Hazem Ghebeh
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View article: Fascin Drives Breast Cancer Cell Proliferation Partly by Modulating the Cell Cycle Checkpoint Regulators of the G1-S Phase
Fascin Drives Breast Cancer Cell Proliferation Partly by Modulating the Cell Cycle Checkpoint Regulators of the G1-S Phase Open
Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide. Despite therapeutic advances, disease relapse and metastasis remain major challenges and drivers of mortality. Fascin, an actin-bundling protein, promotes B…
View article: Homozygous Loss of Function PIK3CD Mutation in Multiple Siblings Leading To B Cell Dysregulation and Autoimmunity
Homozygous Loss of Function PIK3CD Mutation in Multiple Siblings Leading To B Cell Dysregulation and Autoimmunity Open
Phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases that are involved in a diverse array of cellular functions such as growth, metabolism, and migration. Mutations in PIK3CD, which encodes an immune-specific catalytic su…
View article: Profiling of Breast Cancer Stem Cell Types/States Shows the Role of CD44hi/CD24lo-ALDH1hi as an Independent Prognostic Factor After Neoadjuvant Chemotherapy
Profiling of Breast Cancer Stem Cell Types/States Shows the Role of CD44hi/CD24lo-ALDH1hi as an Independent Prognostic Factor After Neoadjuvant Chemotherapy Open
Multiple markers exist for breast cancer stem cells (CSCs), which are believed to represent the phenotypes of various CSC types and/or states. The relationship between each CSC subpopulation/state and the primary hallmarks of cancer has no…
View article: High Tumoral CD24 Expression and Low CD3+ Tumor-Infiltrating Lymphocytes as a Biomarker for High-Risk Locally Advanced Nasopharyngeal Carcinoma
High Tumoral CD24 Expression and Low CD3+ Tumor-Infiltrating Lymphocytes as a Biomarker for High-Risk Locally Advanced Nasopharyngeal Carcinoma Open
Introduction: The limited value of TNM staging in locally advanced (LA) nasopharyngeal carcinoma (NPC), defined as stage III or IV NPC, highlights the need for prognostic markers. Here, we aimed to evaluate the ability of the cancer stem c…
View article: Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis Open
Introduction Metastasis is the major cause of thyroid cancer morbidity and mortality. However, the mechanisms are still poorly understood. Methods We performed genome-wide transcriptome analysis comparing gene expression profile of metasta…
View article: Comparative Analysis of Breast Cancer Metabolomes Highlights Fascin’s Central Role in Regulating Key Pathways Related to Disease Progression
Comparative Analysis of Breast Cancer Metabolomes Highlights Fascin’s Central Role in Regulating Key Pathways Related to Disease Progression Open
Omics technologies provide useful tools for the identification of novel biomarkers in many diseases, including breast cancer, which is the most diagnosed cancer in women worldwide. We and others have reported a central role for the actin-b…
View article: PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis
PD-L1 intrinsically promotes the proliferation of breast cancer cells through the SKP2-p27/p21 axis Open
Background PD-L1 intrinsically promotes tumor progression through multiple mechanisms, which potentially leads to resistance to anti-PD-1/PD-L1 therapies. The intrinsic effect of PD-L1 on breast cancer (BC) cell proliferation has not been …
View article: Locally advanced nasopharyngeal carcinoma in adolescents treated with tomotherapy: Experience at King Faisal Specialist Hospital and Research Centre
Locally advanced nasopharyngeal carcinoma in adolescents treated with tomotherapy: Experience at King Faisal Specialist Hospital and Research Centre Open
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a rare disease worldwide; To the best of our knowledge, there is no established standard of care specifically tailored for the adolescent population. The majority of existing research relies on…
View article: A unique STK4 mutation truncating only the C-terminal SARAH domain results in a mild clinical phenotype despite severe T cell lymphopenia: Case report
A unique STK4 mutation truncating only the C-terminal SARAH domain results in a mild clinical phenotype despite severe T cell lymphopenia: Case report Open
Mutations in STK4 (MST1) are implicated in a form of autosomal recessive combined immunodeficiency, resulting in recurrent infections (especially Epstein-Barr virus viremia), autoimmunity, and cardiac malformations. Here we report a patien…
View article: Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Data from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Data from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Compelling evidences indicate a key role for regulatory T cells (Treg) on the host response to cancer. The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for develo…
