Hazem K. Ghneim
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View article: Optimizing Se- methylselenocysteine concentration to enhance glutathioneperoxidase 1 expression and mitigate oxidative stress in senescent humanfibroblast
Optimizing Se- methylselenocysteine concentration to enhance glutathioneperoxidase 1 expression and mitigate oxidative stress in senescent humanfibroblast Open
Glutathione peroxidase 1 (GPx1) activity, gene expression, and several oxidative stress (OS) marker levels were investigated in the senescent passage (P) 20, 25, and 30 fibroblasts cultured in media supplemented with increasing Se-Methylse…
View article: Fe2O3-type iron oxide nanoparticles from Aerva lanata leaf extract exhibit antibiofilm, discriminatory toxicity in cancer cells, and theranostic against oxidative stress in zebrafish
Fe2O3-type iron oxide nanoparticles from Aerva lanata leaf extract exhibit antibiofilm, discriminatory toxicity in cancer cells, and theranostic against oxidative stress in zebrafish Open
In the study, phytosynthesized iron oxide nanoparticles (Fe NPs) from Aerva lanata leaf extract. The phytosynthesized Fe NPs were characterized and assessed for multi-biofunctional features such as antioxidant, antibiofilm, and theranostic…
View article: P-123. Unlocking Synergy: Exploring Combination Therapies in Whipple's Disease for Enhanced Clinical Efficacy
P-123. Unlocking Synergy: Exploring Combination Therapies in Whipple's Disease for Enhanced Clinical Efficacy Open
Background Whipple's disease (WD) is a rare chronic multisystemic infection that primarily affects the gastrointestinal tract. There are no FDA-approved treatments for WD. Standard treatment involves prolonged antibiotic regimens that can …
View article: Unveiling the Phenolic Profiling of Moroccan <i>Ferula communis</i> L. Fruits: A Combination of <i>In Silico</i> and <i>In Vivo</i> Protective Effect Against Methotrexate‐Induced Hepato‐Renal Dysfunction
Unveiling the Phenolic Profiling of Moroccan <i>Ferula communis</i> L. Fruits: A Combination of <i>In Silico</i> and <i>In Vivo</i> Protective Effect Against Methotrexate‐Induced Hepato‐Renal Dysfunction Open
Background: Methotrexate (MTX) is associated with several side effects, including hepatic and renal toxicities, which limit its effectiveness as an anticancer medication. These toxicities can lead to hepatotoxicity, nephrotoxicity, and pot…
View article: Exploring the essence of celery seeds (Apium graveolens L.): Innovations in microwave-assisted hydrodistillation for essential oil extraction using in vitro, in vivo and in silico studies
Exploring the essence of celery seeds (Apium graveolens L.): Innovations in microwave-assisted hydrodistillation for essential oil extraction using in vitro, in vivo and in silico studies Open
The version of record of this article, first published in Arabian Journal of Chemistry, is available online at Publisher’s website: HTTPS://doi.org/10.1016/j.arabjc.2024.105726
View article: Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor
Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor Open
Introduction: Epilepsy is a chronic brain disease characterized by repeated seizures and caused by excessive glutamate receptor activation. Many plants are traditionally used in the treatment of this disease. This study aimed to evaluate t…
View article: Effects of unpredictable chronic mild stress on the cellular redox state and mitochondrial energy homeostasis in rat adipose tissue: A comprehensive metabolic study
Effects of unpredictable chronic mild stress on the cellular redox state and mitochondrial energy homeostasis in rat adipose tissue: A comprehensive metabolic study Open
Unpredictable chronic mild stress (UCMS) leads to variable metabolic effects. Oxidative stress (OS) of adipose tissue (AT) and mitochondrial energy homeostasis is little investigated. This work studied the effects of UCMS on OS and the ant…
View article: Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention
Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention Open
Background and Objectives: Obesity is a chronic inflammatory condition and is considered a major risk factor for cardiovascular disease (CVD). The effects of obesity management via sleeve gastrectomy (SG) and lifestyle intervention (LS) on…
View article: An Insight into the Impact of Serum Tellurium, Thallium, Osmium and Antimony on the Antioxidant/Redox Status of PCOS Patients: A Comprehensive Study
An Insight into the Impact of Serum Tellurium, Thallium, Osmium and Antimony on the Antioxidant/Redox Status of PCOS Patients: A Comprehensive Study Open
