Harry Nugroho Eko Surniyantoro
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View article: Preliminary Study of Spontaneous Micronuclei and Hematology Profile of Workers Exposed to Low-Dose Radiation
Preliminary Study of Spontaneous Micronuclei and Hematology Profile of Workers Exposed to Low-Dose Radiation Open
The data obtained here showed an increased risk of genetic instability correlated with occupation, exposure time, and dose received by radiation workers. This study's conclusions are significant, as they demonstrate that long-term exposure…
View article: Gamma-H2AX as a biomarker to assess individual radiosensitivity for radiopharmaceutical therapy in cancer patients: a systematic review
Gamma-H2AX as a biomarker to assess individual radiosensitivity for radiopharmaceutical therapy in cancer patients: a systematic review Open
Radiopharmaceutical therapy offers targeted and potent cancer treatment, but individual responses vary, necessitating personalized approaches for optimal outcomes. Gamma-H2AX, a phosphorylated form of histone, has become a sensitive indica…
View article: Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition
Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition Open
The radioprotective potential of Sitahe ( Leuconotis eugenifolia ) phytochemicals in cancer radiotherapy remains largely unexplored. In this study, in silico docking simulations were conducted to systematically assess the ability of key ph…
View article: IL-6 and IL-10 Levels in Rats Blood Plasma as Immune Responses Post Radioiodine (I-131) Administration
IL-6 and IL-10 Levels in Rats Blood Plasma as Immune Responses Post Radioiodine (I-131) Administration Open
The highest increase in IL-6 and IL-10 levels occurred respectively in the first 0.5 hours 8 times and in the first 0.25 hours 1.47 times compared to controls. Internal irradiation with radioiodine resulted in a significant increase in imm…
View article: Association of C-262T (rs1001179) genetic polymorphism and catalase level in medical radiation workers
Association of C-262T (rs1001179) genetic polymorphism and catalase level in medical radiation workers Open
The human body has a defense system to fight free radicals that can damage body tissues biochemically. The molecules formed are antioxidants whose role is to protect the body from superoxide radical ions. One of these antioxidantsis catala…
View article: The potential effect of temulawak (<i>Curcuma xanthorrhiza</i> Roxb.) and garlic (<i>Allium sativum</i> L.) as a radioprotective agent against 6 Gy total body irradiation in rats
The potential effect of temulawak (<i>Curcuma xanthorrhiza</i> Roxb.) and garlic (<i>Allium sativum</i> L.) as a radioprotective agent against 6 Gy total body irradiation in rats Open
The main impact of gamma radiation on a biological system is the formation of Reactive Oxygen Species (ROS) and free radicals. The study aimed to explore the potential effect of temulawak ( Curcuma xanthorrhiza Roxb.) and garlic ( Allium s…
View article: Micronucleus assay in the blood of residents in Mamuju, West Sulawesi, Indonesia, a high background radiation area
Micronucleus assay in the blood of residents in Mamuju, West Sulawesi, Indonesia, a high background radiation area Open
Micronucleus assay in the blood of residents in Mamuju, West Sulawesi, Indonesia, a high background radiation area
View article: Car-borne Survey and Dose Assessment from External Radiation Exposure in Bangka Island
Car-borne Survey and Dose Assessment from External Radiation Exposure in Bangka Island Open
Bangka Island with a history of more than 200 years of tin mining, has brought along the byproduct of heavy minerals which contain radionuclide elements. There are some concerns about this byproduct material contributing to natural radiati…
View article: Study of Immune Response and Malondialdehyde Levels in Irradiated Rats Supplemented with Curcuma xanthorriza Roxb Extract
Study of Immune Response and Malondialdehyde Levels in Irradiated Rats Supplemented with Curcuma xanthorriza Roxb Extract Open
The administration of Curcuma xanthorriza Xorb extract was able to reduce MDA concentrations in the liver and spleen although not statistically significant. In addition, exposure to ionizing radiation at a dose of 6 Gy significantly increa…
View article: Assessment of hOGG1 Genetic Polymorphism (rs1052133) and DNA Damage in Radiation-Exposed Workers
Assessment of hOGG1 Genetic Polymorphism (rs1052133) and DNA Damage in Radiation-Exposed Workers Open
The single-nucleotide polymorphism of hOGG1 exon 7 (rs1052133) demonstrated no association with the extent of DNA damage in radiation-exposed workers.
