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View article: Protective Effects of Morin Against Paracetamol-Induced Nephrotoxicity via Modulation of Oxidative Stress, Inflammation, and Apoptosis Pathways
Protective Effects of Morin Against Paracetamol-Induced Nephrotoxicity via Modulation of Oxidative Stress, Inflammation, and Apoptosis Pathways Open
Objective: Paracetamol (PCM), although a widely used and non-prescription effective analgesic and antipyretic, can cause nephrotoxicity by causing kidney damage at high doses. Morin (MRN) is a flavonoid found in white mulberry and cranberr…
View article: Acute Neurochemical, Psychophysiological, and Cognitive Responses to Small-Sided Games vs. Running-Based HIIT in Young, Male Soccer Players
Acute Neurochemical, Psychophysiological, and Cognitive Responses to Small-Sided Games vs. Running-Based HIIT in Young, Male Soccer Players Open
Background: This study aimed to compare the immediate effects of small-sided games (SSGs) and running-based high-intensity interval training (HIITrb) on serum brain-derived neurotrophic factor (BDNF) levels, cognitive performance, and enjo…
View article: Carvacrol Coadministration Ameliorates Lambda‐Cyhalothrin‐Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence
Carvacrol Coadministration Ameliorates Lambda‐Cyhalothrin‐Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence Open
This study aimed to investigate the possible neuroprotective effects of Carvacrol (CRV) against Lambda‐cyhalothrin (CYH)‐induced peripheral neuropathy. Thirty‐five rats were divided into five groups: Control, CRV, CYH, CYH+CRV25, and CYH+C…
View article: Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways
Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways Open
Diclofenac (DF), a nonsteroidal and anti‐inflammatory drug, has limited use due to its adverse effects on the liver. On the other hand, morin, a bioflavonoid, has biological and pharmacological properties. This study aims to investigate wh…
View article: The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats
The Protective Effects of Chrysin on Acrylamide‐Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats Open
Acrylamide (ACR) is a toxic chemical with a high carcinogenic risk that is released as a result of heating or processing foods at high temperatures. Chrysin (CHR) is a flavonoid that is naturally found in foods such as honey and passionflo…
View article: Chrysin Counteracts Sodium Hydroxide-Induced Alkali Esophageal Burn by Regulating Beclin-1/HO-1/NQO1, PERK/IRE1-α/ATF-6, Oxidative Stress, Inflammation, Apoptosis Signaling Pathways and Ki-67, EGF Expressions in Rats
Chrysin Counteracts Sodium Hydroxide-Induced Alkali Esophageal Burn by Regulating Beclin-1/HO-1/NQO1, PERK/IRE1-α/ATF-6, Oxidative Stress, Inflammation, Apoptosis Signaling Pathways and Ki-67, EGF Expressions in Rats Open
Aim Alkali-esophageal burn due to ingestion of corrosive substances is an important clinical entity that can be seen in all age groups, especially children. Chrysin is a natural flavonoid compound with a wide range of biological activities…
View article: Potent Ameliorative Effects of Rosmarinic Acid on Tramadol-Induced Neurotoxicity in the Brain and Hippocampus; by Suppressing Oxidative stress, Apoptosis, ER stress, and Regulating Cognitive Functions
Potent Ameliorative Effects of Rosmarinic Acid on Tramadol-Induced Neurotoxicity in the Brain and Hippocampus; by Suppressing Oxidative stress, Apoptosis, ER stress, and Regulating Cognitive Functions Open
Tramadol (TRM) is a synthetic opioid analgesic that acts on the central nervous system and is used to treat moderate or severe pain. However, the incidence of its abuse is increasing. Rosmarinic acid (RA) is a natural flavonoid known for i…
View article: Investigation of the effects of chrysin on intestinal ischemia-reperfusion via apoptotic, oxidative stress, inflammation, and autophagy parameters
Investigation of the effects of chrysin on intestinal ischemia-reperfusion via apoptotic, oxidative stress, inflammation, and autophagy parameters Open
Aim: This study aimed to investigate chrysin's molecular, biochemical, and histological effects in an experimental intestinal ischemia/reperfusion (IR) model and to reveal possible protective mechanisms. Material-Methods: 35 Wistar rats we…
View article: Effects of Morin on the Wnt, Notch1/Hes1, KI-67/3-Nitrotyrosine and Damage Signaling Pathways in Rats Subjected to Experimental Testicular Ischemia/Reperfusion
Effects of Morin on the Wnt, Notch1/Hes1, KI-67/3-Nitrotyrosine and Damage Signaling Pathways in Rats Subjected to Experimental Testicular Ischemia/Reperfusion Open
Aim Testicular torsion, which occurs when the testicle rotates around the axis of the spermatic cord, is a serious cause of hospital admission, mostly in newborns and children, but also in adults. Oxidative stress is an important mediator …
View article: Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways.
Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways. Open
Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.
