Wen-Jia Chen
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View article: Causal relationship between subhealth status and pan-cancer risk: A Mendelian randomization study
Causal relationship between subhealth status and pan-cancer risk: A Mendelian randomization study Open
Subhealth status (SHS), an intermediate state between health and disease, is increasingly prevalent, yet its potential causal role in cancer remains unclear. Leveraging publicly available genome-wide association data from the Integrative E…
View article: IL-3/STAT5/miR-155-5p axis supports stem-related pathway reprogramming in TNBC
IL-3/STAT5/miR-155-5p axis supports stem-related pathway reprogramming in TNBC Open
Background Triple negative breast cancer (TNBC) remains one of the most aggressive subtypes of cancer with a poor prognosis and limited treatment options. Building on our previous findings of elevated Interleukin-3-Receptor-α (IL-3Rα) expr…
View article: Cyclophosphamide for severe T-DXd-induced interstitial lung disease in low-HER2 breast cancer: a case report and mechanistic insights
Cyclophosphamide for severe T-DXd-induced interstitial lung disease in low-HER2 breast cancer: a case report and mechanistic insights Open
Background Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has shown significant efficacy in treating both HER2-positive and low-HER2 breast cancers. However, interstitial lung disease (ILD) remains a major adverse …
View article: Catalase: The golden key to regulate oxidative stress in breast cancer
Catalase: The golden key to regulate oxidative stress in breast cancer Open
Catalase (CAT) is a kind of tetrameric protein in the human body, play as a key regulator for controlling oxidative stress. The main function of CAT is to regulate the concentration of hydrogen peroxide (H2O2) by catalyzing the decompositi…
View article: Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database
Drug-associated serotonin syndrome in elderly patients: a comprehensive disproportionality analysis based on the FAERS database Open
Background This study aims to identify drugs associated with serotonin syndrome in elderly patients by utilizing the FDA Adverse Event Reporting System (FAERS), to provide evidence-based references for safe clinical medication practices. M…
View article: Intraoperative evaluation of metastatic SLNs with NIRF imaging assisted by artificial intelligence in breast cancers
Intraoperative evaluation of metastatic SLNs with NIRF imaging assisted by artificial intelligence in breast cancers Open
Background: Near-infrared fluorescence (NIRF) imaging with indocyanine green is widely employed for sentinel lymph node (SLN) biopsy in breast cancer but cannot assess SLN metastatic status. Current intraoperative assessment relies on froz…
View article: The intervention effect of physical and mental exercise on young adults internet addiction disorder: a systematic review and Bayesian model analysis
The intervention effect of physical and mental exercise on young adults internet addiction disorder: a systematic review and Bayesian model analysis Open
Background As a behavioral addiction, internet addiction disorder has become a global problem that seriously affects people’s mental health. Although physical and mental exercise is believed to help alleviate related symptoms, there is cur…
View article: Aptamer-based NIR II imaging for breast cancer surgical resection
Aptamer-based NIR II imaging for breast cancer surgical resection Open
The accuracy of intraoperative tumor margin assessment is the main challenge in breast conserving surgery (BCS). NIR-II fluorescence-guided surgery enables surgeons to visualize the tumor margins dynamically in real time and facilitate the…
View article: Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer
Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer Open
Colorectal cancer (CRC) ranks as the third most common cancer globally and the second leading cause of cancer-related deaths, representing a significant health burden. Despite advancements in traditional treatments such as surgery, chemoth…
View article: Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal‐Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis
Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal‐Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory disease of the central nervous system, driven by T‐cell mediated immune responses. Studying T‐cell receptor (TCR) clonotypes specific to MS in distinct populations can provide …
View article: NOTCH1 combined with chemotherapy synergistically inhibits triple-negative breast cancer
NOTCH1 combined with chemotherapy synergistically inhibits triple-negative breast cancer Open
BACKGROUND Chemotherapy for triple-negative breast cancer (TNBC) is often limited in efficacy due to drug resistance. The NOTCH1 pathway significantly contributes to the advancement of tumors, but its mechanism of action in sensitizing TNB…
View article: Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications
Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications Open
Objective This study aimed to evaluate the prognostic significance of epithelial zinc finger protein (EZF/KLF4) in lung adenocarcinoma (LAC) and explore its potential roles in tumor progression and immune regulation. Methods and Materials …
View article: A network meta-analysis of mind–body exercise interventions for internet addiction symptoms in young adults
A network meta-analysis of mind–body exercise interventions for internet addiction symptoms in young adults Open
Background Internet Addiction Disorder (IAD) is a recurrent mental illness. It severely impacts both physical and mental health, leading to physiological symptoms such as neurological dysfunction and immunosuppression. This condition signi…
View article: Mutational status of RAS, SMAD4 and APC predicts survival after resection of colorectal liver metastases in Chinese patients: prognostic stratification based on genetic sequencing data of multiple somatic genes
Mutational status of RAS, SMAD4 and APC predicts survival after resection of colorectal liver metastases in Chinese patients: prognostic stratification based on genetic sequencing data of multiple somatic genes Open
In Chinese patients, the mutational status of RAS, SMAD4, and APC was significantly associated with survival after CRLM resection. The three-gene scoring system provided information on prognostic stratification for survival, which can be u…
View article: Corrigendum: Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study
Corrigendum: Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study Open
[This corrects the article DOI: 10.3389/fphar.2025.1501634.].
