Hassaan Mehboob Awan
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View article: In silico analysis of point mutation (c.687dupC; p. Met230Hisfs∗6) in PGAM2 gene that causes Glycogen Storage Disease (GSD) Type X
In silico analysis of point mutation (c.687dupC; p. Met230Hisfs∗6) in PGAM2 gene that causes Glycogen Storage Disease (GSD) Type X Open
Glycogen storage disease (GSD) type X is an autosomal recessive disorder that affects skeletal muscles and is caused by PGAM-2 (Phosphoglycerate Mutase-2) enzyme deficiency. This deficiency is due to a mutation in the PGAM-2 gene at chromo…
View article: In silico analysis and experimental validation shows negative correlation between miR-1183 and cell cycle progression gene 1 expression in colorectal cancer
In silico analysis and experimental validation shows negative correlation between miR-1183 and cell cycle progression gene 1 expression in colorectal cancer Open
MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by binding to the 3’ untranslated regions (UTR) of target genes. Aberrant expression of miRNAs can lead to disease, including cancer. Colorect…
View article: Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease
Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease Open
Coronary heart disease (CHD) is a global health concern, and its molecular origin is not fully elucidated. Dysregulation of ncRNAs has been linked to many metabolic and infectious diseases. This study aimed to explore the role of circRNAs …
View article: Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression
Involvement of miR-3648 mediated APC2 1 dysregulation in early onset and breast cancer progression Open
Multiple cancers arise due to aberrations in the Wnt signaling pathway. Several miRNAs modulate the integral components of the wingless integrated (Wnt) signaling pathway. miR-3648 is a human-specific miRNAs that is of particular interest …
View article: Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression
Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression Open
microRNAs (miRNAs) are critical regulators of gene expression. For elucidating functional roles of miRNAs, it is critical to identify their direct targets. There are debates about whether pulldown of biotinylated miRNA mimics can be used t…
View article: Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation
Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation Open
MicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 …
View article: Primate-Specific Long Non-Coding RNAs and MicroRNAs
Primate-Specific Long Non-Coding RNAs and MicroRNAs Open
Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specifi…
View article: The DEAD-Box RNA Helicase DDX3 Interacts with m<sup>6</sup>A RNA Demethylase ALKBH5
The DEAD-Box RNA Helicase DDX3 Interacts with m<sup>6</sup>A RNA Demethylase ALKBH5 Open
DDX3 is a member of the family of DEAD-box RNA helicases. DDX3 is a multifaceted helicase and plays essential roles in key biological processes such as cell cycle, stress response, apoptosis, and RNA metabolism. In this study, we found tha…
View article: The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation
The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation Open
Significance We have developed a contrast screening strategy of systematic evolution of ligand exponential enrichment to isolate an RNA aptamer targeting specifically to p53R175H. This RNA aptamer partially rescued p53R175H in both cell cu…