Humans exploit heavy metals for various industrial and economic reasons. Although some heavy metals are essential for normal physiology, others such as Tellurium (Te), Thallium (TI), antimony (Sb), and Osmium (Os) are highly toxic and can …
View article: Green synthesis of <i>Kickxia elatine</i>-induced silver nanoparticles and their role as anti-acetylcholinesterase in the treatment of Alzheimer’s disease
Green synthesis of <i>Kickxia elatine</i>-induced silver nanoparticles and their role as anti-acetylcholinesterase in the treatment of Alzheimer’s disease Open
The synthesis of silver nanoparticles (AgNPs) by the green method is favored as compared to chemical synthesis due to their appreciable properties of less toxicity and simple synthesis. The current study designed the biosynthesis of AgNPs …
View article: Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3
Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3 Open
Due to poor diagnosis breast cancer in women has emerged as the most common cause of death disease in developing countries. Medicinal plants have been used for thousands of years and can be useful in healthcare, especially in developing co…
View article: Patterns of Dyslipidemia in the Anemic and Nonanemic Hypertensive Saudi Population: A Cross-Sectional Study
Patterns of Dyslipidemia in the Anemic and Nonanemic Hypertensive Saudi Population: A Cross-Sectional Study Open
BACKGROUND: Risk factors of cardiovascular disease include dyslipidemia, hypertension (HTN), and anemia. Our objective is to assess the patterns of dyslipidemia in the anemic and non-anemic hypertensive Saudi population. METHODS: A retrosp…
View article: Isolated and Combined Effect of Age and Gender on Neutrophil–Lymphocyte Ratio in the Hyperglycemic Saudi Population
Isolated and Combined Effect of Age and Gender on Neutrophil–Lymphocyte Ratio in the Hyperglycemic Saudi Population Open
Inflammation is pivotal to the pathogenesis of diabetes mellitus (DM), but pathological alterations of the neutrophil–lymphocyte ratio (NLR), an emerging inflammatory index in DM management, remains understudied. The aim of this study is t…
View article: Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts
Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts Open
There is a paucity of detailed data related to the effect of senescence on the mitochondrial antioxidant capacity and redox state of senescent human cells. Activities of TCA cycle enzymes, respiratory chain complexes, hydrogen peroxide (H<…
View article: Detection of Novel Biallelic Causative Variants in COL7A1 Gene by Whole-Exome Sequencing, Resulting in Congenital Recessive Dystrophic Epidermolysis Bullosa in Three Unrelated Families
Detection of Novel Biallelic Causative Variants in COL7A1 Gene by Whole-Exome Sequencing, Resulting in Congenital Recessive Dystrophic Epidermolysis Bullosa in Three Unrelated Families Open
Background: Dystrophic Epidermolysis bullosa (DEB) is a rare, severe subtype of epidermolysis bullosa (EB), characterized by blisters and miliary rashes of the skin. Dystrophic EB (DEB) includes variants inherited both in an autosomal-domi…
View article: Antioxidant and Antimicrobial Activities of Chemically-Characterized Essential Oil from Artemisia aragonensis Lam. against Drug-Resistant Microbes
Antioxidant and Antimicrobial Activities of Chemically-Characterized Essential Oil from Artemisia aragonensis Lam. against Drug-Resistant Microbes Open
This study investigated the chemical composition, antioxidant and antimicrobial activity of essential oil extracted from Artemisia aragonensis Lam. (EOA). Hydrodistillation was employed to extract EOA. Gas chromatography with flame ionizat…
View article: Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts
Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts Open
Selenium enhances the cellular antioxidant capacity and alleviates oxidative stress. We investigated the transcriptional and enzymatic activities of selenium-dependent glutathione peroxidase 1 and thioredoxin reductase 1 (TrxR1), and level…
View article: Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS)
Antioxidant status in relation to heavy metals induced oxidative stress in patients with polycystic ovarian syndrome (PCOS) Open
View article: Glutathione and oxidized nicotinamide adenine dinucleotide (NAD<sup>+</sup>) redox status in plasma and placental tissue of Saudi patients with intrauterine growth restriction
Glutathione and oxidized nicotinamide adenine dinucleotide (NAD<sup>+</sup>) redox status in plasma and placental tissue of Saudi patients with intrauterine growth restriction Open
Intrauterine growth restriction patients show a metabolic shift in favor of oxidation compared to HP women.
