimbic dopamine axons undergoing ta…
View article: Adherens Junctions: Guardians of Cortical Development
Adherens Junctions: Guardians of Cortical Development Open
Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex. The establishment of a highly apicobasally …
View article: Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons
Conserved and divergent features of DNA methylation in embryonic stem cell-derived neurons Open
DNA methylation functions in genome regulation and is implicated in neuronal maturation. Early post-natal accumulation of atypical non-CG methylation (mCH) occurs in neurons of mice and humans, but its precise function remains unknown. Her…
View article: Data to accompany "Electroporation and mass spectrometry: A new paradigm for in situ analysis of intact proteins direct from living yeast colonies"
Data to accompany "Electroporation and mass spectrometry: A new paradigm for in situ analysis of intact proteins direct from living yeast colonies" Open
Data to accompany Electroporation and mass spectrometry: A new paradigm for in situ analysis of intact proteins direct from living yeast colonies
View article: WNT5a Regulates Epithelial Morphogenesis in the Developing Choroid Plexus
WNT5a Regulates Epithelial Morphogenesis in the Developing Choroid Plexus Open
The choroid plexus (CP) is the predominant supplier of cerebral spinal fluid (CSF) and the site of the blood–CSF barrier and is thus essential for brain development and central nervous system homeostasis. Despite these crucial roles, our u…
View article: Notes on contributors
Notes on contributors Open
the Study of Literature and the Environment.His research examines strange and beautiful things that challenge the imagination, phenomena that seem alien and intimate at once.He is especially interested in what monsters, inhuman forces, and…
View article: Who Makes the Grade? Research Comparing Self, Peer and Instructor Grades in College
Who Makes the Grade? Research Comparing Self, Peer and Instructor Grades in College Open
With the increase in large college classes and online education, student grading of their own work and that of peers is also increasing in frequency. This meta-analysis of 36 studies and 103 effect sizes examined several questions regardin…
View article: Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere Open
In this Communication, a La Trobe University affiliation is missing for the author David A. Winkler. The penultimate author address entry must read: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 (Australia…
View article: 23.1 UNDERSTANDING THE ROLE OF SCHIZOPHRENIA/AUTISM GENES IN CORTICAL DEVELOPMENT
23.1 UNDERSTANDING THE ROLE OF SCHIZOPHRENIA/AUTISM GENES IN CORTICAL DEVELOPMENT Open
The fidelity of neocortical development is dependent on the highly polarized morphology of the neuroepithelial stem cell (NSC) within the embryonic brain. NSCs project long processes to the pial surface along which newborn neurons migrate …
View article: Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis
Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis Open
Hippocampal neurogenesis in the dentate gyrus (DG) is controlled by diffusible molecules that modulate neurogenic processes, including cell proliferation, differentiation and survival. To elucidate the mechanisms underlying hippocampal neu…