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View article: Curcumin Alleviates Doxorubicin-Induced Cardiotoxicity by Modulating Apelin Expression
Curcumin Alleviates Doxorubicin-Induced Cardiotoxicity by Modulating Apelin Expression Open
Background: Doxorubicin (Dox)-induced cardiotoxicity is the most important side effect of the drug and significantly limits its use in susceptible patients. Therefore, preventive measures are required to alleviate the Dox-induced cardiac f…
View article: Impact of catheter-to-vein diameter ratio on thrombosis in pediatric central venous catheterization
Impact of catheter-to-vein diameter ratio on thrombosis in pediatric central venous catheterization Open
Objective Catheter-related thrombosis is a common complication of central venous catheter insertion. As the use of central venous catheters increases in pediatric critical care settings, catheter-related thrombosis is becoming more common …
View article: Clinical and laboratory findings of patients with cystic fibrosis: a single center experience from Türkiye
Clinical and laboratory findings of patients with cystic fibrosis: a single center experience from Türkiye Open
Objective: The objective of this study was to evaluate the clinical characteristics of patients with cystic fibrosis (CF) and to determine whether there is a relationship between nutritional status and pulmonary functions. Additionally, th…
View article: Genetic Variants in Early-Onset Inflammatory Bowel Disease: Monogenic Causes and Clinical Implications
Genetic Variants in Early-Onset Inflammatory Bowel Disease: Monogenic Causes and Clinical Implications Open
Background/Objectives: This study aims to identify genetic variants associated with early-onset inflammatory bowel disease (IBD) and to improve diagnostic and therapeutic approaches. In selected monogenic IBD cases, treatment included colc…
View article: Impact of appetite stimulants on growth parameters in children with cystic fibrosis
Impact of appetite stimulants on growth parameters in children with cystic fibrosis Open
Objectives Malnutrition is prevalent among children with cystic fibrosis (CF),often resulting from frequent pulmonary exacerbations and intestinal malabsorption.In addition to providing sufficient calorie intake through enteral formulas, a…
View article: Where Should the Transition of Newborns Who are Technology Dependent and in Need of Support to Home Care in Turkey?
Where Should the Transition of Newborns Who are Technology Dependent and in Need of Support to Home Care in Turkey? Open
Introduction: The discharge rates of newborns dependent on medical technology and in need of palliative care have increased. Specialized care units aimed to reduce patient load in neonatal intensive care units (NICU), and increase the qual…
View article: Evaluation of nutritional status in pediatric intensive care unit patients: the results of a multicenter, prospective study in Turkey
Evaluation of nutritional status in pediatric intensive care unit patients: the results of a multicenter, prospective study in Turkey Open
Introduction Malnutrition is defined as a pathological condition arising from deficient or imbalanced intake of nutritional elements. Factors such as increasing metabolic demands during the disease course in the hospitalized patients and i…
View article: Glycogen storage diseases: An update
Glycogen storage diseases: An update Open
Glycogen storage diseases (GSDs), also referred to as glycogenoses, are inherited metabolic disorders of glycogen metabolism caused by deficiency of enzymes or transporters involved in the synthesis or degradation of glycogen leading to ab…
View article: Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis
Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis Open
Disrupted bile flow is a hallmark feature of patients with progressive familial intrahepatic cholestasis and can result in build-up of bile constituents in the liver with spill over into the bloodstream; other effects that patients can exp…
View article: The significance of MUAC z-scores in diagnosing pediatric malnutrition: A scoping review with special emphasis on neurologically disabled children
The significance of MUAC z-scores in diagnosing pediatric malnutrition: A scoping review with special emphasis on neurologically disabled children Open
This review by a panel of pediatric gastroenterology-hepatology-nutrition and pediatric neurology experts aimed to address the significance of mid-upper arm circumference (MUAC) assessment in diagnosis of pediatric malnutrition. Specifical…
View article: Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease
Magnetic resonance elastography in evaluation of liver fibrosis in children with chronic liver disease Open
Background Magnetic resonance elastography (MRE) has been used to stage liver fibrosis in adults. We aimed to assess the agreement between the Ishak scoring system and magnetic resonance elastography-measured liver stiffness (MRE-LS) in ch…
View article: TASL Practice Guidance on the Clinical Assessment and Management of Patients with Nonalcoholic Fatty Liver Disease
TASL Practice Guidance on the Clinical Assessment and Management of Patients with Nonalcoholic Fatty Liver Disease Open
Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevale…
View article: Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease
Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease Open
Background. Intestinal alkaline phosphatase (iAP) is an intestinal brush border enzyme that is one of the factors involved in the pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to investigate the relationship be…
View article: Is Prolonged Copper Restriction Needed in Pediatric Wilson’s Disease?
