Liang Yu
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View article: Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera
Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera Open
Tumor-infiltrating regulatory T (Treg) cells contribute to immune evasion and are associated with poor prognosis in solid tumors. While CD47 blockade has demonstrated efficacy in hematologic malignancies, its application in solid tumors is…
View article: The trilateral crosstalk of TGF β1-ROS-Nrf2 axis in fibrosis: Decoding mechanistic networks for precision therapeutics
The trilateral crosstalk of TGF β1-ROS-Nrf2 axis in fibrosis: Decoding mechanistic networks for precision therapeutics Open
Fibrosis, a hallmark pathological process in numerous chronic diseases, is characterized by the excessive accumulation of extracellular matrix (ECM) components, primarily driven by activated myofibroblasts. This dysregulated tissue remodel…
View article: Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial
Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial Open
We aimed to determine the effect of semaglutide on patients with acute large vessel occlusion (LVO) receiving endovascular therapy (EVT). In this phase 2, investigator-initiated, multicenter, prospective, randomized, open-label, blinded en…
View article: Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy Open
The lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency causes severe autoimmune diseases and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) loss in humans. However, the impact of LRBA on antitumor immunity remai…
View article: Refractive outcome and visual quality of Ray-Tracing Guided LASIK: a prospective study
Refractive outcome and visual quality of Ray-Tracing Guided LASIK: a prospective study Open
Purpose This study aimed to evaluate the safety and effectiveness of Ray-Tracing Guided LASIK surgery and to compare the refractive outcomes and visual quality between patients with spherical equivalent (SEQ) differences of ≤ 0.75D and > 0…
View article: Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System
Leveraging Transfection Dose Streamlines the Establishment of a Chinese Hamster Ovary Cell Targeted Integration System Open
Targeted integration (TI) expression system has emerged as an alternative to random integration in cell line development (CLD) involved in biologics development and manufacturing. A key element of a robust TI CLD system is the construction…
View article: Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by <i>Sporisorium scitamineum</i> : A Comprehensive Review
Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by <i>Sporisorium scitamineum</i> : A Comprehensive Review Open
Sugarcane smut, caused by the fungus Sporisorium scitamineum , is a devastating disease that threatens sugar production, leading to significant yield losses. The pathogen disrupts sugarcane growth by forming whip‐like structures filled wit…
View article: Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: mechanisms and therapeutic potential
Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: mechanisms and therapeutic potential Open
Ferroptosis is an iron-dependent form of programmed cell death primarily characterized by the inactivation of glutathione peroxidase 4 (GPX4), accumulation of lipid peroxides (LPO), and disruption of intracellular antioxidant defenses. Rec…
View article: Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster
Trade-Offs and Synergies Among Habitat, Water, and Carbon Services Driven by Urbanization: A Spatiotemporal Analysis of the Chang-Zhu-Tan City Cluster Open
Understanding the evolution of ecosystem services (ESs) is crucial for sustainable development in rapidly urbanizing regions. This study quantifies the spatiotemporal evolution of habitat quality (HQ), water yield (WY), and carbon storage …
View article: Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing
Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing Open
Acute kidney injury (AKI) is a clinically significant syndrome, characterized by high mortality rates and the potential for progression to chronic kidney disease. Potassium sorbate (PS), a widely‐used food preservative with a high safety p…
View article: Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota
Protective effects of Angelica sinensis polysaccharide on chemotherapy-injured rats with premature ovarian insufficiency and its impact on gut microbiota Open
Objective This study aimed to investigate the therapeutic effects and action mechanisms of Angelica sinensis polysaccharides (ASP) on a chemotherapy-induced premature ovarian insufficiency (POI) rat model along with screening for the optim…
View article: Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study
Prediction of the Ki-67 proliferation index in lung adenocarcinoma using an interpretable CT-based deep learning radiomics model: a two-center study Open
Purpose To develop an interpretable computed tomography (CT)-based deep learning radiomics (DLR) model that integrates deep learning (DL) and radiomics features to predict the preoperative Ki-67 proliferation index in lung adenocarcinoma. …
View article: Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism
Efficient n‐Doping of Organic Semiconductors via a Broadly Applicable Nucleophilic‐Attack Mechanism Open
The development of efficient and broadly applicable n‐doping strategies for organic semiconductors (OSCs) is crucial for advancing the performance of various organic electronic devices. Here, a novel nucleophilic‐attack n‐doping mechanism …
View article: Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19
