Hartmut Ruetten
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View article: A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study
A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study Open
Objective To delineate organ-specific and systemic drivers of metabolic dysfunction-associated steatotic liver disease (MASLD), we applied integrative causal inference across clinical, imaging, and proteomic domains in individuals with and…
View article: Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits Open
View article: Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models Open
View article: The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits Open
View article: Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials Open
View article: Pharmacogenomics of GLP-1 Receptor Agonists: A genome wide analysis of observational data and large randomized controlled trials
Pharmacogenomics of GLP-1 Receptor Agonists: A genome wide analysis of observational data and large randomized controlled trials Open
Summary Background In the treatment of type 2 diabetes (T2D), GLP-1 Receptor Agonists (GLP-1RA) lower glucose levels and body weight, and have cardiovascular benefits. GLP-1RA efficacy and side effects vary between people. Human pharmacoge…
View article: Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study Open
View article: Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study
Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study Open
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and m…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured.…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N=2111) underwent 2h-75g OGTT at baseline and 48 months. HbA1c was also measured.…
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 mo…
View article: Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study Open
Genetic variants identified by genome-wide association studies can contribute to disease risk by altering the production and abundance of mRNA, proteins and other molecules. However, the interplay between molecular intermediaries that defi…
View article: Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF Open
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
Objective We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). Research Design and Methods 732 recently diagnosed T2D patients from the IMI-DIRECT study were extensively phenotyped over…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
Objective We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). Research Design and Methods 732 recently diagnosed T2D patients from the IMI-DIRECT study were extensively phenotyped over…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research …
View article: Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Open
View article: Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study Open
Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-…
View article: Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study Open
View article: Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study
Clinical profiles of post‐load glucose subgroups and their association with glycaemic traits over time: An IMI‐DIRECT study Open
Aim To examine the hypothesis that, based on their glucose curves during a seven‐point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles at baseline and diff…
View article: Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity Open
Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-sc…
View article: Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study Open
View article: Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse
Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse Open
Background and Purpose Genetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA 1 ) receptor in fibrosis. We investigated the therapeutic potential in systemic sclerosis (SSc) of a new orally active select…
View article: Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts Open
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreve…
View article: Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study Open
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to th…
View article: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study Open
Aims/hypothesis It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) pr…
View article: Additional file 3 of Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Additional file 3 of Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study Open
Additional file 3. Supplementary Tables. This file contains Tables. S1 – S14.
View article: Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration Open
View article: Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium Open
View article: Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients
Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients Open