Is Prolonged Copper Restriction Needed in Pediatric Wilson’s Disease? Open
Daily copper consumption may be the least effective or non-effective factor on liver enzymes in Wilson's disease. Prolonged copper restriction may result in unintentional dietary imbalance. Avoidance of undernutrition and high-fat meals, a…
View article: Extracorporeal Therapies in Children with Acute Liver Failure: A Single-Center Experience
Extracorporeal Therapies in Children with Acute Liver Failure: A Single-Center Experience Open
Total plasma exchange and continuous renal replacement therapy are life-saving, and both methods may reduce morbidity and mortality, also bridging to liver transplantation.
View article: Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial Open
Albireo Pharma.
View article: Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey
Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey Open
Background Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care practice. However, …
View article: Endoscopic Retrograd Colangiopancreatography in Children: A Single Center Experience
Endoscopic Retrograd Colangiopancreatography in Children: A Single Center Experience Open
ÖzGiriş: Endoskopik retrograde kolanjiopankreatografi (ERCP) endoskopi ile fluoroskopiyi birlikte kullanan pankreas ve safra yolları hastalıklarında tanı ve tedavi imkanı sağlayan işlemdir
View article: An Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow’s Milk Protein Allergy
An Expert Panel Statement on the Beneficial Effects of Human Milk Oligosaccharides (HMOs) in Early Life and Potential Utility of HMO-Supplemented Infant Formula in Cow’s Milk Protein Allergy Open
This review by pediatric gastroenterology and allergy-immunology experts aimed to address the biological roles of human milk oligosaccharides (HMOs) and the potential utility of HMOs in prevention of allergy with particular emphasis on cow…
View article: A very rare cause of protein losing enteropathy: Gaucher disease
A very rare cause of protein losing enteropathy: Gaucher disease Open
Background. Mesenteric lymphadenopathy is a rare manifestation of Gaucher disease (GD) in children and can be accompanied by protein losing enteropathy (PLE). PLE is a difficult-to-treat complication of GD. To date, only a few pediatric GD…
View article: Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study
Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study Open
Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not have a high impact on inflammatory response and clinical outcome of the disease.
View article: Consensus Statement on Provision of Appropriate Nutritional Support in the Management of Childhood Malnutrition: A Turkey Perspective
Consensus Statement on Provision of Appropriate Nutritional Support in the Management of Childhood Malnutrition: A Turkey Perspective Open
This review by experts aimed to identify areas of consensus regarding the provision of appropriate nutritional support in the management of pediatric malnutrition that can be translated into a practical and implementable guidance document.…
View article: Brucellosis in a water buffalo (Bubalus bubalis) herd in Balikesir province of Turkey: a bacteriological and pathological investigation
Brucellosis in a water buffalo (Bubalus bubalis) herd in Balikesir province of Turkey: a bacteriological and pathological investigation Open
Brucellosis, caused by a facultative intracellular bacterium, induces great economic loss in the livestock economy worldwide. In this study, the abortion problem in an Anatolian water buffalo herd was investigated by pathological, bacterio…
View article: The HLA groups and their relationship with clinical features in Turkish children and adolescents with celiac disease
The HLA groups and their relationship with clinical features in Turkish children and adolescents with celiac disease Open
Background. We aimed to investigate the relationship between human leukocyte antigens (HLA)-groups and clinical features, and degree of intestinal injury in children with celiac disease (CD). Methods. Study group included 73 (50 females, 6…
View article: Distinctive Features of Hepatic Steatosis in Children: Is It Primary or Secondary to Inborn Errors of Metabolism?
Distinctive Features of Hepatic Steatosis in Children: Is It Primary or Secondary to Inborn Errors of Metabolism? Open
Parents with consanguinity and positive family history, together with clinical and biochemical findings, may provide a high index of suspicion for IEM to distinguish primary steatosis from the consequence of a more complex disorder.
View article: Challenges in management and prognosis of pediatric intestinal pseudo-obstruction
Challenges in management and prognosis of pediatric intestinal pseudo-obstruction Open
A total of 7 patients were included. The admission age was 3 days-10 years. The complaints were abdominal distention and constipation in all the patients. All the patients had passed meconium in the first 48 hours of their life. An upper g…
View article: Long term follow-up of children with chronic hepatitis B: a single center experience
Long term follow-up of children with chronic hepatitis B: a single center experience Open
Chronic Hepatitis B infection is an important clinical issue because of the associated risk of developing cirrhosis and hepatocellular carcinoma. Especially in children, there is no consensus about the optimal treatment. Clinical features …
View article: A necrobacillosis case determined in a sheep herd
A necrobacillosis case determined in a sheep herd Open
In this study, cases of necrobasillozis detected in a sheep herd in Kars province were described.A total of 12 deaths were noted in 2-4 month-old sheep in a herd containing 210 animals. Three of dead animals were brought to Kafkas Universi…