View article: Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study
Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study Open
Background To develop a rational and standardized traditional Chinese medicine (TCM) good practice recommendation (GPR) methodology model that guides the formulation of recommendations grounded in clinical experience. Methods We adopted an…
View article: Risk assessment and predictive modeling of suicide in multiple myeloma patients
Risk assessment and predictive modeling of suicide in multiple myeloma patients Open
Utilizing the factors and predictive model for suicide risk among MM survivors allows for earlier identification and intervention, significantly enhancing their quality of life and psychological relief in the context of improved MM surviva…
View article: Tumor Heterogeneity of STEAP4 in Malignant Progression of Oral Squamous Cell Carcinoma
Tumor Heterogeneity of STEAP4 in Malignant Progression of Oral Squamous Cell Carcinoma Open
Background: Recent research suggests that STEAP4, a metalloreductase in vivo, plays a crucial role in various types of tumorigeneses, especially in gastrointestinal cancers. However, few oncogenes have been reported in oral squamous cell c…
View article: Sine oculis homeobox homolog family function in gastrointestinal cancer: Progression and comprehensive analysis
Sine oculis homeobox homolog family function in gastrointestinal cancer: Progression and comprehensive analysis Open
The sine oculis homeobox homolog (SIX) family, a group of transcription factors characterized by a conserved DNA-binding homology domain, plays a critical role in orchestrating embryonic development and organogenesis across various organis…
View article: Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies
Nuclear pore complex protein RANBP2 and related SUMOylation in solid malignancies Open
The growing interest in post-translational protein modification, particularly in SUMOylation, is driven by its crucial role in cell cycle regulation. SUMOylation affects various cell cycle regulators, including oncogenes, suggesting its re…
View article: Oropharyngeal microbiome profiling and its association with age and heart failure in the elderly population from the northernmost province of China
Oropharyngeal microbiome profiling and its association with age and heart failure in the elderly population from the northernmost province of China Open
Respiratory tract infections are the most common triggers for heart failure in elderly people. The healthy respiratory commensal microbiota can prevent invasion by infectious pathogens and decrease the risk of respiratory tract infections.…
View article: Efficacy and safety of simple analgesics for acute treatment of episodic tension-type headache in adults: a network meta-analysis
Efficacy and safety of simple analgesics for acute treatment of episodic tension-type headache in adults: a network meta-analysis Open
Tension-type headache is the most common type of primary headache and results in a huge socioeconomic burden. This network meta-analysis (NMA) aimed to compare the efficacy and safety of simple analgesics for the treatment of episodic tens…
View article: Exploring the Association between Cathepsin B and Parkinson’s Disease
Exploring the Association between Cathepsin B and Parkinson’s Disease Open
Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator. Methods: We used summary-lev…
View article: Effect of tissue factor pathway inhibitor on the pyroptosis of vascular smooth muscle cells induced by angiotensin II
Effect of tissue factor pathway inhibitor on the pyroptosis of vascular smooth muscle cells induced by angiotensin II Open
Ang II may induce pyroptosis in VSMCs by activating NLRP3. rTFPI can inhibit Ang II-induced VSMC pyroptosis. Furthermore, rTFPI might exert this effect by inhibiting the NLRP3 pathway and therefore play an important role in the treatment o…