View article: Adaptive Response of Peripheral Blood Lymphocytes in Medical Radiation Workers using the Comet Assay: A Preliminary Studyomet Assay: A Preliminary Study
Adaptive Response of Peripheral Blood Lymphocytes in Medical Radiation Workers using the Comet Assay: A Preliminary Studyomet Assay: A Preliminary Study Open
Background: Gamma irradiation can cause DNA damage in single and double-strand breaks (SSBs & DSBs), especially in peripheral blood lymphocytes. Radiotherapy medical radiation workers can be exposed to gamma radiation related to their dail…
View article: Evaluation of Spontaneous DNA Damage Using the Alkaline Comet Assay in Lymphocyte Cells of Humans Living in the High Level Natural Radiation Area of Mamuju, Indonesia
Evaluation of Spontaneous DNA Damage Using the Alkaline Comet Assay in Lymphocyte Cells of Humans Living in the High Level Natural Radiation Area of Mamuju, Indonesia Open
To evaluate the biological impacts of high background radiation exposures that are represented by spontaneous deoxyribonucleic acid (DNA) damage, an evaluation on lymphocyte cells from residents of Mamuju, West Sulawesi, Indonesia was test…
View article: The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents
The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents Open
The immune system is one of the most significant defenses against environmental insults including natural radiation. The purpose of this preliminary study was to assess the effects of high natural radiation to Mamuju residents, by focusing…
View article: The Evaluation of Frequencies of Cytogenetic Biomarkers in Lymphocyte of Residents from High Natural Radiation Area in West Sulawesi, Indonesia
The Evaluation of Frequencies of Cytogenetic Biomarkers in Lymphocyte of Residents from High Natural Radiation Area in West Sulawesi, Indonesia Open
Residents living in high natural radiation areas may pose health consequences such as cancer. The study aims to evaluate the frequencies of cytogenetic biomarkers covering micronuclei (MN), nucleoplasmic bridge (NPB), and nuclear bud (NBUD…
View article: Worker Health Monitoring Through Whole Body Counter Examination for Safety and Radiation Protection (2017-2019 Data)
Worker Health Monitoring Through Whole Body Counter Examination for Safety and Radiation Protection (2017-2019 Data) Open
Radiation protection is an action or effort taken to reduce the effects of damaging radiation exposure. Therefore, it is necessary to routinely monitor the condition of workers, among others, with a whole-body counter (WBC) either for dail…
View article: Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia
Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia Open
One of the important DNA repair pathways is base excision repair (BER), which plays in the human body to maintain DNA integrity, prevent cancer and DNA damage. X-ray repair cross-complementing group 1 (XRCC1) is the most important DNA repa…
View article: The Cytogenetic Effects on Peripheral Blood Lymphocytes in Cancer Patients After Radiation Therapy: Chromosome Aberrations and Micronuclei
The Cytogenetic Effects on Peripheral Blood Lymphocytes in Cancer Patients After Radiation Therapy: Chromosome Aberrations and Micronuclei Open
Individual responses to radiotherapy are often observed whether or not regimes with identical treatments were applied. Patient-related factors, the therapeutic process, and therefore the intrinsic factors of individual radiosensitivity are…
View article: Preliminary study in genetic polymorphism of hOGG1 and risk factor for thyroid cancer in Indonesia
Preliminary study in genetic polymorphism of hOGG1 and risk factor for thyroid cancer in Indonesia Open
The human 8-oxoguanine DNA N-glycosylase-1 (hOGG1) is the most important DNA repair enzyme in base excision repair (BER) pathways and has been reported to have a relationship with the risk of developing various cancers. The study was aimed…
View article: Alkaline Comet Assay as a Predictor of DNA Damage in Medical Radiation Workers
Alkaline Comet Assay as a Predictor of DNA Damage in Medical Radiation Workers Open
