Heather F. Titterton
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View article: Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain
Macrophages amplify the spontaneous activity of damaged sensory neurons in a human co-culture model of neuropathic pain Open
Neuropathic pain is a highly prevalent condition for which treatments are hampered by low efficacy and dose-limiting side-effects. Injury to the somatosensory nervous system causes maladaptive plasticity that initiates and maintains chroni…
View article: Peripheral nerve injury results in a biased loss of sensory neuron subpopulations
Peripheral nerve injury results in a biased loss of sensory neuron subpopulations Open
There is a rich literature describing the loss of dorsal root ganglion (DRG) neurons following peripheral axotomy, but the vulnerability of discrete subpopulations has not yet been characterised. Furthermore, the extent or even presence of…
View article: Peripheral nerve injury results in a biased loss of sensory neuron sub-populations
Peripheral nerve injury results in a biased loss of sensory neuron sub-populations Open
There is a rich literature describing loss of dorsal root ganglion (DRG) neurons following peripheral axotomy, but the vulnerability of discrete subpopulations has not yet been characterised. Furthermore, the extent and even presence of ne…
View article: Antibodies Against the Gastrin-releasing Peptide Precursor Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse Spinal Dorsal Horn
Antibodies Against the Gastrin-releasing Peptide Precursor Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse Spinal Dorsal Horn Open
Gastrin-releasing peptide (GRP) in the spinal dorsal horn acts on the GRP receptor, and this signalling mechanism has been strongly implicated in itch. However, the source of GRP in the dorsal horn is not fully understood. For example, the…