View article: Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 2 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 3 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Data from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Data from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Compelling evidences indicate a key role for regulatory T cells (Treg) on the host response to cancer. The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for develo…
View article: Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 1 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 5 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy
Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4<sup>+</sup> Regulatory T Cells: Implications for Immunotherapy Open
Supplement 4 from The Wilms' Tumor Antigen Is a Novel Target for Human CD4+ Regulatory T Cells: Implications for Immunotherapy
View article: Fascin is essential for mammary gland lactogenesis
Fascin is essential for mammary gland lactogenesis Open
Fascin expression has commonly been observed in certain subtypes of breast cancer, where its expression is associated with poor clinical outcome. However, its role in normal mammary gland development has not been elucidated. Here, we used …
View article: Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial Open
Introduction Gemcitabine is a well‐known radiosensitizer. Herein, we tested the efficacy and toxicity of preoperative concurrent infusional gemcitabine and radiotherapy in locally advanced rectal cancer. Patients and Methods This was a pha…
View article: Peripheral Blood Eosinophil Count is Associated with Response to Chemoimmunotherapy in Metastatic Triple-Negative Breast Cancer
Peripheral Blood Eosinophil Count is Associated with Response to Chemoimmunotherapy in Metastatic Triple-Negative Breast Cancer Open
Introduction: There is evidence for an association between peripheral blood eosinophil count (PBEC) and response to cancer immunotherapy; however, such data is limited in metastatic triple-negative breast cancer (mTNBC). Patients…
View article: Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression
Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression Open
Recent years have witnessed major progress in development of novel therapeutic agents such as chemotherapy, targeted therapy and immune checkpoint inhibitors for breast cancer. However, cancer-related death remains high especially in tripl…
View article: Weekly Paclitaxel given concurrently with Durvalumab has a favorable safety profile in triple-negative metastatic breast cancer
Weekly Paclitaxel given concurrently with Durvalumab has a favorable safety profile in triple-negative metastatic breast cancer Open
Therapeutic anti-PD-L1 antibodies are safe as a monotherapy, albeit with minimal efficacy in triple-negative breast cancer (TNBC). This trial aimed to test the safety and efficacy of Durvalumab and Paclitaxel in metastatic TNBC. In this op…
View article: Higher PD-L1 Immunohistochemical Detection Signal in Frozen Compared to Matched Paraffin-Embedded Formalin-Fixed Tissues
Higher PD-L1 Immunohistochemical Detection Signal in Frozen Compared to Matched Paraffin-Embedded Formalin-Fixed Tissues Open
Purpose: Response to anti-PD-L1/PD-1 immunotherapy correlates with PD-L1 expression in breast cancer. However, the prevalence of PD-L1 positive breast cancer is variable, which could be due to differences in the population/cohort of patien…
View article: Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking
Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking Open
Membrane trafficking is a complex, essential process in eukaryotic cells responsible for protein transport and processing. Deficiencies in vacuolar protein sorting (VPS) proteins, key regulators of trafficking, cause abnormal intracellular…
View article: AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1
AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 Open
The AU-rich element RNA-binding protein 1 (AUF1) is an RNA-binding protein, which can both stabilize and destabilize the transcripts of several cancer-related genes. Since epithelial-to-mesenchymal transition (EMT) and the acquisition of c…
View article: Fascin Activates β-Catenin Signaling and Promotes Breast Cancer Stem Cell Function Mainly Through Focal Adhesion Kinase (FAK): Relation With Disease Progression
Fascin Activates β-Catenin Signaling and Promotes Breast Cancer Stem Cell Function Mainly Through Focal Adhesion Kinase (FAK): Relation With Disease Progression Open
Cancer stem cells (CSCs), a rare population of tumor cells with high self-renewability potential, have gained increasing attention due to their contribution to chemoresistance and metastasis. We have previously demonstrated a critical role…