View article: Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes
Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes Open
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell death of red blood cells (RBCs), may account for CIA as it is triggered by clinic…
View article: Molecular and biochemical investigations of key antioxidant/oxidant molecules in Saudi patients with recurrent miscarriage
Molecular and biochemical investigations of key antioxidant/oxidant molecules in Saudi patients with recurrent miscarriage Open
The present study was undertaken to: i) Determine the levels of oxidative stress (OS) markers, malondialdehyde (MDA), superoxide anions (SOA) and hydrogen peroxide (H2O2), in both plasma and placental tissues of recur…
View article: Screening for differentially‑expressed microRNA biomarkers in�Saudi colorectal cancer patients by small RNA deep sequencing
Screening for differentially‑expressed microRNA biomarkers in�Saudi colorectal cancer patients by small RNA deep sequencing Open
Colorectal cancer (CRC) is mostly diagnosed at late stages leading to high mortality rates due to the scarcity of efficient screening approaches exhibiting high diagnostic utility. The current study employed a small‑RNA deep‑sequencing app…
View article: Selenium Concentrations for Maximisation of Thioredoxin Reductase 2 Activity and Upregulation of Its Gene Transcripts in Senescent Human Fibroblasts
Selenium Concentrations for Maximisation of Thioredoxin Reductase 2 Activity and Upregulation of Its Gene Transcripts in Senescent Human Fibroblasts Open
Thioredoxin reductase 2 (TR2) activity, its gene transcripts, and hydrogen peroxide (H2O2) generation were examined in biochemically identified early-senescent P20 and senescent P30 fibroblasts subcultured in media (MEM2–MEM8) containing S…
View article: Ascorbate ameliorates Echis coloratus venom-induced oxidative stress in human fibroblasts
Ascorbate ameliorates Echis coloratus venom-induced oxidative stress in human fibroblasts Open
Reports related to the effects of Echis coloratus venom (EcV) on the antioxidant capacity of human tissues is very scarce. The present study was undertaken to investigate the activities and gene expression levels of glutathione pero…
View article: The effect of<i>Echis coloratus</i>venom on biochemical and molecular markers of the antioxidant capacity in human fibroblasts
The effect of<i>Echis coloratus</i>venom on biochemical and molecular markers of the antioxidant capacity in human fibroblasts Open
This study was undertaken to examine the activities and levels of major antioxidants/oxidants in cultured human fibroblasts incubated with a sublethal dose of Echis coloratus venom (EcV). Glutathione peroxidase (GPx), catalase (CAT), super…
View article: Effect of iron deficiency anemia on glycosylated hemoglobin level (HbA1c) in non-diabetic patients in Riyadh region of Saudi Arabia
Effect of iron deficiency anemia on glycosylated hemoglobin level (HbA1c) in non-diabetic patients in Riyadh region of Saudi Arabia Open
View article: Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage
Superoxide dismutase activity and gene expression levels in Saudi women with recurrent miscarriage Open
The antioxidant activities of superoxide dismutase 1 (SOD1) and SOD2, as well as the levels of the oxidant superoxide anion (SOA) and the micronutrients zinc (Zn), copper (Cu) and manganese (Mn), were assayed in plasma, whole blood and pla…
View article: Biochemical Markers of Oxidative Stress in Saudi Women with Recurrent Miscarriage
Biochemical Markers of Oxidative Stress in Saudi Women with Recurrent Miscarriage Open
This study was undertaken to investigate the antioxidant/oxidant status in recurrent miscarriage patients. Antioxidants including glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR), reduced glutathione (GSH) and selen…
View article: Expression profiling of selected microRNA signatures in plasma and tissues of Saudi colorectal cancer patients by qPCR
Expression profiling of selected microRNA signatures in plasma and tissues of Saudi colorectal cancer patients by qPCR Open
MicroRNAs (miRNAs or miRs) have been advocated as potentially robust and highly stable biomarkers of diverse disease conditions including cancer. The primary aim of this study was two-fold: i) to profile the expression levels of selected m…
View article: The Effect of<i>Walterinnesia aegyptia</i>Venom Proteins on TCA Cycle Activity and Mitochondrial NAD<sup>+</sup>-Redox State in Cultured Human Fibroblasts
The Effect of<i>Walterinnesia aegyptia</i>Venom Proteins on TCA Cycle Activity and Mitochondrial NAD<sup>+</sup>-Redox State in Cultured Human Fibroblasts Open
Fibroblast cultures were used to study the effects of crude Walterinnesia aegyptia venom and its F1–F7 protein fractions on TCA cycle enzyme activities and mitochondrial NAD-redox state. Confluent cells were incubated with 10 μ g of venom …