Hayam E. Rashed
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View article: Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas
Correlation between Isocitrate Dehydrogenase Mutation and Immunohistochemical Expression of DNA Mismatch Repair Proteins in the Prognosis of Gliomas Open
IDH1 mutation and MMR proteins (MLH1, MSH6, and MSH2) could help predict glioma outcome.
View article: Chronic Diarrhea Owing to Microscopic Colitis: A Cohort Study with Insights into Diagnostic Challenges and Size of the Problem
Chronic Diarrhea Owing to Microscopic Colitis: A Cohort Study with Insights into Diagnostic Challenges and Size of the Problem Open
Background: Microscopic colitis (MC) is a recognized cause of chronic diarrhea and is often underestimated when a colonoscopy appears normal. This study aims to accurately diagnose chronic diarrhea through histopathological examination of …
View article: Human protozoa infection and dysplasia in ulcerative colitis: a neglected aspect in a prominent disease
Human protozoa infection and dysplasia in ulcerative colitis: a neglected aspect in a prominent disease Open
View article: Outcome of docetaxel in treatment of metastatic hormone-sensitive prostate cancer and correlation with hemoglobin, albumin, lymphocyte and platelets score
Outcome of docetaxel in treatment of metastatic hormone-sensitive prostate cancer and correlation with hemoglobin, albumin, lymphocyte and platelets score Open
Our results confirmed the benefits of treatment with docetaxel plus ADT in high-burden mHSPC with accepted tolerance. HALP score was found to be an independent predictive factor for benefit from therapy; we can apply it as an easy way to s…
View article: A Promising Diagnostic Role of Immunohistochemical Expression of Insulin-Like Growth Factor II mRNA Binding Protein3 (IMP3) in Pancreatic Lesions Using Endoscopic Ultrasound –Guided –Fine Needle Aspiration (EUS-FNA) Cytology
A Promising Diagnostic Role of Immunohistochemical Expression of Insulin-Like Growth Factor II mRNA Binding Protein3 (IMP3) in Pancreatic Lesions Using Endoscopic Ultrasound –Guided –Fine Needle Aspiration (EUS-FNA) Cytology Open
Background: Poor prognosis and short survival of patients harboring pancreatic cancer emerge how advanced disease it is. In a trial to achieve the earliest and most accurate diagnosis to manage this progressive disease, we proposed that us…
View article: Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis
Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis Open
View article: Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: Correlation between Androgen Receptor Expression and Pathological Response
Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: Correlation between Androgen Receptor Expression and Pathological Response Open
Our results suggested that the AR expression in TNBC may be applied as a predictive marker for NAC. TNBC AR+ had a lower rate of pCR compared with QNBC, suggesting that this subtype may have a partial chemoresistance.
View article: EFFECT OF CINNAMON AND GINGER METHANOLIC EXTRACTS ON MURINE INTESTINAL CRYPTOSPORIDIOSIS.IN-VIVO EVALUATION
EFFECT OF CINNAMON AND GINGER METHANOLIC EXTRACTS ON MURINE INTESTINAL CRYPTOSPORIDIOSIS.IN-VIVO EVALUATION Open
Cryptosporidium species the Apicomplexa protozoan parasites, causing diarrheal disease in man and animals, due to the lack of a licensed vaccine and resistance to the available effective therapy.This study explored the curative and the pro…
View article: Immunohistochemical expression of programmed death-ligand 1 (PD-L1) in invasive duct carcinoma of the breast of no special type and correlation with patients' clinicopathological parameters
Immunohistochemical expression of programmed death-ligand 1 (PD-L1) in invasive duct carcinoma of the breast of no special type and correlation with patients' clinicopathological parameters Open
Background: Breast cancer is still the most significant cancer-causing mortality among females around the world.Invasive duct carcinoma of no special type is the most prevalent type of breast cancer.So it is essential to search for novel a…
View article: CARVEDILOL AND NEBIVOLOL PROTECT THE KIDNEY AGAINST RENAL ISCHEMIA IN WISTAR RATS.
