Explanipedia

Solitary Fibrous Tumor With Doege–Potter Syndrome Successfully Treated With Preoperative Transcatheter Arterial Embolization and Complete Excision; A Case Report Open

Rei Narimatsu, Ryuji Matsumoto, Haruka Miyata, Takahiro Osawa, Daisuke Abo , et al. · 2025

Introduction Doege–Potter syndrome (DPS) is a rare paraneoplastic phenomenon of severe hypoglycemia associated with solitary fibrous tumors (SFT). We report a case of a giant pelvic SFT with DPS, which was managed with preoperative arteria…

External validation of a motion capture-based surgical skill assessment system in laparoscopic simulation training environments Open

Koki Ebina, Takashige Abe, Kiyohiko Hotta, Yan Lingbo, Chihiro Kamijo , et al. · 2025

Our real-time feedback system was viewed favorably by the participants, and the ML algorithm was a reliable method, especially the predicted GOALS score. This system could facilitate objective performance assessment, enhance simulation-bas…

Establishment of potent TCR-T cells specific for cisplatin-resistance related tumor-associated antigen, CLSPN using codon-optimization Open

Kanta Hori, Shuhei Yamada, Kenji Murata, Haruka Miyata, Yuka Mizue , et al. · 2024

Adoptive T cell therapy, using T cell receptor-engineered T (TCR-T) cells and chimeric antigen receptor T (CAR-T) cells, is a potent immunotherapy option. Bladder cancer is a prevalent urological malignancy, particularly in cases of muscle…

Surgical skill analysis focused on tissue traction in laparoscopic wet lab training Open

Koki Ebina, Takashige Abe, Madoka Higuchi, Kiyohiko Hotta, Jun Furumido , et al. · 2024

The present results revealed experts' left-hand characteristics, including correct tissue grasping, sufficient tissue traction from the aorta, and stable traction angle. Our next challenge is the provision of immediate and visual feedback …

Validation and motion analyses of laparoscopic radical nephrectomy with Thiel-embalmed cadavers Open

Lingbo Yan, Koki Ebina, Takashige Abe, Masafumi Kon, Madoka Higuchi , et al. · 2024

Our aim was to develop practical training for laparoscopic surgery using Thielembalmed cadavers. Furthermore, in order to verbalize experts' motion characteristics and provide objective feedback to trainees, we initiated motion capture ana…

Enhancing the image quality of prostate diffusion-weighted imaging in patients with prostate cancer through model-based deep learning reconstruction Open

Noriko Nishioka, Noriyuki Fujima, Satonori Tsuneta, Masato Yoshikawa, Rina Kimura , et al. · 2024

A surgical instrument motion measurement system for skill evaluation in practical laparoscopic surgery training Open

Koki Ebina, Takashige Abe, Lingbo Yan, Kiyohiko Hotta, Toshiaki Shichinohe , et al. · 2024

This study developed and validated a surgical instrument motion measurement system for skill evaluation during practical laparoscopic surgery training. Owing to the various advantages of laparoscopic surgery including minimal invasiveness,…

Selective Transarterial Embolization for a Ruptured Persistent Trigeminal Artery Variant Aneurysm Open

Ryo Fujisawa, Yayoi YOSHIMURA, Hiroto Kawano, Keiichi Tsuji, Atsushi Tsuji , et al. · 2024

We report a male patient with a ruptured persistent primitive trigeminal artery variant aneurysm that resulted in a fistula with the cavernous sinus. He presented with left conjunctival hyperemia and exophthalmos. Cerebral angiography reve…

A prospective study of surgeons’ workloads and associated factors in real-world practice Open

Shigeru Harada, Takashige Abe, Jun Furumido, Keita Takahashi, Kanta Hori , et al. · 2024

New technologies such as laparoscopic and robotic surgery are spreading, and there is a demand for physicians to keep up with novel methods. In contrast to the recent focus on healthcare professional burnout, the mental and physical costs …

