Heather Corry
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View article: First-in-class small molecule calmodulin pathway modulators attenuate excess p53 activity and correct erythropoietic defects in models of diamond-blackfan anemia (DBA)
First-in-class small molecule calmodulin pathway modulators attenuate excess p53 activity and correct erythropoietic defects in models of diamond-blackfan anemia (DBA) Open
Diamond-Blackfan Anemia (DBA) is a rare congenital bone marrow failure disorder with patients manifesting macrocytic anemia in infancy (Da Costa, et al. Blood 2020; Da Costa, et al. F1000Res. 2018). DBA is caused by germline heterozygous l…
View article: HIV-1 latency reversal agent boosting is not limited by opioid use
HIV-1 latency reversal agent boosting is not limited by opioid use Open
Opioid use may affect the HIV-1 reservoir and its reversal from latency. We studied 47 virally suppressed people with HIV (PWH) and observed that lower concentration of HIV-1 latency reversal agents (LRAs), used with small molecules that d…
View article: HIV-1 latency reversal agent boosting is not limited by opioid use
HIV-1 latency reversal agent boosting is not limited by opioid use Open
The opioid epidemic may impact the HIV-1 reservoir and its reversal from latency in virally suppressed people with HIV (PWH). We studied forty-seven PWH and observed that lowering the concentration of HIV-1 latency reversal agents (LRA), u…
View article: Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019
Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked withi…
View article: Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic Open
In this cohort study, there was no evidence of placental infection or definitive vertical transmission of SARS-CoV-2. Transplacental transfer of anti-SARS-CoV-2 antibodies was inefficient. Lack of viremia and reduced coexpression and coloc…
View article: Liver Fibrosis Index FIB‐4 Is Associated With Mortality in COVID‐19
Liver Fibrosis Index FIB‐4 Is Associated With Mortality in COVID‐19 Open
Coronavirus disease 2019 (COVID‐19) is associated with adverse outcomes, including need for invasive mechanical ventilation and death in people with risk factors. Liver enzyme elevation is commonly seen in this group, but its clinical sign…
View article: SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality
SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality Open
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severit…
View article: SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality
SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality Open
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severit…