Heankel Lyons
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View article: Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions
Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions Open
While specificity of biomolecular interactions is typically understood to require interactions involving ordered structures, several biomolecular condensates exhibit specificity in the absence of apparent structural order. We have previous…
View article: Coactivator condensation drives cardiovascular cell lineage specification
Coactivator condensation drives cardiovascular cell lineage specification Open
During development, cells make switch-like decisions to activate new gene programs specifying cell lineage. The mechanisms underlying these decisive choices remain unclear. Here, we show that the cardiovascular transcriptional coactivator …