Cross-sectional and longitudinal analyses of urinary extracellular vesicle mRNA markers in urothelial bladder cancer patients Open

Taku Murakami, Keita Minami, Toru Harabayashi, Satoru Maruyama, Norikata Takada , et al. · 2024

We designed this multi-center prospective study with the following objectives: (1) the cross-sectional validation of extracellular vesicles (EV) mRNA markers to detect urothelial bladder cancer (UBC) before transurethral resection of bladd…

The impact of second transurethral resection on survival outcomes in patients with non-muscle-invasive bladder cancer treated with bacillus Calmette–Guérin therapy Open

Hiroshi Kikuchi, Takashige Abe, Makito Miyake, Haruka Miyata, Ryuji Matsumoto , et al. · 2023

Objective Several guidelines recommended that second transurethral resection should be performed in patients with diagnosis of high-risk non-muscle-invasive bladder cancer. However, therapeutic benefits of second transurethral resection be…

Impact of postoperative complications on long-term survival in bladder cancer patients Open

Takashige Abe, Shuhei Yamada, Hiroshi Kikuchi, Ataru Sazawa, Hidenori Katano , et al. · 2023

Objective To determine the impact of postoperative complications on long-term survival outcomes in patients with bladder cancer undergoing radical cystectomy. Methods This retrospective multi-institutional study included 766 bladder cancer…

Hemodynamic force as a potential regulator of inflammation-mediated focal growth of saccular aneurysms in a rat model Open

Kampei Shimizu, Hiroharu Kataoka, Hirohiko Imai, Yuto Yamamoto, Tomohiro Yamada , et al. · 2023

【背景】過去の研究より,脳動脈瘤増大機序において,マクロファージ依存的な慢性炎症が,重大な役割を果たしていることが明らかにされてきた.血行力学応力もまた,脳動脈瘤増大のトリガーであることが考えられてきたが,その機序は明らかにされていない.

A Case of Horizontal Stent-assisted Coiling for an Aneurysm Arising from Fenestration of the Vertebral Artery: A Technical Case Report Open

Haruka Miyata, Futa Ninomiya, Tomoaki Fujita, Yutaka Nonoyama, Takuya Nakazawa , et al. · 2023

Horizontal stenting protects the aneurysm neck with stent deployment across the aneurysm neck via the circle of Willis. A saccular aneurysm associated with intracranial arterial fenestration is very rare. Herein, we describe the first case…

Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma Open

Shuhei Yamada, Haruka Miyata, Makoto Isono, Kanta Hori, Junko Yanagawa , et al. · 2023

A Case of Neuroendocrine Carcinoid of the Middle Ear Presented with Spinal Metastasis Open

Haruka Miyata, Futa Ninomiya, Tomoaki Fujita, Yutaka Nonoyama, Takuya Nakazawa , et al. · 2023

Background : Carcinoids are neuroendocrine tumors that typically occur in the gastrointestinal and respiratory systems. Carcinoid tumors in the middle ear are rare. Herein, we report a case of middle ear carcinoid that developed spinal met…

Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma Open

Shuhei Yamada, Haruka Miyata, Makoto Isono, Kanta Hori, Junko Yanagawa , et al. · 2022

Bladder cancer is a major and fatal urological disease. Cisplatin is a key drug for the treatment of bladder cancer, especially in muscle-invasive cases. In most cases of bladder cancer, cisplatin is effective; however, resistance to cispl…

Comparative study of postoperative complications after radical cystectomy during the past two decades in Japan: Radical cystectomy remains associated with significant postoperative morbidities Open

Shuhei Yamada, Takashige Abe, Ataru Sazawa, Hidenori Katano, Hidetaka Suzuki , et al. · 2021

Surgical complications related to RC still remain significant problems, despite the recent improvements in surgical techniques and perioperative care. NAC did not increase the complications.