The study was aimed to examine the deoxyribonucleic acid (DNA) damage level between medical and non-medical radiation workers using the comet assay method. The radiation-exposed group (29 subjects) and the control group (29 subjects) were …
View article: Detection of the Resistance of Parasite to Sulfadoxine-pyrimethamine Drugs and msp-2 Genotyping as A Baseline in Developing Malaria Vaccine with Ionizing Radiation
Detection of the Resistance of Parasite to Sulfadoxine-pyrimethamine Drugs and msp-2 Genotyping as A Baseline in Developing Malaria Vaccine with Ionizing Radiation Open
Polymorphism or mutation in specific genes of P. falciparum and P. vivax is involved in the resistance to sulfadoxine-pyrimethamine (SP) antimalarial drug . On the other hand msp-2 gene plays an important role in drug resistance rel…
View article: Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers
Assessment of Ionizing Radiation Effects on the Hematological Parameters of Radiation-Exposed Workers Open
Long-term exposure to low doses of ionizing radiation may adversely affect human cells and tissues of hospital radiation workers, especially peripheral blood cell count. Blood cell count analysis is a useful screening test in a routine med…
View article: Interaction of Arg194Trp and Arg399Gln genotypes with the risk of radiation on cancer patients
Interaction of Arg194Trp and Arg399Gln genotypes with the risk of radiation on cancer patients Open
Surniyantoro HNE, Rahajeng N, Lusiyanti Y, Rahardjo T, Erawati D, Choridah L, Dhamiyati W, Dwidanarti SR. 2019. Interaction of Arg194Trp and Arg399Gln genotypes with the risk of radiation on cancer patients. Biodiversitas 20: 2128-2133. Tw…
View article: A mutant variant of Nix gene on γ-irradiated Aedes aegypti as a male-determination factor
A mutant variant of Nix gene on γ-irradiated Aedes aegypti as a male-determination factor Open
Ernawan B, Surniyantoro HNE, Sugoro I, Tambunan USF. 2019. A mutant variant of Nix gene on γ-irradiated Aedes aegypti as a male-determination factor. Biodiversitas 20: 893-899. This study was aimed to examine the effect of γ-irradiation on…
View article: Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers
Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers Open
X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand breaks. Individuals with XRCC1 exon 10 (Arg399Gln) gen…
View article: Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers
Genetic polymorphism in DNA base excision repair gene XRCC1among medical radiation workers Open
X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand breaks. Individuals with XRCC1 exon 10 (Arg399Gln) gen…
View article: Uncoupling Protein 2 (UCP2) as Genetic Risk Factor for Obesity in Indonesia is Different in Gender Stratification.
Uncoupling Protein 2 (UCP2) as Genetic Risk Factor for Obesity in Indonesia is Different in Gender Stratification. Open
Ala55Val and 45 basepair (bp) insertion/deletion (I/D) of UCP2 gene polymorphisms cause a decrease in resting energy expenditure, decreasing fatty acid oxidation and influencing mRNA transcription and stability, thereby increasing the risk…
View article: Association between XRCC1 exon 10 (Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers
Association between XRCC1 exon 10 (Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers Open
Surniyantoro HNE, Lusiyanti Y, Rahardjo T, Nurhayati S, Tetriana D. 2018. Association between XRCC1 exon 10 (Arg399Gln) gene polymorphism and micronucleus as a predictor of DNA damage among radiation workers. Biodiversitas 19: 1676-1682. T…
View article: Polymorphism of XRCC1 Gene Exon 6 (Arg194Trp) in Relation to Micronucleus Frequencies in Hospital Radiation Workers
Polymorphism of XRCC1 Gene Exon 6 (Arg194Trp) in Relation to Micronucleus Frequencies in Hospital Radiation Workers Open
The genetic polymorphism of DNA repair gene plays some important role in regulating individual sensitivity to ionizing radiation, maintaining DNA integrity, and preventing cancer and DNA damage.XRCC1 as one of the members ofbase excision r…