Haytham Mohamed Aly Mohamed
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View article: Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line
Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line Open
View article: CNOT1 regulates circadian behaviour through <i>Per2</i> mRNA decay in a deadenylation-dependent manner
CNOT1 regulates circadian behaviour through <i>Per2</i> mRNA decay in a deadenylation-dependent manner Open
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology. It has been recently shown that post-transcriptional mech…
View article: CNOT1 regulates circadian behaviour through <i>Per2</i> mRNA decay in a deadenylation-dependent manner
CNOT1 regulates circadian behaviour through <i>Per2</i> mRNA decay in a deadenylation-dependent manner Open
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology. It has been recently shown that post-transcriptional mech…
View article: Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis Open
View article: Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKIIα-Cre mouse line
Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKIIα-Cre mouse line Open
The CaMKIIα-Cre mouse line, one of the earliest established Cre driver lines, has resulted in over 800 papers to date. Here, we demonstrate that the second most widely used CaMKIIα-Cre line, Tg(Camk2a-cre)2Gsc (or CamiCre), shows ectopic o…
View article: The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation Open
The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4–NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle reg…