Hazel M. Mitchell
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View article: Obituary: Emeritus Professor Adrian Lee AC BSc PhD FASM (1941–2023)
Obituary: Emeritus Professor Adrian Lee AC BSc PhD FASM (1941–2023) Open
His progression through the academic ranks was a reflection, not only of his outstanding commitment to learning and teaching, but also his stellar research in the field of gut microbiology.During his career, Adrian built a large research t…
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Issue Information Open
Helicobacter is edited by Professor David Y
View article: Issue Information
Issue Information Open
Helicobacter is edited by Professor David Y
View article: Data from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
Data from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study Open
DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case–control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA …
View article: Supplementary Tables from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
Supplementary Tables from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study Open
Table S1, Table S2
View article: Data from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
Data from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study Open
DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case–control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA …
View article: Supplementary Tables from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
Supplementary Tables from DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study Open
Table S1, Table S2
View article: Issue Information
Issue Information Open
Helicobacter is edited by Professor David Y
View article: Issue Information
Issue Information Open
Helicobacter is edited by Professor David Y
View article: Issue Information
Issue Information Open
Helicobacter is edited by Professor David Y
View article: 783Lifetime alcohol intake and stomach cancer risk: a pooled analysis of two prospective cohort studies
783Lifetime alcohol intake and stomach cancer risk: a pooled analysis of two prospective cohort studies Open
Background Alcohol consumption is causally linked to several cancer sites but the evidence for stomach cancer is still inconclusive. We aimed to quantify the association between alcohol intake and risk of stomach cancer, including subtypes…
View article: Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies
Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies Open
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long‐term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We per…
View article: Diet and risk of gastro-oesophageal reflux disease in the Melbourne Collaborative Cohort Study
Diet and risk of gastro-oesophageal reflux disease in the Melbourne Collaborative Cohort Study Open
Objective: To examine associations between diet and risk of developing gastro-oesophageal reflux disease (GERD). Design: Prospective cohort with a median follow-up of 15·8 years. Baseline diet was measured using a FFQ. GERD was defined as …
View article: Strain population structure varies widely across bacterial species and predicts strain colonization in unrelated individuals
Strain population structure varies widely across bacterial species and predicts strain colonization in unrelated individuals Open
Summary The population structure of strains within a bacterial species is poorly defined, despite the functional importance of strain variation in the human gut microbiota on health. Here we analyzed >1000 sequenced bacterial strains from …
View article: DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study Open
DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case–control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA …
View article: Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas Open
Significance Composition of gut microbiota is altered in many human diseases, including inflammatory bowel disease. Some hope that restoring microbiota to a healthy state could help treat such diseases. We have used mice colonized with mic…
View article: Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease
Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease Open
Epithelial barrier injury allows contaminants to cross-over into the blood stream and trigger an inflammatory response, contributing to inflammatory bowel disease (IBD). Currently there is no single test that can reliably diagnose intestin…
View article: Defined microbiota transplant restores Th17/RORγt<sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Defined microbiota transplant restores Th17/RORγt<sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas Open
The building evidence for the contribution of microbiota to human disease has spurred an effort to develop therapies that target the gut microbiota. This is particularly evident in inflammatory bowel diseases, where clinical trials of feca…
View article: Gastrointestinal Pathobionts in Pediatric Crohn’s Disease Patients
Gastrointestinal Pathobionts in Pediatric Crohn’s Disease Patients Open
Crohn’s disease (CD) is an inflammatory disease of the gastrointestinal tract, with a rising incidence worldwide, particularly in children. CD is thought to arise due to an immune response to environmental factors. The role of bacteria in …
View article: Gut Microbiome Analysis Identifies Potential Etiological Factors in Acute Gastroenteritis
Gut Microbiome Analysis Identifies Potential Etiological Factors in Acute Gastroenteritis Open
The morbidity and mortality resulting from acute gastroenteritis and associated chronic sequelae represent a substantial burden on health care systems worldwide. Few studies have investigated changes in the gut microbiome following an epis…
View article: OP019 In faecal microbiota transplantation (FMT) for ulcerative colitis, fusobacterium is associated with lack of remission, while metabolic shifts to starch degradation and short-chain fatty acid production are associated with remission (FOCUS study)
OP019 In faecal microbiota transplantation (FMT) for ulcerative colitis, fusobacterium is associated with lack of remission, while metabolic shifts to starch degradation and short-chain fatty acid production are associated with remission (FOCUS study) Open
In the FOCUS study, multidonor FMT was effective in the treatment of active ulcerative colitis (UC).1 Here we characterise the bacterial taxonomic and functional changes associated with outcome. A total of 314 fecal and 160 colonic biopsy …
View article: The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017
The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017 Open
On March 24 and 25, 2017 researchers and clinicians from around the world met at Temple University in Philadelphia to discuss the current knowledge of Mycobacterium avium ssp. paratuberculosis (MAP) and its relationship to human disease. T…
View article: Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis Open
FMT appears effective in UC remission induction, but long-term durability and safety remain unclear. Additional well-designed controlled studies of FMT in IBD are needed, especially in CD and pouchitis.
View article: P589 Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis
P589 Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis Open
Background: Given the importance of the enteric microbiota in the pathogenesis of the inflammatory bowel diseases, faecal microbiota transplantation (FMT) has been advocated as a potential therapeutic strategy, and has been the recent subj…