Haruki Higashimori
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View article: Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism
Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autism Open
Summary To understand brain phenotypes associated with ASH1L, we performed both studies in mouse models and clinical phenotyping of human subjects. We found in mice that ASH1L mutations result in seizures, microcephaly, and also less compl…
View article: Functionally Clustered mRNAs Are Distinctly Enriched at Cortical Astroglial Processes and Are Preferentially Affected by FMRP Deficiency
Functionally Clustered mRNAs Are Distinctly Enriched at Cortical Astroglial Processes and Are Preferentially Affected by FMRP Deficiency Open
Mature protoplasmic astroglia in the mammalian CNS uniquely possess a large number of fine processes that have been considered primary sites to mediate astroglia to neuron synaptic signaling. However, localized mechanisms for regulating in…
View article: Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model
Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model Open
Fragile X syndrome (FXS) is one of the most common inherited intellectual disability (ID) disorders, in which the loss of FMRP protein induces a range of cellular signaling changes primarily through excess protein synthesis. Although neuro…
View article: Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB<sub>1</sub>R after stroke in rodents
Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB<sub>1</sub>R after stroke in rodents Open
Ischemia not only activates cell death pathways but also triggers endogenous protective mechanisms. However, it is largely unknown what is the essence of the endogenous neuroprotective mechanisms induced by preconditioning. In this study w…
View article: Molecular and Functional Properties of Regional Astrocytes in the Adult Brain
Molecular and Functional Properties of Regional Astrocytes in the Adult Brain Open
The molecular signature and functional properties of astroglial subtypes in the adult CNS remain largely undefined. By using translational ribosome affinity purification followed by RNA-Seq, we profiled astroglial ribosome-associated (pres…
View article: Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo
Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo Open
Previous studies to understand how the loss of function of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS) have largely focused on neurons; whether the selective loss of astroglial FMRP in vivo alters astrocyte …