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View article: Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis Open
Persistent neutrophil-dominated lung inflammation contributes to lung damage in cystic fibrosis (CF). However, the mechanisms that drive persistent lung neutrophilia and tissue deterioration in CF are not well characterized. Starting from …
View article: Human neutrophil development and functionality are enabled in a humanized mouse model
Human neutrophil development and functionality are enabled in a humanized mouse model Open
Mice with a functional human immune system serve as an invaluable tool to study the development and function of human immune system in vivo. A major technological limitation of all current humanized mouse models is the lack of mature and f…
View article: Recruited Monocytes/Macrophages Drive Pulmonary Neutrophilic Inflammation and Irreversible Lung Tissue Remodeling in Cystic Fibrosis
Recruited Monocytes/Macrophages Drive Pulmonary Neutrophilic Inflammation and Irreversible Lung Tissue Remodeling in Cystic Fibrosis Open
View article: 473: Impairing the recruitment of inflammatory monocytes to CF lungs does not weaken host defense against pulmonary Pseudomonas aeruginosa infections
473: Impairing the recruitment of inflammatory monocytes to CF lungs does not weaken host defense against pulmonary Pseudomonas aeruginosa infections Open
View article: 558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosis
558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosis Open
View article: Weak Agonistic LPS Restores Intestinal Immune Homeostasis
Weak Agonistic LPS Restores Intestinal Immune Homeostasis Open
View article: Visualization and quantification of <i>in vivo</i> homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer
Visualization and quantification of <i>in vivo</i> homing kinetics of myeloid-derived suppressor cells in primary and metastatic cancer Open
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells of the myeloid compartment and major players in the tumor microenvironment (TME). With increasing numbers of studies describing MDSC involvement in cancer immune escape, …
View article: Pseudomonas aeruginosa airway infection recruits and modulates myeloid-derived suppressor cells
Pseudomonas aeruginosa airway infection recruits and modulates myeloid-derived suppressor cells Open
Infektionen mit Pseudomonas (P.) aeruginosa, einem opportunistischen Bakterium, spielen eine wichtige Rolle für die Morbidität und Mortalität bei Mukoviszidose Patienten. Bei P. aeruginosa Infektionen wird das Immunsystem aktiviert, die Pa…
View article: CXCR1 Regulates Pulmonary Anti-<b><i>Pseudomonas</i></b> Host Defense
CXCR1 Regulates Pulmonary Anti-<b><i>Pseudomonas</i></b> Host Defense Open
Pseudomonas aeruginosa is a key opportunistic pathogen causing disease in cystic fibrosis (CF) and other lung diseases such as chronic obstructive pulmonary disease (COPD). However, the pulmonary host defense mechanisms regulating a…
View article: Supplementary Material for: CXCR1 Regulates Pulmonary Anti-<b><i>Pseudomonas</i></b> Host Defense
Supplementary Material for: CXCR1 Regulates Pulmonary Anti-<b><i>Pseudomonas</i></b> Host Defense Open
Pseudomonas aeruginosa is a key opportunistic pathogen causing disease in cystic fibrosis (CF) and other lung diseases such as chronic obstructive pulmonary disease (COPD). However, the pulmonary host defense mechanisms regulating a…
View article: A functional inflammasome activation assaydifferentiates patients with pathogenic NLRP3mutations and symptomatic patients with lowpenetrance variants
A functional inflammasome activation assaydifferentiates patients with pathogenic NLRP3mutations and symptomatic patients with lowpenetrance variants Open
QuestionThe cryopyrin-associated periodic syndromes (CAPS) are characterized by recurrent episodes of systemic inflammation.CAPS is caused by mutations in the NLRP3 gene encoding cryopyrin, an important component of the NLRP3 inflammasome …
View article: Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells
Pathogenic Fungi Regulate Immunity by Inducing Neutrophilic Myeloid-Derived Suppressor Cells Open