Hayley C. Affronti
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View article: Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Open
View article: A feedforward loop between ACLY and MYC supports T-ALL progression in vivo
A feedforward loop between ACLY and MYC supports T-ALL progression in vivo Open
View article: ACLY alternative splicing correlates with cancer phenotypes
ACLY alternative splicing correlates with cancer phenotypes Open
View article: Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis Open
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are pro…
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Supplementary Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis Open
Figures S1-S7 and Table S1
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis Open
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Data from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Data from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification o…
View article: Supplementary Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Supplementary Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis Open
Figures S1-S7 and Table S1
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Data from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Data from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Identifying and leveraging unique points of metabolic dysregulation in different disease settings is vital for safe and effective incorporation of metabolism-targeted therapies in the clinic. In addition, it has been shown identification o…
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Table from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy Open
Supplementary Figure from JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy
View article: Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
Data from Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis Open
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed. We previously reported that histone H4 acetylation is elevated in pancreatic acinar cells harboring Kras