Hassan Hashimi
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View article: The Core MICOS Complex Subunit mic60 has Been Substituted by Two Cryptic Mitofilin-containing Proteins in Euglenozoa
The Core MICOS Complex Subunit mic60 has Been Substituted by Two Cryptic Mitofilin-containing Proteins in Euglenozoa Open
Cristae enclose respiratory chain complexes, making them the bioenergetic subcompartments of mitochondria. The Mitochondrial contact site and Cristae Organizing System (MICOS) complex is among the inducers of membrane curvature needed for …
View article: The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa
The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa Open
Cristae enclose respiratory chain complexes, making them the bioenergetic subcompartments of mitochondria. The MICOS complex is among the inducers of membrane curvature needed for crista formation. Resembling the respiratory chain complexe…
View article: Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion
Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion Open
Mitochondria are dynamic and plastic, undergoing continuous fission and fusion and rearrangement of their bioenergetic sub‐compartments called cristae. These fascinating processes are best understood in animal and fungal models, which are …
View article: Trypanosomes as a magnifying glass for cell and molecular biology
Trypanosomes as a magnifying glass for cell and molecular biology Open
View article: A Novel Group of Dynamin-Related Proteins Shared by Eukaryotes and Giant Viruses Is Able to Remodel Mitochondria From Within the Matrix
A Novel Group of Dynamin-Related Proteins Shared by Eukaryotes and Giant Viruses Is Able to Remodel Mitochondria From Within the Matrix Open
The diverse GTPases of the dynamin superfamily play various roles in the cell, as exemplified by the dynamin-related proteins (DRPs) Mgm1 and Opa1, which remodel the mitochondrial inner membrane in fungi and metazoans, respectively. Via an…
View article: Intracytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60
Intracytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60 Open
View article: The development of intracytoplasmic membranes in alphaproteobacteria involves the conserved mitochondrial crista-developing protein Mic60
The development of intracytoplasmic membranes in alphaproteobacteria involves the conserved mitochondrial crista-developing protein Mic60 Open
Mitochondrial cristae expand the surface area of respiratory membranes and ultimately allow for the evolutionary scaling of respiration with cell volume across eukaryotes. The discovery of Mic60 homologs among alphaproteobacteria, the clos…
View article: Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae”
Erratum for Cadena et al., “Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae” Open
View article: Kinetoplastid-specific X2-family kinesins interact with a kinesin-like pleckstrin homology domain protein that localizes to the trypanosomal microtubule quartet
Kinetoplastid-specific X2-family kinesins interact with a kinesin-like pleckstrin homology domain protein that localizes to the trypanosomal microtubule quartet Open
Kinesins are motor proteins found in all eukaryotic lineages that move along microtubules to mediate cellular processes such as mitosis and intracellular transport. In trypanosomatids, the kinesin superfamily has undergone a prominent expa…
View article: A SURVEY OF CIVET CATS IN A SEMI-URBAN HABITAT IN TERENGGANU, MALAYSIA
A SURVEY OF CIVET CATS IN A SEMI-URBAN HABITAT IN TERENGGANU, MALAYSIA Open
View article: A SURVEY OF CIVET CATS IN A SEMI-URBAN HABITAT IN TERENGGANU, MALAYSIA
A SURVEY OF CIVET CATS IN A SEMI-URBAN HABITAT IN TERENGGANU, MALAYSIA Open
Malaysia is home to 11 civet cat species. However, there is not much information regarding these viverrids, especially in semi-urban areas. Thus, a survey of civet cats was conducted in Universiti Malaysia Terengganu (UMT), a semi-urban ar…
View article: Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae
Mitochondrial Contact Site and Cristae Organization System and F <sub>1</sub> F <sub>O</sub> -ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae Open
Mitochondria have undergone profound diversification in separate lineages that have radiated since the last common ancestor of eukaryotes some eons ago. Most eukaryotes are unicellular protists, including etiological agents of infectious d…
View article: MICOS and F<sub>1</sub>F<sub>O</sub>-ATP synthase crosstalk is a fundamental property of mitochondrial cristae
MICOS and F<sub>1</sub>F<sub>O</sub>-ATP synthase crosstalk is a fundamental property of mitochondrial cristae Open
Mitochondrial cristae are polymorphic invaginations of the inner membrane that are the fabric of cellular respiration. Both the Mitochondrial Contact Site and Cristae Organization System (MICOS) and the F O F 1 -ATP synthase are vital for …
