Hauke Christian Tews
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View article: Decline in Serum Lysophosphatidylcholine Species in Patients with Severe Inflammatory Bowel Disease
Decline in Serum Lysophosphatidylcholine Species in Patients with Severe Inflammatory Bowel Disease Open
Background/Objectives: Lysophosphatidylcholine (LPC) is composed of various lipid species, some of which exert pro-inflammatory and others anti-inflammatory activities. However, most of the LPC species analyzed to date are reduced in the s…
View article: The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease
The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease Open
This study supports intestinal ultrasonography as a promising tool for assessing bowel damage in Crohn's disease, providing an alternative to magnetic resonance imaging/computed tomography and colonoscopy. Implementing intestinal ultrasono…
View article: Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis
Elevated long-to-very-long-chain ceramide ratio correlates with disease severity in inflammatory bowel disease and primary sclerosing cholangitis Open
View article: Galectin-3—Insights from Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
Galectin-3—Insights from Inflammatory Bowel Disease and Primary Sclerosing Cholangitis Open
Inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) are related diseases with poorly understood pathophysiology. While therapy options for IBD have increased, treatment options for PSC remain limited. Galectin-3 is a …
View article: Fecal Arachidonic Acid: A Potential Biomarker for Inflammatory Bowel Disease Severity
Fecal Arachidonic Acid: A Potential Biomarker for Inflammatory Bowel Disease Severity Open
Arachidonic acid levels are elevated in the colonic mucosa of patients with inflammatory bowel disease (IBD). Fecal metabolites are emerging as valuable diagnostic tools for IBD. This study aimed to investigate associations between 31 feca…
View article: Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease
Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease Open
Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown. To unravel th…
View article: Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease
Cholesteryl Ester Species but Not Serum Proprotein Convertase Subtilisin/Kexin Type 9 Levels Decline in Male Patients with Active Inflammatory Bowel Disease Open
Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum cholesterol levels and inflammation, both of which are dysregulated in inflammatory bowel disease (IBD). Free cholesterol (FC) and the various typ…
View article: Interprofessional approach to personalized medication management and therapy optimization in IBD care
Interprofessional approach to personalized medication management and therapy optimization in IBD care Open
A considerable number of patients with chronic inflammatory bowel diseases (IBD) are required to manage extensive polypharmaceutical regimes, which significantly elevates the risk of drug–drug interactions. Also, the disease’s impact often…
View article: Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease
Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease Open
Background/Objectives: Inflammatory bowel disease (IBD) is a chronic immune-mediated pathology associated with the dysregulation of lipid metabolism. The administration of nervonic acid, a very long-chain fatty acid, has been shown to impr…
View article: Paraptosis—A Distinct Pathway to Cell Death
Paraptosis—A Distinct Pathway to Cell Death Open
Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell death have been identified, each defined by unique molecular pathways. Understandi…
View article: Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis
Unique sterol metabolite shifts in inflammatory bowel disease and primary sclerosing cholangitis Open
Inflammatory bowel disease (IBD) triggers chronic intestinal inflammation and is linked to primary sclerosing cholangitis (PSC). Cholesterol homeostasis, tightly regulated under normal conditions, becomes disrupted in both inflammation and…
View article: Muskelschmerzen bei Myositis bei einer jungen Patientin – was steckt dahinter?
