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View article: Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line
Polyamine Pathway Inhibitor DENSPM Suppresses Lipid Metabolism in Pheochromocytoma Cell Line Open
Pheochromocytomas (PCCs) are tumors arising from chromaffin cells in the adrenal medulla, and paragangliomas (PGLs) are tumors derived from extra-adrenal sympathetic or parasympathetic paraganglia; these tumors are collectively referred to…
View article: Niche for polyamine inhibition in treatment of metastatic pheochromocytoma and paraganglioma
Niche for polyamine inhibition in treatment of metastatic pheochromocytoma and paraganglioma Open
HKG has received royalties from the University of Texas Southwestern Medical Center at Dallas.
View article: Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis
Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis Open
The human adrenal cortex is composed of distinct zones that are the main source of steroid hormone production. The mechanism of adrenocortical cell differentiation into several functionally organized populations with distinctive identities…
View article: Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids Open
Tobacco smoking is the leading cause of preventable death. Numerous reports link smoking in pregnancy with serious adverse outcomes, such as miscarriage, stillbirth, prematurity, low birth weight, perinatal morbidity, and infant mortality.…
View article: MON-199 Targeting Pheochromocytoma/Paraganglioma with Polyamine Inhibitors
MON-199 Targeting Pheochromocytoma/Paraganglioma with Polyamine Inhibitors Open
Background: Pheochromocytomas (PCCs) and paragangliomas (PGLs) are neuroendocrine tumors that are mostly benign. Metastatic disease occurs in about 10% of cases, and for these patients no effective therapies are available. Patients with mu…
View article: SUN-LB053 Metabolic Interaction of SAH and SAM in hPheo1 Cells
SUN-LB053 Metabolic Interaction of SAH and SAM in hPheo1 Cells Open
Pheochromocytomas/paragangliomas (PCC/PGLs) are neuroendocrine tumors, that arise either from the adrenal medulla or sympathetic/parasympathetic chain ganglia. The PCC/PGL tumors that have inactivating mutations in the succinate dehydrogen…
View article: Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors Open
The adrenal glands consist of an outer cortex and an inner medulla, and their primary purposes include hormone synthesis and secretion. The adrenal cortex produces a complex array of steroid hormones, whereas the medulla is part of the sym…
View article: Combined Loss of the GATA4 and GATA6 Transcription Factors in Male Mice Disrupts Testicular Development and Confers Adrenal-Like Function in the Testes
Combined Loss of the GATA4 and GATA6 Transcription Factors in Male Mice Disrupts Testicular Development and Confers Adrenal-Like Function in the Testes Open
The roles of the GATA4 and GATA6 transcription factors in testis development were examined by simultaneously ablating Gata4 and Gata6 with Sf1Cre (Nr5a1Cre). The deletion of both genes resulted in a striking testicular phenotype. Embryonic…