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View article: Cordyceps caterpillar polysaccharide CCP activates innate immune responses via the TLR4/MyD88/p38 signaling pathway
Cordyceps caterpillar polysaccharide CCP activates innate immune responses via the TLR4/MyD88/p38 signaling pathway Open
Background and Purpose Cordyceps is a widely used traditional Chinese medicine due to its many health benefits, such as immune regulation. As Cordyceps’ major component, polysaccharides are of great attention serving as a potential drug or…
View article: Oligosaccharide analysis of the backbone structure of the characteristic polysaccharide of Dendrobium officinale
Oligosaccharide analysis of the backbone structure of the characteristic polysaccharide of Dendrobium officinale Open
The backbone of Dendrobium officinale polysaccharide (DOP) was reported to be glucomannan. But the dispute continues due to the limitation of conventional analysis methods (e.g., the overlapped NMR signals). Herein, we describe an oligosac…
View article: M cells of mouse and human Peyer's patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycan
M cells of mouse and human Peyer's patches mediate the lymphatic absorption of an Astragalus hyperbranched heteroglycan Open
The gut cell wall is considered an impenetrable barrier to orally administrated polysaccharides. We recently reported a selective lymphatic route for Radix Astragali polysaccharide RAP to enter Peyer's patches (PPs) to trigger immune respo…
View article: Qualitative and Quantitative Analysis of Ejiao-Related Animal Gelatins through Peptide Markers Using LC-QTOF-MS/MS and Scheduled Multiple Reaction Monitoring (MRM) by LC-QQQ-MS/MS
Qualitative and Quantitative Analysis of Ejiao-Related Animal Gelatins through Peptide Markers Using LC-QTOF-MS/MS and Scheduled Multiple Reaction Monitoring (MRM) by LC-QQQ-MS/MS Open
Donkey-hide gelatin, also called Ejiao (colla corii asini), is commonly used as a food health supplement and valuable Chinese medicine. Its growing popular demand and short supply make it a target for fraud, and many other animal gelatins …
View article: A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing
A lymphatic route for a hyperbranched heteroglycan from Radix Astragali to trigger immune responses after oral dosing Open
Gut barrier makes a huge research gap between in vivo and in vitro studies of orally bioactive polysaccharides: whether/how they contact the related cells in vivo. A hyperbranched heteroglycan RAP from Radix Astragali, exerting antitumor a…
View article: Qualitative and Quantitative Analysis of Edible Bird’s Nest Based on Peptide Markers by LC-QTOF-MS/MS
Qualitative and Quantitative Analysis of Edible Bird’s Nest Based on Peptide Markers by LC-QTOF-MS/MS Open
Edible bird’s nest (EBN) is an expensive health food. There are many adulterants in the market. It remains challenging to discriminate EBN from its adulterants due to a lack of high-specificity markers. Besides, the current markers are con…
View article: Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties
Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties Open
View article: Anti-Fatigue Effects of the Unique Polysaccharide Marker of Dendrobium officinale on BALB/c Mice
Anti-Fatigue Effects of the Unique Polysaccharide Marker of Dendrobium officinale on BALB/c Mice Open
Dendrobium officinale extract shows potent anti-fatigue effects; however, the active substance responsible for these effects remains undetermined. A glucomannan with a huge molecular size of 730 kDa, called DOP, was identified as the uniqu…
View article: Comprehensive Quantitative Analysis of 32 Chemical Ingredients of a Chinese Patented Drug Sanhuang Tablet
Comprehensive Quantitative Analysis of 32 Chemical Ingredients of a Chinese Patented Drug Sanhuang Tablet Open
Sanhuang Tablet (SHT) is a Chinese patented drug commonly used for the treatment of inflammations of the respiratory tract, gastrointestinal tract, and skin. It contains a special medicinal composition including the single compound berberi…