Haw Yang
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View article: Development of Poly(<i>p</i>-phenylene vinylene)-Derived Near-inFrared Two-Photon Fluorescent Dyes and Nucleus-Specific Fluorescent Probes
Development of Poly(<i>p</i>-phenylene vinylene)-Derived Near-inFrared Two-Photon Fluorescent Dyes and Nucleus-Specific Fluorescent Probes Open
PPV, an early air-stable conjugated polymer, is widely used in organic electronics and bioimaging due to its simple structure and UV-Vis spectral properties. This chapter explores the design, synthesis, and potential applications of near-i…
View article: 143P Efficacy and safety of aumolertinib (AUM) with radiotherapy versus concurrent chemoradiotherapy (cCRT) in the treatment of unresectable stage III EGFR-mutant NSCLC: A multicenter, randomized, open-label phase III study (ADVANCE)
143P Efficacy and safety of aumolertinib (AUM) with radiotherapy versus concurrent chemoradiotherapy (cCRT) in the treatment of unresectable stage III EGFR-mutant NSCLC: A multicenter, randomized, open-label phase III study (ADVANCE) Open
The PACIFIC subgroup analysis indicates that immune consolidation therapy may not be beneficial for patients (pts) harboring EGFR mutations. Our prior large retrospective multicenter study showed that combining radiotherapy with targeted t…
View article: Mechanical codes of chemical-scale specificity in DNA motifs
Mechanical codes of chemical-scale specificity in DNA motifs Open
Could genomic DNA have sequence specificity in its chemical-scale mechanical properties? We approach this question using statistical machine learning to determine the rigidity between DNA chemical moieties.
View article: Time-Resolved 3D Multi-Resolution Microscopy for Real-Time Cellulase Actions in Situ (Final Scientific/Technical Report)
Time-Resolved 3D Multi-Resolution Microscopy for Real-Time Cellulase Actions in Situ (Final Scientific/Technical Report) Open
In this Final Report, we are pleased to report that all technical innovation goals as described in the original grant proposal have been achieved. We also provide yet to be published results highlighting the new capabilities enabled by thi…
View article: The trajectory patterns of single HIV-1 virus-like particle in live CD4 cells: A real time three-dimensional multi-resolution microscopy study using encapsulated nonblinking giant quantum dot
The trajectory patterns of single HIV-1 virus-like particle in live CD4 cells: A real time three-dimensional multi-resolution microscopy study using encapsulated nonblinking giant quantum dot Open
A complete trajectory of HIV-1 VLP interacting with CD4 cells was presented in animation. This encapsulating method could increase the accuracy for the observation of HIV-1-CD4 cell interaction in real time and three dimensions.
View article: Multicolor Multifocal 3D Microscopy Using In-situ Optimization of A Spatial Light Modulator
Multicolor Multifocal 3D Microscopy Using In-situ Optimization of A Spatial Light Modulator Open
Multifocal microscopy enables high speed three-dimensional (3D) volume imaging by using a multifocal grating in the emission path. This grating is typically designed to afford a uniform illumination of multifocal subimages for a single emi…
View article: Structure-mechanics statistical learning uncovers mechanical relay in proteins
Structure-mechanics statistical learning uncovers mechanical relay in proteins Open
Protein residues exhibit specific routes of mechanical relay as the adaptive responses to substrate binding or dissociation. On such physically contiguous connections, residues experience prominent changes in their coupling strengths.
View article: Leveraging lifetime information to perform real-time 3D single-particle tracking in noisy environments
Leveraging lifetime information to perform real-time 3D single-particle tracking in noisy environments Open
A microscopy platform that leverages the arrival time of individual photons to enable 3D single-particle tracking of fast-moving (translational diffusion coefficient of ≃3.3 µm2/s) particles in high-background environments is reported here…
View article: Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases
Intermediary conformations linked to the directionality of the aminoacylation pathway of nonribosomal peptide synthetases Open
In-solution analysis of conformational changes of NRPS adenylation and peptidyl-carrier protein domains under catalytic conditions reveals a new intermediary conformation.
View article: Localization precision in chromatic multifocal imaging
Localization precision in chromatic multifocal imaging Open
Multifocal microscopy affords fast acquisition of microscopic 3D images. This is made possible using a multifocal grating optic, however this induces chromatic dispersion effects into the point spread function impacting image quality and s…
View article: Three-dimensional super line-localization in low signal-to-noise microscope images via prior-apprised unsupervised learning (PAUL)
Three-dimensional super line-localization in low signal-to-noise microscope images via prior-apprised unsupervised learning (PAUL) Open
Biological processes such as processive enzyme turnover and intracellular cargo tracking involve the dynamic motion of a small "article" along a curvilinear biopolymer track. To understand these processes that occur across multiple length …
View article: Uniform intensity in multifocal microscopy using a spatial light modulator
Uniform intensity in multifocal microscopy using a spatial light modulator Open
Multifocal microscopy (MFM) offers high-speed three-dimensional imaging through the simultaneous image capture from multiple focal planes. Conventional MFM systems use a fabricated grating in the emission path for a single emission wavelen…
View article: Structure-mechanics statistical learning unravels the linkage between local rigidity and global flexibility in nucleic acids
Structure-mechanics statistical learning unravels the linkage between local rigidity and global flexibility in nucleic acids Open
The mechanical properties of nucleic acids underlie biological processes ranging from genome packaging to gene expression. We devise structural mechanics statistical learning method to reveal their molecular origin in terms of chemical int…
View article: Photobleaching statistics in single-molecule on-/off-time distributions
Photobleaching statistics in single-molecule on-/off-time distributions Open
The on- and and off-time distributions from fluorescence single-molecule experiments are widely used to extract kinetics parameters with the goal to provide a quantitative description for the molecule’s behavior on the ensemble level. Such…
View article: Statistical Learning of Discrete States in Time Series
Statistical Learning of Discrete States in Time Series Open
Time series obtained from time-dependent experiments contain rich information of kinetics and dynamics of the system under investigation. This work describes an unsupervised learning framework, along with the derivation of the necessary an…
View article: Nano-plasmonics and electronics co-integration in CMOS enabling a pill-sized multiplexed fluorescence microarray system
Nano-plasmonics and electronics co-integration in CMOS enabling a pill-sized multiplexed fluorescence microarray system Open
The ultra-miniaturization of massively multiplexed fluorescence-based bio-molecular sensing systems for proteins and nucleic acids into a chip-scale form, small enough to fit inside a pill (∼ 0.1cm3), can revolutionize sensing modalities i…
View article: Discovery of Protein- and DNA-Imperceptible Nanoparticle Hard Coating Using Gel-Based Reaction Tuning
Discovery of Protein- and DNA-Imperceptible Nanoparticle Hard Coating Using Gel-Based Reaction Tuning Open
The seemingly inevitable protein corona appears to be an insurmountable obstacle to wider application of functional nanomaterials in biotechnology. The accumulation of serum proteins can block targeting functionalities and alter the in viv…
View article: Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy
Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy Open
The overwhelming effort in the development of new microscopy methods has been focused on increasing the spatial and temporal resolution in all three dimensions to enable the measurement of the molecular scale phenomena at the heart of biol…