View article: Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf‐2/HO‐1/NQO1, Ki‐67 and Wnt Signaling Pathways
Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf‐2/HO‐1/NQO1, Ki‐67 and Wnt Signaling Pathways Open
Ovarian ischemia is a pathological condition that usually occurs due to ovarian torsion, resulting in the interruption of blood supply to the ovaries and oxygen deficiency. Silymarin (SLM) is a flavonoid complex of plant origin with pharma…
View article: Carvacrol Ameliorates Cisplatin-Induced Cardiotoxicity By Regulating Notch/Hes1 Signaling Pathway, Oxidative Stress and Cell Death In Rat Cardiac Tissue
Carvacrol Ameliorates Cisplatin-Induced Cardiotoxicity By Regulating Notch/Hes1 Signaling Pathway, Oxidative Stress and Cell Death In Rat Cardiac Tissue Open
Cisplatin is one of the most active cytotoxic agents used mainly in the treatment of solid tumors. High doses and long-term use of Cisplatin are known to cause cardiotoxicity. In recent years, the antiapoptotic and antioxidant effects of C…
View article: Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats
Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats Open
Aspirin is one of the most widely used non-steroidal anti-inflammatory drugs worldwide. Neurodegenerative diseases adversely affect the central nervous system, leading to cognitive decline. Aspirin has different pharmacological activities …
View article: The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways
The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways Open
Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body is the liver. Carvacrol is a natural phytocompound that stands out with its antioxidant, anti‐inflammatory, and antiapoptotic proper…
View article: Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways Open
Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and its antioxidant p…
View article: Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats
Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats Open
Hesperidin was able to decrease I/R injury of the stomach tissue due to inhibition of lipid peroxidation and protein oxidation, duration of antioxidant, and free radical scavenger properties. Consequently, hesperidin can provide a benefici…
View article: Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model
Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model Open
Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of biological and pharmacological activities, including antioxidant …
View article: High-Salt Diet Differentially Affects Anxiety-Depression-Like Behaviours and Cognitive Functions in Mice: Gender Difference
High-Salt Diet Differentially Affects Anxiety-Depression-Like Behaviours and Cognitive Functions in Mice: Gender Difference Open
Objective: Salt is a compound used for taste and flavor in the daily diet. Although the World Health Organization (WHO) recommends salt consumption below 5g/day, the average worldwide is 15.24g. A high salt diet (HSD) causes cognitive impa…
View article: Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach
Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach Open
Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel (PTX) is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin …
View article: Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage
Naringin Protects Against Colistin-Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage Open
Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many plants, especially…
View article: Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats
Antioxidant, Antiinflammatory, and Antiapoptotic Effects of Rutin in Spleen Toxicity Induced by Sodium Valproate in Rats Open
Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory and antiapoptotic eff…
View article: Effects of Quercetin on Cypermethrin-Induced Stomach Injury: The Role of Oxidative Stress, Inflammation, and Apoptosis.
Effects of Quercetin on Cypermethrin-Induced Stomach Injury: The Role of Oxidative Stress, Inflammation, and Apoptosis. Open
This study was conducted to investigate the effects of quercetin (QUE) on cypermethrin (CYP) induced gastrotoxicity in rats. 35 Sprague-Dawley rats were randomly divided into five groups, 7 in each group. In the study, 25 and 50 mg/kg QUE …
View article: The effect of smartphone addiction on attention level in high school students
The effect of smartphone addiction on attention level in high school students Open
Objective: Smartphones are electronic devices that have an important place in our lives today and provide many conveniences. However, it can cause many problems such as distraction and social isolation. The aim of this study is to investig…
View article: High Incidence of Appendiceal Neoplasms in the Elderly: A Critical Concern for Non-Surgical Treatment
High Incidence of Appendiceal Neoplasms in the Elderly: A Critical Concern for Non-Surgical Treatment Open
Objective: Appendiceal neoplasms (ANs) are rare tumors that are often discovered incidentally during histopathological examinations. The increasing incidence of ANs is a critical issue in the non-operative management of acute appendicitis.…
View article: Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.
Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach. Open
Evaluating all data showed that SA caused toxic damage to lung tissue by increasing inflammation, apoptosis, autophagy, and oxidant levels, whereas ZNG had a protective effect by reducing this damage.
View article: Comparison of Online Education and Face-to-face Education in terms of Student Satisfaction in Physiology Education
Comparison of Online Education and Face-to-face Education in terms of Student Satisfaction in Physiology Education Open
Aim: The coronavirus disease 2019 (COVID-19) has become a rapidly spreading pandemic all over the World. Social isolation is the most effective prevention option after vaccination. Many habits have changed in our lives due to social isolat…
View article: The Antinociceptive Effect of Adalimumab, a TNF-Alpha Inhibitor, in a Mice Model of Inflammatory Pain
The Antinociceptive Effect of Adalimumab, a TNF-Alpha Inhibitor, in a Mice Model of Inflammatory Pain Open
The aim of this study, evaluate the nociceptive effect of adalimumab, a TNF-alpha inhibitor, on formalin-induced inflammatory pain in mice. The antinociceptive activity of adalimumab was determined on adult male BALB-C mice (6 mice in each…