Muskelschmerzen bei Myositis bei einer jungen Patientin – was steckt dahinter? Open
Zusammenfassung Die Myositis ist eine Erkrankung aus dem Formenkreis der Kollagenosen, die am häufigsten bei Frauen zwischen dem 40. und 60. Lebensjahr auftritt. Bei einer deutlichen Assoziation mit malignen Grunderkrankungen wird bei der …
View article: High-resolution Visualization of Intestinal Microcirculation using Ultra-microangiography in Patients with Inflammatory Bowel Disease: A Pilot Study
High-resolution Visualization of Intestinal Microcirculation using Ultra-microangiography in Patients with Inflammatory Bowel Disease: A Pilot Study Open
Background and Aims: Ultra-microangiography (UMA) is a novel Doppler technique with optimized wall filtering that provides high sensitivity to low-velocity blood flows and optimized visualization of microcirculation. The aim of this pilot …
View article: Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease
Urinary Hydroxyproline as an Inflammation-Independent Biomarker of Inflammatory Bowel Disease Open
Predicting responses and monitoring the severity of inflammatory bowel disease (IBD) is challenging due to a lack of specific biomarkers. This study identifies urinary hydroxyproline, a marker of collagen turnover elevated in experimental …
View article: Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn’s disease severity
Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn’s disease severity Open
View article: Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis Open
Intoduction Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification. Methods Nuclear ma…
View article: Fistulising skin metastases in Crohn’s disease: a case report and review of the literature
Fistulising skin metastases in Crohn’s disease: a case report and review of the literature Open
Background Metastatic Crohn’s disease is a rare disorder characterized by various granulomatous skin lesions that occur independently of gastrointestinal tract involvement. However, currently there is no standardized care or specific treat…
View article: Urinary soluble CD163 is a putative non-invasive biomarker for primary sclerosing cholangitis
Urinary soluble CD163 is a putative non-invasive biomarker for primary sclerosing cholangitis Open
Soluble CD163 (sCD163) is a selective marker of macrophages whose circulating levels have been found to be induced in patients with active inflammatory bowel disease (IBD). Urinary proteins are emerging as non-invasive diagnostic biomarker…
View article: Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis
Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis Open
Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and…
View article: Health Implications of Lipedema: Analysis of Patient Questionnaires and Population-Based Matched Controls
Health Implications of Lipedema: Analysis of Patient Questionnaires and Population-Based Matched Controls Open
We conducted a comparative study involving 39 female patients with lipedema and group-matched controls at a ratio of 1:5. The primary survey tool was the German Health Update (GEDA 2019/2020-EHIS) questionnaire, which was developed by the …
View article: P1027 Optimizing IBD Medication and Therapy: An Interdisciplinary University Outpatient Approach
P1027 Optimizing IBD Medication and Therapy: An Interdisciplinary University Outpatient Approach Open
Background A large proportion of patients with chronic inflammatory bowel disease (IBD) take a wide range of different medications, which harbor a potential risk of pharmaceutical (pharm.) interactions. Furthermore, these patients frequent…
View article: P369 Altered fecal bile acid composition in active Ulcerative Colitis
P369 Altered fecal bile acid composition in active Ulcerative Colitis Open
Background A consistent finding in inflammatory bowel disease (IBD) is an altered composition of fecal bile acids, with an increase in primary bile acids and a decrease in secondary bile acids. It is less clear, whether fecal bile acids co…
View article: P327 Profiling serum metabolome and lipidome to differentiate primary sclerosing cholangitis from Inflammatory Bowel Disease and healthy controls
P327 Profiling serum metabolome and lipidome to differentiate primary sclerosing cholangitis from Inflammatory Bowel Disease and healthy controls Open
Background Currently, the diagnosis of primary sclerosing cholangitis (PSC) is challenging due to a lack of specific biomarkers. Identification of a distinct metabolome and lipidome profile of PSC patients is crucial to facilitate diagnosi…
View article: Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn’s Disease and Ulcerative Colitis Compared With Healthy Control Individuals
Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn’s Disease and Ulcerative Colitis Compared With Healthy Control Individuals Open
Background Accurate biomarkers for disease activity and progression in patients with inflammatory bowel disease (IBD) are a prerequisite for individual disease characterization and personalized therapy. We show that metabolic profiling of …
View article: Serum Metabolomic Profiling of Patients with Lipedema
Serum Metabolomic Profiling of Patients with Lipedema Open
Lipedema is a chronic condition characterized by disproportionate and symmetrical enlargement of adipose tissue, predominantly affecting the lower limbs of women. This study investigated the use of metabolomics in lipedema research, with t…
View article: Altered fecal bile acid composition in active ulcerative colitis
Altered fecal bile acid composition in active ulcerative colitis Open
View article: Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity
Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity Open
View article: Prospective study of computer-aided detection of colorectal adenomas in hospitalized patients
Prospective study of computer-aided detection of colorectal adenomas in hospitalized patients Open
Adenoma detection with polypectomy during total colonoscopy reduces the incidence of colorectal cancer (CRC) and colorectal cancer-associated mortality. The adenoma detection rate (ADR) is an established quality indicator, which is associa…
View article: Fecal and Urinary Adipokines as Disease Biomarkers
Fecal and Urinary Adipokines as Disease Biomarkers Open
The use of biomarkers is of great clinical value for the diagnosis and prognosis of disease and the assessment of treatment efficacy. In this context, adipokines secreted from adipose tissue are of interest, as their elevated circulating l…
View article: Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose Open