Haythem A. Saadeh
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View article: Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against MDA-MB-231 and A549 Cancer Cell Lines
Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against MDA-MB-231 and A549 Cancer Cell Lines Open
View article: Design, synthesis, anticancer properties, and molecular docking of imidazolone derivatives with lipophilic moiety
Design, synthesis, anticancer properties, and molecular docking of imidazolone derivatives with lipophilic moiety Open
As part of an ongoing investigation into imidazolone derivatives with anticancer activities, herein we present the synthesis of a new series of imidazolones with various substituents, including lipophilic and hydrophilic. All synthesized i…
View article: Novel Selenourea-Embedded Coumarin Derivatives as Anticancer Agents on HepG2 and Huh-7 Cells: Synthesis, Biological Evaluation and in Silico Studies
Novel Selenourea-Embedded Coumarin Derivatives as Anticancer Agents on HepG2 and Huh-7 Cells: Synthesis, Biological Evaluation and in Silico Studies Open
View article: Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against MDA-MB-231 and A549 Cancer Cell Lines
Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against MDA-MB-231 and A549 Cancer Cell Lines Open
View article: Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against Mda-Mb-231 and A549 Cancer Cell Lines
Synthesis, Cytotoxicity, and Molecular Docking Studies of Novel Selenourea-Embedded Quinoline and Benzimidazole Derivatives Against Mda-Mb-231 and A549 Cancer Cell Lines Open
View article: First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1,3,4-thiadiazole Derivatives
First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1,3,4-thiadiazole Derivatives Open
N-arylcyanothioformamides are useful coupling components for building key chemical intermediates and biologically active molecules in an expedited and efficient manner. Similarly, substituted (Z)-2-oxo-N-phenylpropanehydrazonoyl chlorides …
View article: Cucurbituril—assisted sensitive fluorescence detection and quantitation of naproxen drug in wastewater samples: Guest-host characterization and HPLC investigation
Cucurbituril—assisted sensitive fluorescence detection and quantitation of naproxen drug in wastewater samples: Guest-host characterization and HPLC investigation Open
Sensitive spectrofluorometric and liquid chromatography with fluorescence detection methods have been developed for detection and determination of naproxen drug in the presence of cucurbit7uril (CB7). Fluorescence signals have been improve…
View article: Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation
Highly bioactive novel aryl-, benzyl-, and piperazine-selenoureas: synthesis, structural characterization and in vitro biological evaluation Open
View article: Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25, 4321
Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25, 4321 Open
The author wishes to make the following correction to this paper [...]
View article: Synthesis and biological applications of some novel 8-Hydroxyquinoline urea and thiourea derivatives
Synthesis and biological applications of some novel 8-Hydroxyquinoline urea and thiourea derivatives Open
A number of novel urea and thiourea derivatives of 8-hydroxyquinoline have been designed, synthesized and evaluated for their anticancer activities. The structures of the new compounds were established by spectroscopic techniques, 1H NMR, …
View article: Benzimidazole–Piperazine–Coumarin/Cucurbit[7]uril Supramolecular Photoinduced Electron Transfer Fluorochromes for Detection of Carnosol by Stimuli-Responsive Dye Displacement and p<i>K</i><sub>a</sub> Tuning
Benzimidazole–Piperazine–Coumarin/Cucurbit[7]uril Supramolecular Photoinduced Electron Transfer Fluorochromes for Detection of Carnosol by Stimuli-Responsive Dye Displacement and p<i>K</i><sub>a</sub> Tuning Open
A new fluorescent dye (4PBZC) comprising coumarin (C), piperazine (P), and benzimidazole (BZ) was designed, prepared, and complexed to cucurbit[7]uril (CB7) to detect carnosol (CAR), an anti-breast cancer drug, in sub-nanomolar concentrati…
View article: Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents
Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents Open
A new series of urea and thiourea derivatives containing benzimidazole group as potential anticancer agents have been designed and synthesized. The structures of the synthesized compounds were characterized and confirmed by spectroscopic t…
View article: Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines Open
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry and biology of this group have attracted the attention o…
View article: Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D<sub>2</sub> and D<sub>3</sub> Dopamine Receptors
Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D<sub>2</sub> and D<sub>3</sub> Dopamine Receptors Open
The search for synthetic selective compounds for G-protein-coupled receptors has provided a myriad of molecules with high selectivity and therapeutic potential. In some cases, however, selectivity is difficult to obtain. For instance, the …