Ho‐Chul Shin
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View article: Sebum’s effect on wound healing and pigmentation in mice
Sebum’s effect on wound healing and pigmentation in mice Open
Background Wound healing is often followed by postinflammatory hyperpigmentation (PIH), which commonly develops in sebum-poor areas. Objectives To investigate the effects of sebum on wound healing, especially relative to basement membrane …
View article: South Korea’s National Animal Welfare Policies in Comparison to Legal Frameworks and Systems in Other Countries
South Korea’s National Animal Welfare Policies in Comparison to Legal Frameworks and Systems in Other Countries Open
It is essential to establish a normative framework that ensures the harmonious coexistence of humans and animals from legal and institutional perspectives. This study classifies and compares animal welfare policies in welfare states, ident…
View article: Concurrent Optimizations of Efficacy and Blood–Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson’s Disease Therapeutics
Concurrent Optimizations of Efficacy and Blood–Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson’s Disease Therapeutics Open
The elevated activity of leucine-rich repeat kinase 2 (LRRK2) is implicated in the pathogenesis of Parkinson's disease (PD). The quest for effective LRRK2 inhibitors has been impeded by the formidable challenge of crossing the blood-brain …
View article: Supplementary Figure 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Figure 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 320K, Acute histopathologic effects of paclitaxel-containing micelles and Triolimus.
View article: Supplementary Figure Legend from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Figure Legend from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 66K.
View article: Data from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Data from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
Triolimus is a first-in-class, multidrug-loaded micelle containing paclitaxel, rapamycin, and 17-AAG. In this study, we examine the antitumor mechanisms of action, efficacy, and toxicity of Triolimus in vitro and in vivo. In vitro cytotoxi…
View article: Supplementary Figure Legend from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Figure Legend from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 66K.
View article: Supplementary Table 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Table 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 109K, Toxicity of paclitaxel-containing micelles and Triolimus.
View article: Supplementary Figure 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Figure 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 320K, Acute histopathologic effects of paclitaxel-containing micelles and Triolimus.
View article: Data from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Data from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
Triolimus is a first-in-class, multidrug-loaded micelle containing paclitaxel, rapamycin, and 17-AAG. In this study, we examine the antitumor mechanisms of action, efficacy, and toxicity of Triolimus in vitro and in vivo. In vitro cytotoxi…
View article: Supplementary Table 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG
Supplementary Table 1 from Antitumor Activity of Triolimus: A Novel Multidrug-Loaded Micelle Containing Paclitaxel, Rapamycin, and 17-AAG Open
PDF file, 109K, Toxicity of paclitaxel-containing micelles and Triolimus.
View article: Survival of Illegal Fentanyl Sales in the Twittersphere and Tumblr Sphere: A Cross-Sectional Forensics Approach
Survival of Illegal Fentanyl Sales in the Twittersphere and Tumblr Sphere: A Cross-Sectional Forensics Approach Open
Social media offer valuable knowledge about opioid narcotics' risks but are also commonly used to sell them.To determine how drug dealers avoid social media surveillance, the cross-sectional study used fentanyl-related data from Twittersph…
View article: Effect of wind-driven rain on runoff, infiltration and soil erosion
Effect of wind-driven rain on runoff, infiltration and soil erosion Open
Soil erosion is a result of detachment and transport of particles or small aggregates from the soil surface. Previous research has predominantly focused on studying the effects of either rainfall or wind on soil erosion processes as separa…
View article: Evaluation of pedotransfer functions to estimate some of soil hydraulic characteristics in North Africa: A case study from Morocco
Evaluation of pedotransfer functions to estimate some of soil hydraulic characteristics in North Africa: A case study from Morocco Open
Soil hydraulic properties are an important factor to optimize and adapt water management for a given crop. Pedotransfer functions (PTFs) present a solution to predict soil variables such as hydraulic properties, using fundamental soil prop…
View article: X-MAS: Extremely Large-Scale Multi-Modal Sensor Dataset for Outdoor Surveillance in Real Environments
X-MAS: Extremely Large-Scale Multi-Modal Sensor Dataset for Outdoor Surveillance in Real Environments Open
In robotics and computer vision communities, extensive studies have been widely conducted regarding surveillance tasks, including human detection, tracking, and motion recognition with a camera. Additionally, deep learning algorithms are w…
View article: Simultaneous Quantification of Chloramphenicol, Thiamphenicol, Florfenicol, and Florfenicol Amine in Animal and Aquaculture Products Using Liquid Chromatography-Tandem Mass Spectrometry
Simultaneous Quantification of Chloramphenicol, Thiamphenicol, Florfenicol, and Florfenicol Amine in Animal and Aquaculture Products Using Liquid Chromatography-Tandem Mass Spectrometry Open
The accumulation of antimicrobial residues in edible animal products and aquaculture products could pose health concerns to unsuspecting consumers. Hence, this study aimed to develop a validated method for simultaneous quantification of ch…
View article: Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation
Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation Open
Significance A major yet perplexing question in the field of necroptosis is the role and involvement of necroptosis in cancer cells. Many cancer cells have protective mechanisms against necroptosis, but the underlying mechanism remains elu…
View article: <p>Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers</p>
Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers Open
Pharmacokinetic parameters including the Cmax and AUC0-t determined after oral administration of the two formulations in healthy Korean male volunteers showed that the differences between the formulations (tablet vs soft capsule) were not …
View article: Targeted knockout of a chemokine-like gene increases anxiety and fear responses
Targeted knockout of a chemokine-like gene increases anxiety and fear responses Open
Significance Emotion-related responses, such as fear and anxiety, are important behavioral phenomena in most animal species, as well as in humans. However, the underlying mechanisms of fear and anxiety in animals and in humans are still la…
View article: Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling
Ligand-Dependent Interaction of PPARδ With T-Cell Protein Tyrosine Phosphatase 45 Enhances Insulin Signaling Open
Peroxisome proliferator–activated receptor (PPAR) δ plays a pivotal role in metabolic homeostasis through its effect on insulin signaling. Although diverse genomic actions of PPARδ are postulated, the specific molecular mechanisms whereby …
View article: Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization
Structure of Full-Length SMC and Rearrangements Required for Chromosome Organization Open
Multi-subunit SMC complexes control chromosome superstructure and promote chromosome disjunction, conceivably by actively translocating along DNA double helices. SMC subunits comprise an ABC ATPase "head" and a "hinge" dimerization domain …
View article: Sustainability of CD24 expression, cell proliferation and migration, cisplatin-resistance, and caspase-3 expression during mesenchymal-epithelial transition induced by the removal of TGF-β1 in A549 lung cancer cells
Sustainability of CD24 expression, cell proliferation and migration, cisplatin-resistance, and caspase-3 expression during mesenchymal-epithelial transition induced by the removal of TGF-β1 in A549 lung cancer cells Open
Epithelial-mesenchymal transition (EMT) is a notable mechanism underlying cancer cell metastasis. Transforming growth factor β1 (TGF-β1) has been used to induce EMT; however, there is a lack of information regarding the role of TGF-β1 in m…
View article: A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release
A Dalbergia odorifera extract improves the survival of endotoxemia model mice by inhibiting HMGB1 release Open
These results suggest that DOE confers resistance to LPS-triggered inflammation through NO-mediated inhibitory effects on HMGB1 release.