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View article: Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy
Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy Open
Hyperactivation of the mTOR pathway during foetal neurodevelopment alters neuron structure and function, leading to focal malformation of cortical development and intractable epilepsy. Recent evidence suggests a role for dysregulated cap-d…
View article: Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome
Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome Open
View article: Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome
Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome Open
Background Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is known to be dysfunctional expression of the maternal allele of ubiquiti…
View article: Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy
Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy Open
SUMMARY Hyperactivation of mTOR signaling during fetal neurodevelopment alters neuron structure and function, leading to focal malformation of cortical development (FMCD) and intractable epilepsy. Recent evidence suggests increased cap-dep…
View article: Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome
Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome Open
Angelman syndrome (AS) is a neurodevelopmental disorder with unique behavioral phenotypes, seizures, and distinctive electroencephalographic (EEG) patterns. Recent studies identified motor, social communication, and learning and memory def…
View article: Additional file 2 of Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome
Additional file 2 of Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman Syndrome Open
Additional file 2. Supplementary file of statistics.
View article: Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus
Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus Open
Status epilepticus (SE) is a prevalent disorder associated with significant morbidity, including the development of epilepsy and mortality. Cardiac arrhythmias (i.e. inappropriate sinus tachycardia and bradycardia, asystole, and atrioventr…
View article: Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome Open
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, microcephaly, and seizures. The genetic cause of AS is the los…
View article: Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice
Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice Open
View article: Wortmannin Attenuates Seizure-Induced Hyperactive PI3K/Akt/mTOR Signaling, Impaired Memory, and Spine Dysmorphology in Rats
Wortmannin Attenuates Seizure-Induced Hyperactive PI3K/Akt/mTOR Signaling, Impaired Memory, and Spine Dysmorphology in Rats Open
Numerous studies have shown epilepsy-associated cognitive deficits, but less is known about the effects of one single generalized seizure. Recent studies demonstrate that a single, self-limited seizure can result in memory deficits and ind…