Erin Doyle
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View article: Revisiting Pre-Mortem Risk Factors for Mortality in Kittens Less Than 8 Weeks Old After Switching to a Foster Care-Based Kitten Rearing Model
Revisiting Pre-Mortem Risk Factors for Mortality in Kittens Less Than 8 Weeks Old After Switching to a Foster Care-Based Kitten Rearing Model Open
The purpose of this study was to reassess predictors of mortality in underage kittens in a foster-care based kitten rearing model. The medical records of kittens <8 weeks reared in a kitten nursery/foster-care based program in New York Cit…
View article: Hepatocellular carcinoma in patients cured of chronic hepatitis C: Minimal steatosis
Hepatocellular carcinoma in patients cured of chronic hepatitis C: Minimal steatosis Open
Background Successful treatment of hepatitis C reduces liver inflammation and fibrosis; however, patients remain at risk of developing hepatocellular carcinoma (HCC). Aims To identify risk factors for new‐onset HCC in patients cured of hep…
View article: A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function
A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function Open
Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infe…
View article: Pre-mortem risk factors for mortality in kittens less than 8 weeks old at a dedicated kitten nursery
Pre-mortem risk factors for mortality in kittens less than 8 weeks old at a dedicated kitten nursery Open
Objectives Kittens have unique requirements for care in a shelter setting given their higher susceptibility to infectious disease and socialization needs. Significant time and resources are necessary to care for this vulnerable population …
View article: Impact of the Timing of Spay-Neuter Related to Transport on Disease Rates in Relocated Dogs
Impact of the Timing of Spay-Neuter Related to Transport on Disease Rates in Relocated Dogs Open
Companion animal relocation programs are an important method to address geographic and resource disparities in pet overpopulation through transport from areas with high homeless pet populations to areas with high adopter demand. Despite mi…
View article: Individual liver plasmacytoid dendritic cells are capable of producing IFNα and multiple additional cytokines during chronic HCV infection
Individual liver plasmacytoid dendritic cells are capable of producing IFNα and multiple additional cytokines during chronic HCV infection Open
Plasmacytoid dendritic cells (pDCs) are "natural" interferon α (IFNα)-producing cells. Despite their importance to antiviral defense, autoimmunity, and ischemic liver graft injury, because DC subsets are rare and heterogeneous, basic quest…
View article: Newly discovered hepatitis C virus minicores circulate in human blood
Newly discovered hepatitis C virus minicores circulate in human blood Open
Hepatitis C virus (HCV) is one of the most prevalent causes of chronic blood‐borne infections worldwide. Despite developments of highly effective treatments, most infected individuals are unaware of their infection. Approximately 75% of in…
View article: Hepatitis C virus double‐stranded RNA is the predominant form in human liver and in interferon‐treated cells
Hepatitis C virus double‐stranded RNA is the predominant form in human liver and in interferon‐treated cells Open
Hepatitis C virus (HCV) is unique among RNA viruses in its ability to establish chronic infection in the majority of exposed adults. HCV persists in the liver despite interferon (IFN)‐stimulated gene (ISG) induction; robust induction actua…
View article: Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients
Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients Open
Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the pe…
View article: Real-World Sustained Virologic Response Rates of Sofosbuvir-Containing Regimens in Patients Coinfected With Hepatitis C and HIV
Real-World Sustained Virologic Response Rates of Sofosbuvir-Containing Regimens in Patients Coinfected With Hepatitis C and HIV Open
SMV/SOF ± RBV is an effective option with minimal adverse effects for most HIV-positive patients with genotype 1 HCV. SMV should be used with caution in patients with decompensated cirrhosis.
View article: Parallel 34: Experimental Hepatocarcinogenesis
Parallel 34: Experimental Hepatocarcinogenesis Open
327Ashowed enhanced mitochondrial translocation of JNK accompanied by an increase in the release of mitochondrial enzymes, such as apoptosis-inducing factor and endonuclease G, into the cytosol, which is indicative of increased mitochondri…