CARVEDILOL AND NEBIVOLOL PROTECT THE KIDNEY AGAINST RENAL ISCHEMIA IN WISTAR RATS. Open
Background: Classical β-blockers usually reduce renal blood flow thus, worsening renal function in hypertensive patients with renal impairment.However, vasodilator -blockers with biased agonist activity on -arrestin, at least theoretical…
View article: C-MYC and BCL2: Correlation between Protein Over-Expression and Gene Translocation and Impact on Outcome in Diffuse Large B Cell Lymphoma
C-MYC and BCL2: Correlation between Protein Over-Expression and Gene Translocation and Impact on Outcome in Diffuse Large B Cell Lymphoma Open
Background: Due to lack of availability of gene expression profiling (GEP) for most developing countries and clinicians; the immunohistochemistry (IHC) is mostly used in the clinical application. The aim of our study is to check the possib…
View article: ARTESUNATE LOADED NANOFIBER AND ITS COMBINATIONS WITH SPIRAMYCIN FOR TREATMENT OF MURINE TOXOPLASMOSIS
ARTESUNATE LOADED NANOFIBER AND ITS COMBINATIONS WITH SPIRAMYCIN FOR TREATMENT OF MURINE TOXOPLASMOSIS Open
Although toxoplasmosis is worldwide spread, the available medications have low efficacy and high toxicity.This research aims to study the effect of artesunate loaded nanofiber and its combination with spiramycin as an alternative treatment…
View article: The Hazards of Tramadol on the Liver Structure of Adult Male Albino Rats and the Possible Protective Role of N-acetylcysteine: Histological and Immunohistochemical Study
The Hazards of Tramadol on the Liver Structure of Adult Male Albino Rats and the Possible Protective Role of N-acetylcysteine: Histological and Immunohistochemical Study Open
Background: Tramadol administration is associated with hepatic congestion, apoptosis and induces oxidative damage in tissues.The thiol group in N-acetyl-cysteine (NAC) interacts directly with reactive oxygen species leading to cellular pro…
View article: The New Trend in the Treatment of Experimental Cryptosporidiosis and the Resulting Intestinal Dysplasia
The New Trend in the Treatment of Experimental Cryptosporidiosis and the Resulting Intestinal Dysplasia Open
Aim: Cryptosporidiosis causes colon dysplasia. This research aimed to evaluate the effect of a novel combination between artesunate and nitazoxanide on intensity of infection and the resulting intestinal dysplasia. Materials & methods: Sub…
View article: Prediction of Helicobacter Pylori Clarithromycin Resistance by Detection of Point Mutations in 23S rRNA gene
Prediction of Helicobacter Pylori Clarithromycin Resistance by Detection of Point Mutations in 23S rRNA gene Open
Background: Clarithromycin is one of the most common drugs recommended as firstline eradication therapy for H. pylori infection but the prevalence of clarithromycin resistant H. pylori is increasing.Clarithromycin-resistance is associated …
View article: The relationship between toxoplasmosis and different types of human tumors
The relationship between toxoplasmosis and different types of human tumors Open
Introduction: Toxoplasma gondii is an intracellular protozoan that may disrupt the traditional cell barriers against cancer, allowing the accumulation of oncogenic mutations over time. Our research aimed to explore the relationship between…
View article: Window-of-opportunity Study Testing the Antiproliferative Effect of Atorvastatin in Egyptian Patients with Operable Breast Cancer
Window-of-opportunity Study Testing the Antiproliferative Effect of Atorvastatin in Egyptian Patients with Operable Breast Cancer Open
Backgroundand purpose: Cholesterol-lowering drugs (statins) appear to have pleiotropic effects independent of cholesterol level.The aim of this study was to assess the effect of pre-operative therapy with a statin (atorvastatin) on tumor p…
View article: Prognostic significance of programmed cell death ligand 1 (PD-L1), CD8+ tumour-infiltrating lymphocytes, and P53 in non-small cell lung cancer: An immunohistochemical study
Prognostic significance of programmed cell death ligand 1 (PD-L1), CD8+ tumour-infiltrating lymphocytes, and P53 in non-small cell lung cancer: An immunohistochemical study Open
View article: HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES IN EXPERIMENTAL HETEROPHYIASIS AND THE ROLE OF PRAZIQUANTEL AND AMINOGUANIDINE
HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDIES IN EXPERIMENTAL HETEROPHYIASIS AND THE ROLE OF PRAZIQUANTEL AND AMINOGUANIDINE Open
Histopathological diagnosis was used to understand the pathological events associated with Heterophyes heterophyes (H. heterophyes) infection. CD3 and CD79α antibodies had been used as markers for both T and. B lymphocytes respectively. Im…
View article: Prognostic significance of programmed cell death ligand 1 (pd-l1), cd8+ tumor-infiltrating lymphocytes and p53 in non-small cell lung cancer: an immunohistochemical study
Prognostic significance of programmed cell death ligand 1 (pd-l1), cd8+ tumor-infiltrating lymphocytes and p53 in non-small cell lung cancer: an immunohistochemical study Open
PD-L1 overexpression is an unfavorable prognostic marker, while the high CD8 + TILs is a good prognostic marker in non-small cell lung cancer. PD-L1 immunohistochemical assessment may be used for the selection of patients legible for treat…
View article: Evaluation of the role of captopril on clozapine-induced cardiotoxicity and hematotoxicity in adult male albino rats
Evaluation of the role of captopril on clozapine-induced cardiotoxicity and hematotoxicity in adult male albino rats Open
Clozapine (CLZ) is considered the most effective drug in treatment of resistant schizophrenia. However, its cardiotoxic effect has raised concerns about its safety. Captopril is a well-known angiotensin-converting enzyme inhibitor with uni…
View article: IMMUNOGENICITY ASSESSMENT FOR LUNG-STAGE AND BIOMPHALARIA ALEXANDRINA COCKTAIL VACCINE IN SCHISTOSOMA MANSONI INFECTED MICE
IMMUNOGENICITY ASSESSMENT FOR LUNG-STAGE AND BIOMPHALARIA ALEXANDRINA COCKTAIL VACCINE IN SCHISTOSOMA MANSONI INFECTED MICE Open
Six groups of Swiss albino mice were used; (Gl) as a control, (G2) infected non immunized; (G3) infected and supported by Adj.; (G4) infected; vaccinated with BAAP and supported by Adj.; (G5) infected, vaccinated with SLAP and supported by…
View article: Prognostic value of aldh1, ezh2 and ki-67 in astrocytic gliomas
Prognostic value of aldh1, ezh2 and ki-67 in astrocytic gliomas Open
Increased expression of ALDH1, EZH2 and KI67 are found to be associated with unfavourable prognosis in patients with astrocytic gliomas and may predict therapeutic modalities.