Efficacy of nivolumab plus ipilimumab as first-line therapy for primary tumors in patients with renal cell carcinoma Open

Hiroshi Kikuchi, Takahiro Osawa, Ryuji Matsumoto, Takashige Abe, Satoru Maruyama , et al. · 2021

Significant responses in primary tumors to nivolumab plus ipilimumab were observed in 50% of ccRCC patients, while responses varied among non-ccRCC patients. Inflammation markers may be predictive factors of treatment responses in primary …

GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy Open

Haruka Miyata, Yoshihiko Hirohashi, Shuhei Yamada, Junko Yanagawa, Aiko Murai , et al. · 2021

PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study Open

Kõji Tanaka, Shoji Matsumoto, Gulibahaer Ainiding, Ichiro NAKAHARA, Hidehisa Nishi , et al. · 2021

Background and purpose The impact of the paraoxonase-1 ( PON1 ) polymorphism, Q192R, on platelet inhibition in response to clopidogrel remains controversial. We aimed to investigate the association between carrier status of PON1 Q192R and …

Human tauopathy-derived tau strains determine the substrates recruited for templated amplification Open

Airi Tarutani, Haruka Miyata, Takashi Nonaka, Kazuko Hasegawa, Mari Yoshida , et al. · 2021

Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in Alzheimer’s disease, three-repeat tau in Pick’s disease (PiD) and four-repeat tau in pro…

Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model Open

Kampei Shimizu, Hiroharu Kataoka, Hirohiko Imai, Yuto Yamamoto, Tomohiro Yamada , et al. · 2020

Past studies have elucidated the crucial role of macrophage-mediated inflammation in the growth of intracranial aneurysms (IAs), but the contributions of hemodynamics are unclear. Considering the size of the arteries, we induced de novo an…

Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms in rats Open

Mika Kushamae, Haruka Miyata, Manabu Shirai, Kampei Shimizu, Mieko Oka , et al. · 2020

Subarachnoid hemorrhage due to rupture of an intracranial aneurysm has a quite poor prognosis after the onset of symptoms, despite the modern technical advances. Thus, the mechanisms underlying the rupture of lesions should be clarified. T…

Development and validation of a porcine organ model for training in essential laparoscopic surgical skills Open

Madoka Higuchi, Takashige Abe, Kiyohiko Hotta, Ken Morita, Haruka Miyata , et al. · 2020

Objectives To develop a wet laboratory training model for learning core laparoscopic surgical skills and evaluating learners’ competency level outside the operating room. Methods Participants completed three tasks (task 1: tissue dissectio…

The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial Aneurysm Open

Mieko Oka, Ono I, Kampei Shimizu, Mika Kushamae, Haruka Miyata , et al. · 2020

Considering the poor outcome of subarachnoid hemorrhage (SAH) due to the rupture of intracranial aneurysms (IA), mechanisms underlying the pathogenesis of IAs, especially the rupture of lesions, should be clarified. In the present study, a…

Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis Open

Mieko Oka, Satoshi Shimo, Nobuhiko Ohno, Hirohiko Imai, Yu Abekura , et al. · 2020

Smooth muscle cells (SMCs) are the major type of cells constituting arterial walls and play a role to maintain stiffness via producing extracellular matrix. Here, the loss and degenerative changes of SMCs become the major histopathological…

Erratum: Prognostic impact of local radiotherapy on metastatic urothelial carcinoma patients receiving systemic chemotherapy Open

Takashige Abe, Keita Minami, Toru Harabayashi, Ataru Sazawa, Hiroki Chiba , et al. · 2020

Erratum to: Outcome of maintenance systemic chemotherapy with drug-free interval for metastatic urothelial carcinoma Open

Takashige Abe, K Minami, Touru Harabayashi, A Sazawa, H Chiba , et al. · 2020

Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats Open

Yu Abekura, Ono I, Akitsugu Kawashima, Katsumi Takizawa, Hirokazu Koseki , et al. · 2020

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