Harry Marquis
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View article: Extravasation Frequency of [<sup>177</sup>Lu]Lu-DOTATATE: Insights and Implications Derived from 1,314 Cycles of Treated Patients—A Single-Site Analysis
Extravasation Frequency of [<sup>177</sup>Lu]Lu-DOTATATE: Insights and Implications Derived from 1,314 Cycles of Treated Patients—A Single-Site Analysis Open
Extravasation of radiopharmaceuticals raises potential concerns, including adverse tissue reactions and reduction in both quantitative accuracy and therapeutic efficacy. This study presents a single-center experience reviewing extravasatio…
View article: MIRD Pamphlet No. 30: MIRDfit—A Tool for Fitting of Biodistribution Time–Activity Data for Internal Dosimetry
MIRD Pamphlet No. 30: MIRDfit—A Tool for Fitting of Biodistribution Time–Activity Data for Internal Dosimetry Open
In nuclear medicine, estimating the number of radioactive decays that occur in a source organ per unit administered activity of a radiopharmaceutical (i.e., the time-integrated activity coefficient [TIAC]) is an essential task within the i…
View article: MIRD Pamphlet No. 29: MIRDy90—A<sup>90</sup>Y Research Microsphere Dosimetry Tool
MIRD Pamphlet No. 29: MIRDy90—A<sup>90</sup>Y Research Microsphere Dosimetry Tool Open
90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporat…
View article: The risk index as a basis for risk/benefit analyses and protocol optimization in diagnostic nuclear imaging
The risk index as a basis for risk/benefit analyses and protocol optimization in diagnostic nuclear imaging Open
Background Potential risk associated with low‐dose radiation exposures is often expressed using the effective dose ( E ) quantity. Other risk‐related quantities have been proposed as alternatives. The recently introduced risk index ( RI ) …
View article: Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates
Investigation and optimization of PET-guided SPECT reconstructions for improved radionuclide therapy dosimetry estimates Open
Introduction To investigate and optimize the SPECTRE (Single Photon Emission Computed Theranostic REconstruction) reconstruction approach, using the hybrid kernelised expectation maximization (HKEM) algorithm implemented in the software fo…
View article: Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates.
Partial volume effect in SPECT & PET imaging and impact on radionuclide dosimetry estimates. Open
The partial volume effect remains a significant factor when estimating radionuclide uptake in vivo, especially in small volumes. Accurate estimates of absorbed dose from radionuclide therapy will be particularly challenging until robust so…
View article: Dosimetric Variability Across a Library of Computational Tumor Phantoms
Dosimetric Variability Across a Library of Computational Tumor Phantoms Open
In radiopharmaceutical therapy, dosimetry-based treatment planning and response evaluation require accurate estimates of tumor-absorbed dose. Tumor dose estimates are routinely derived using simplistic spherical models, despite the well-es…
View article: <sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry
<sup>64</sup>Cu Treatment Planning and<sup>67</sup>Cu Therapy with Radiolabeled [<sup>64</sup>Cu/<sup>67</sup>Cu]MeCOSar-Octreotate in Subjects with Unresectable Multifocal Meningioma: Initial Results for Human Imaging, Safety, Biodistribution, and Radiation Dosimetry Open
Our aim was to report the use of 64Cu and 67Cu as a theranostic pair of radionuclides in human subjects. An additional aim was to measure whole-organ dosimetry of 64Cu and 67Cu attached to the so…
View article: Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry
Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry Open
Background SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modelling (RM) into the SPE…
View article: Overlooked potential of positrons in cancer therapy
Overlooked potential of positrons in cancer therapy Open