Heather L. Chandler
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View article: Hyperactive PDGFRβ signaling induces cataractogenesis via TGFβ and STAT5-IGF1
Hyperactive PDGFRβ signaling induces cataractogenesis via TGFβ and STAT5-IGF1 Open
PDGFRβ promoted cataractogenesis by modulating pro-fibrotic extracellular matrix changes, likely through TGFβ, Wnt/β-catenin, SOCS2, and the STAT5-IGF1 pathways. Future experiments will delineate the precise role of the STAT5-IGF1 signalin…
View article: Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound Healing
Development of an Ophthalmic Hydrogel to Deliver MG53 and Promote Corneal Wound Healing Open
Background/Objective: A clinical need exists for more effective therapeutics and sustained drug delivery systems to promote ocular surface healing. This study tested the hypothesis that a novel biodegradable, thermoresponsive hydrogel load…
View article: Shroom3 facilitates optic fissure closure via tissue alignment and reestablishment of apical-basal polarity during epithelial fusion
Shroom3 facilitates optic fissure closure via tissue alignment and reestablishment of apical-basal polarity during epithelial fusion Open
Optic cup morphogenesis is a complex process involving cellular behaviors such as epithelial folding, cell shape changes, proliferation, and tissue fusion. Disruptions to these processes can lead to an ocular coloboma, a congenital defect …
View article: Hyperactive Pdgfrβ Signaling Induces Cataractogenesis Via Tgfβ and Stat5-Igf1
Hyperactive Pdgfrβ Signaling Induces Cataractogenesis Via Tgfβ and Stat5-Igf1 Open
View article: Neutrophil pyroptosis regulates corneal wound healing and post‐injury neovascularisation
Neutrophil pyroptosis regulates corneal wound healing and post‐injury neovascularisation Open
Rationale The cornea is a unique structure that maintains its clarity by remaining avascular. Corneal injuries can lead to neovascularisation (CNV) and fibrosis and are the third most common cause of blindness worldwide. Objective Corneal …
View article: Lens epithelial cell response to polymer stiffness and polymer chemistry
Lens epithelial cell response to polymer stiffness and polymer chemistry Open
Posterior capsule opacification (PCO) is the most common complication of cataract surgery, and intraocular lens (IOL) implantation is the standard of care for cataract patients. Induction of postoperative epithelial‐mesenchymal transition …
View article: Insulin facilitates corneal wound healing in the diabetic environment through the RTK-PI3K/Akt/mTOR axis in vitro
Insulin facilitates corneal wound healing in the diabetic environment through the RTK-PI3K/Akt/mTOR axis in vitro Open
View article: Platelet-Derived Growth Factor Receptor β Promotes Cataract Formation
Platelet-Derived Growth Factor Receptor β Promotes Cataract Formation Open
View article: Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice
Recombinant Human MG53 Protein Protects Against Alkaline-Induced Corneal Injuries in Mice Open
Introduction The current study was designed to test the potential role of recombinant human MG53 (rhMG53) protein on protecting against alkaline-induced corneal injury in mice. Materials and Methods A round filter paper with 2-mm diameter …
View article: Methods to Improve Vitamin C Stability in Hydrogel Vitreous Substitutes to Prevent Cataract
Methods to Improve Vitamin C Stability in Hydrogel Vitreous Substitutes to Prevent Cataract Open
View article: Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation
Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation Open
These data demonstrate that LEC proliferation is regulated in part, by the mechanotransduction of stresses induced in the lens capsule and that YAP plays an important role in mechanosensing. These results have important implications for un…
View article: MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents
MG53 promotes corneal wound healing and mitigates fibrotic remodeling in rodents Open
View article: Oxidative Stress Measures of Lipid and DNA Damage in Human Tears
Oxidative Stress Measures of Lipid and DNA Damage in Human Tears Open
We demonstrate feasibility and repeatability of estimating previously unreported tear 8OHdG expression. Seasonal temperature variation and other factors may influence tear lipid peroxidation. Support is demonstrated to suggest lipid damage…
View article: Influence of Substrate Chemical and Mechanical Properties on Lens Epithelial Cell Behavior
Influence of Substrate Chemical and Mechanical Properties on Lens Epithelial Cell Behavior Open
View article: INSULIN FACILITATES IN VITRO CORNEAL WOUND HEALING IN THE DIABETIC ENVIRONMENT
INSULIN FACILITATES IN VITRO CORNEAL WOUND HEALING IN THE DIABETIC ENVIRONMENT Open
View article: Targeting plasma membrane repair in corneal wound healing
Targeting plasma membrane repair in corneal wound healing Open
View article: Subconjunctival antimicrobial poloxamer gel for treatment of corneal ulceration in stranded California sea lions (<i>Zalophus californianus</i>)
Subconjunctival antimicrobial poloxamer gel for treatment of corneal ulceration in stranded California sea lions (<i>Zalophus californianus</i>) Open
Objective Corneal ulcers are commonly encountered in pinnipeds. Prolonged oral antibiotics and topical ophthalmic solutions may not be practical to administer, and novel treatment techniques are desired. Thermodynamic gels are a potential …
View article: Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence
Seasonal Effect on Ocular Sun Exposure and Conjunctival UV Autofluorescence Open
Purpose To evaluate feasibility and repeatability of measures for ocular sun exposure and conjunctival ultraviolet autofluorescence (UVAF), and to test for relationships between the outcomes. Methods Fifty volunteers were seen for two visi…