Harsh Bansia
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View article: Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models
Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models Open
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a coreceptor for NGF and tropomyosin-related k…
View article: Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy Open
Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we report the first structural insights into the fu…
View article: Identification of a 1‐acyl‐glycerol‐3‐phosphate acyltransferase from <i>Mycobacterium tuberculosis</i>, a key enzyme involved in triacylglycerol biosynthesis
Identification of a 1‐acyl‐glycerol‐3‐phosphate acyltransferase from <i>Mycobacterium tuberculosis</i>, a key enzyme involved in triacylglycerol biosynthesis Open
Latent tuberculosis, caused by dormant Mycobacterium tuberculosis ( Mtb ), poses a threat to global health through the incubation of undiagnosed infections within the community. Dormant Mtb , which is phenotypically tolerant to antibiotics…
View article: Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain
Neuropilin-1 is a co-receptor for Nerve Growth Factor-evoked pain Open
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain yet, failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a co-receptor for NGF and tropomyosin-related …
View article: Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster
Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster Open
Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases of severe disease. However, perpetual viral evolution has required continuous ef…
View article: Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing
Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing Open
The clinical manufacturing of chimeric antigen receptor (CAR) T cells includes cell selection, activation, gene transduction, and expansion. While the method of T-cell selection varies across companies, current methods do not actively elim…
View article: Investigating gating mechanisms of ion channels using temperature-resolved cryoEM
Investigating gating mechanisms of ion channels using temperature-resolved cryoEM Open
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View article: Mycobacterium tuberculosis Calcium Pump CtpF Modulates the Autophagosome in an mTOR-Dependent Manner
Mycobacterium tuberculosis Calcium Pump CtpF Modulates the Autophagosome in an mTOR-Dependent Manner Open
Calcium is a very important second messenger, whose concentration in various cellular compartments is under tight regulation. A disturbance in the levels of calcium in these compartments can play havoc in the cell, as it regulates various …
View article: Small Glycols Discover Cryptic Pockets on Proteins for Fragment-based Approaches
Small Glycols Discover Cryptic Pockets on Proteins for Fragment-based Approaches Open
Cryptic pockets are visible in ligand-bound protein structures but are occluded in unbound structures. Utilizing these pockets in fragment-based drug-design provides an attractive option for proteins not tractable by classical binding site…
View article: Structural basis for neutralization of cytotoxic abrin by monoclonal antibody D6F10
Structural basis for neutralization of cytotoxic abrin by monoclonal antibody D6F10 Open
Abrin, an extremely cytotoxic Type II ribosome‐inactivating protein ( RIP ), is a potential bio‐warfare agent. Abrin A‐chain ( ABA ) depurinates an adenosine of sarcin‐ricin loop ( SRL ) from eukaryotic 28S rRNA , thereby arresting protein…
View article: Certain small glycols as cryptic pocket finders in proteins
Certain small glycols as cryptic pocket finders in proteins Open
Cryptic pockets are sites on proteins which are not apparent in the unliganded form of proteins [1].They become visible only when a small molecule/inhibitor/drug binds to its target site on protein and are considered important from the per…