View article: Ultrastructural Changes of the Mitochondrion During the Life Cycle of <i>Trypanosoma</i><i>brucei</i>
Ultrastructural Changes of the Mitochondrion During the Life Cycle of <i>Trypanosoma</i><i>brucei</i> Open
The mitochondrion is crucial for ATP generation by oxidative phosphorylation, among other processes. Cristae are invaginations of the mitochondrial inner membrane that house nearly all the macromolecular complexes that perform oxidative ph…
View article: Large-Scale Phylogenetic Analysis of Trypanosomatid Adenylate Cyclases Reveals Associations with Extracellular Lifestyle and Host–Pathogen Interplay
Large-Scale Phylogenetic Analysis of Trypanosomatid Adenylate Cyclases Reveals Associations with Extracellular Lifestyle and Host–Pathogen Interplay Open
Receptor adenylate cyclases (RACs) on the surface of trypanosomatids are important players in the host–parasite interface. They detect still unidentified environmental signals that affect the parasites’ responses to host immune challenge, …
View article: Returning to the Fold for Lessons in Mitochondrial Crista Diversity and Evolution
Returning to the Fold for Lessons in Mitochondrial Crista Diversity and Evolution Open
View article: A parasite’s take on the evolutionary cell biology of MICOS
A parasite’s take on the evolutionary cell biology of MICOS Open
View article: The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module
The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module Open
Summary The mitochondrial contact site and cristae organization system (MICOS) mediates the formation of cristae, invaginations in the mitochondrial inner membrane. The highly diverged MICOS complex of the parasitic protist Trypanosoma bru…
View article: PAR volume 146 issue 1 Cover and Back matter
PAR volume 146 issue 1 Cover and Back matter Open
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View article: The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import
The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import Open
View article: TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei
TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei Open
View article: Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution Open
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number of diseases in humans, domestic animals and plants. Their monoxe…
View article: Dynamin-like proteins in Trypanosoma brucei: A division of labour between two paralogs?
Dynamin-like proteins in Trypanosoma brucei: A division of labour between two paralogs? Open
Dynamins and dynamin-like proteins (DLPs) belong to a family of large GTPases involved in membrane remodelling events. These include both fusion and fission processes with different dynamin proteins often having a specialised function with…
View article: Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes
Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes Open
A dozen mRNAs are edited by multiple insertions and/or deletions of uridine residues in the mitochondrion of Trypanosoma brucei . Several protein complexes have been implicated in performing this type of RNA editing, including the mitochon…
View article: Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet
Trypanosome Mitochondrial Translation and Tetracycline: No Sweat about Tet Open
A recent study vividly demonstrates the unintended impact of the antibiotic tetracycline (Tet) on animal and plant mitochondrial translation, which corresponds to the α-proteobacterial origin of the organelle.This effect was ultimately man…
View article: Gene Loss and Error-Prone RNA Editing in the Mitochondrion of <i>Perkinsela</i> , an Endosymbiotic Kinetoplastid
Gene Loss and Error-Prone RNA Editing in the Mitochondrion of <i>Perkinsela</i> , an Endosymbiotic Kinetoplastid Open
Perkinsela is an enigmatic early-branching kinetoplastid protist that lives as an obligate endosymbiont inside Paramoeba (Amoebozoa). We have sequenced the highly reduced mitochondrial genome of Perkinsela , which possesses only six protei…
View article: Trypanosome <scp>RNA</scp> editing: the complexity of getting U in and taking U out
Trypanosome <span>RNA</span> editing: the complexity of getting U in and taking U out Open
RNA editing, which adds sequence information to RNAs post‐transcriptionally, is a widespread phenomenon throughout eukaryotes. The most complex form of this process is the uridine (U) insertion/deletion editing that occurs in the mitochond…
View article: Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing
Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing Open
Trypanosoma brucei is the causative agent of the human and veterinarian diseases African sleeping sickness and nagana. A majority of its mitochondrial-encoded transcripts undergo RNA editing, an essential process of post-transcriptional ur…