Competitive dynamics of ST764 and ST5 MRSA in a new tertiary ICU: enhanced hospital adaptation via agrC mutations post-COVID-19 Open
Environmental contamination is the primary source of MRSA transmission in ICUs. The agrC-T43I mutation drives ST5 dominance post-pandemic by enhancing biofilm-dependent persistence, underscoring the need for genomic surveillance to guide i…
View article: Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations
Unraveling the mechanism of tetracycline-induced renal injury: an evaluation of drug safety based on network toxicology and molecular dynamics simulations Open
Background Tetracyline, a widely used antibiotic, is associated with nephrotoxicity, though its underlying mechanisms require further investigation. Methods We investigated the toxicological process of tetracycline-induced renal injury usi…
View article: Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials
Haematological toxicities with targeted drugs in tumors: A systematic review and network meta-analysis of randomized controlled trials Open
Objective: Tumor-targeted drug monotherapy or chemotherapy is becoming increasingly important in cancer treatment, yet the concomitant issue of hematological toxicities is gradually gaining attention. Existing studies lack a comprehensive …
View article: Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation
Exploring the anti-AML mechanisms of compound zhebei granule via integrated network pharmacology, transcriptomic sequencing, and experimental validation Open
Background: Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. In recent years, the clinical application of the Bcl-2 inhibitor Venetoclax (VEN) has significantly improved remission rates and short-term surviva…
View article: Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus
Independent and joint associations of sleep quality and physical activity with glycaemic control in patients with type 2 diabetes mellitus Open
Background Although determinants of glycaemic control in type 2 diabetes mellitus (T2DM) have been extensively investigated, the joint influence of sleep quality and physical activity (PA) remains insufficiently studied. We aimed to examin…
View article: Engineered nano-bacteria hybrids for precision cancer immunotherapy
Engineered nano-bacteria hybrids for precision cancer immunotherapy Open
Bacterial therapy has emerged as a promising modality in precision cancer immunotherapy, leveraging bacteria's innate tumor-homing ability, immunostimulatory properties, and engineering flexibility to overcome limitations in conventional t…
View article: Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications
Paraneoplastic Pemphigus Unveiling Occult Lung Adenocarcinoma: A Rituximab‐Responsive Case With Diagnostic and Therapeutic Implications Open
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder typically associated with hematologic or squamous cell malignancies. Its association with lung adenocarcinoma (LUAD) is exceptionally uncommon, with only sporadic cases reported.…
View article: Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions
Study on Motion Performance and Mooring Tension Response of 16 MW Tension Leg Platform Floating Wind Turbine Under Extreme Environmental Conditions Open
This paper presents a 16 MW typhoon-resistant Tension Leg Platform floating offshore wind turbine (TLP FOWT) designed for the South China Sea. The survivability of the TLP FOWT under extreme environmental conditions is investigated through…
View article: Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup>
Fluoride‐Engineered Electrolyte for Highly Stable and Efficient Alkaline Seawater Electrolysis at 2 A cm <sup>−2</sup> Open
Seawater electrolysis offers an energy‐efficient route for hydrogen production while alleviating freshwater scarcity. However, the presence of Cl − in seawater compromises anode activity and induces severe corrosion, requiring constructing…
View article: The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning
The prognostic value of POD24 for multiple myeloma: a comprehensive analysis based on traditional statistics and machine learning Open
This study suggests that POD24 may be associated to the survival outcomes in multiple myeloma using both traditional statistical and machine learning approaches. Our findings highlight the potential value of POD24 in mortality risk predict…
View article: NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma
NPM1 mediated up – regulation of CXCR4 might drive bortezomib resistance in multiple Myeloma Open
In conclusion, NPM1 might causes BTZ resistance via up-regulating CXCR4 expression in MM and could be served as both a new prognostic biomarker and a promising therapeutic target.
View article: Cuts or carcasses? Diet form affects fecal microbial and animal fiber fractions in a large carnivore, the Asiatic lion
Cuts or carcasses? Diet form affects fecal microbial and animal fiber fractions in a large carnivore, the Asiatic lion Open
The care of exotic felids in zoos involves numerous factors, and the dietary management is currently considered particularly critical. This study investigated the effects of four different dietary regimens on the fecal microbiota and fecal…
View article: Elevated Nitrogen Fertilization Compromises Lodging Resistance in High-Quality, Late-Season Indica Rice Grown in Southern China
Elevated Nitrogen Fertilization Compromises Lodging Resistance in High-Quality, Late-Season Indica Rice Grown in Southern China Open
While nitrogen is essential for rice production, excessive application promotes lodging, threatening yield stability. In this study, we evaluated the impact of three nitrogen application rates (105, 165, and 225 kg ha−1) on yield formation…