Heather M. McGee
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View article: Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure
Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure Open
Group 2 innate lymphoid cells (ILC2s) are critical players during type 2 inflammation present in most forms of asthma. ILC2s are tissue-resident cells that produce cytokines IL-5 and IL-13 critical to eosinophilic airway inflammation, mucu…
View article: 89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4 in a preclinical syngeneic breast cancer model
89Zr-anti-CD8 immunoPET visualizes heterogeneous intratumoral CD8+ immune responses to treatment with radiation and anti-CTLA4 in a preclinical syngeneic breast cancer model Open
Anti-CD8 immunoPET facilitates non-invasive, whole-body visualization of immune responses, and syngeneic preclinical models are a crucial tool for studying tumor infiltration of T cells in response to cancer therapies. This study character…
View article: National Institutes of Health Funding to Support Radiation Oncology Research: A Comparative Trend Analysis Over a Decade, 2011-2021
National Institutes of Health Funding to Support Radiation Oncology Research: A Comparative Trend Analysis Over a Decade, 2011-2021 Open
Despite radiation therapy's essential role in multidisciplinary cancer care, NIH, and National Cancer Institute funding to support radiation oncology research has remained disproportionally low over the last decade. These data may be usefu…
View article: Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility
Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility Open
Introduction: To help understand and develop treatments for cancer, it is important to have patient-specific, reliable and physiologically-relevant human culture models. Cells from solid tumors have traditionally been grown in 2-dimensiona…
View article: Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…
View article: Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) avid liver metastases
Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) avid liver metastases Open
View article: Combined Regional Approach of Talimogene laherparepvec and Radiotherapy in the Treatment of Advanced Melanoma
Combined Regional Approach of Talimogene laherparepvec and Radiotherapy in the Treatment of Advanced Melanoma Open
Talimogene laherparepvec (TVEC) is a genetically modified oncolytic herpes simplex virus (HSV-1) that is used for the intralesional treatment of advanced or metastatic melanoma. Given that TVEC produces the granulocyte–macrophage colony-st…
View article: The effects of cell-cell orientation in modeling the hallmarks of lung cancer in vitro
The effects of cell-cell orientation in modeling the hallmarks of lung cancer in vitro Open
To better understand and develop treatments for lung cancer, it is important to have reliable and physiologically relevant culture models. Traditional methods of growing lung cancer cells in two- dimensional (2D) monolayers have limitation…
View article: Atezolizumab plus stereotactic ablative radiotherapy for medically inoperable patients with early-stage non-small cell lung cancer: a multi-institutional phase I trial
Atezolizumab plus stereotactic ablative radiotherapy for medically inoperable patients with early-stage non-small cell lung cancer: a multi-institutional phase I trial Open
Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if ad…
View article: Challenges in synergizing radiotherapy with immunotherapy to unlock the abscopal effect in metastatic NSCLC: A systematic review
Challenges in synergizing radiotherapy with immunotherapy to unlock the abscopal effect in metastatic NSCLC: A systematic review Open
View article: Neonatal exposure to ultraviolet radiation : implications for development and function of the skin immune system
Neonatal exposure to ultraviolet radiation : implications for development and function of the skin immune system Open
Exposure to environmental stimuli, including viruses, bacteria and chemicals, during in early life has the capacity to influence the development of disease in adulthood. Presumably exposure to ultraviolet radiation would represent another …
View article: Advances in Radiation Oncology for Pancreatic Cancer: An Updated Review
Advances in Radiation Oncology for Pancreatic Cancer: An Updated Review Open
This review aims to summarize the recent advances in radiation oncology for pancreatic cancer. A systematic search of the MEDLINE/PubMed database and Clinicaltrials.gov was performed, focusing on studies published within the last 10 years.…
View article: Current landscape of radiation oncology in esophageal cancer: a narrative review
Current landscape of radiation oncology in esophageal cancer: a narrative review Open
Recent advances in radiation oncology may continue to improve outcomes for patients with esophageal cancer.
View article: 508 Generalizability of predictive versus prognostic indicators from published transcriptomic associations with tumor response to immune checkpoint inhibition
508 Generalizability of predictive versus prognostic indicators from published transcriptomic associations with tumor response to immune checkpoint inhibition Open
Background Clinically actionable biomarkers of immune checkpoint inhibitor (ICI) response are currently limited to specific mutation profiling, immunohistochemistry staining for PD-L1, and tumor mutational burden. Use of the latter two are…
View article: Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) Avid Liver Metastases
Feasibility of Biology-guided Radiotherapy (BgRT) Targeting Fluorodeoxyglucose (FDG) Avid Liver Metastases Open
Purpose Biology-guided radiotherapy (BgRT) is a novel radiation delivery approach utilizing fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) imaging performed in real-time to track and direct radiation. Adequate cont…
View article: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R
RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Open
Innate lymphoid cells (ILC) promote lung inflammation in asthma through cytokine production. RNA-binding proteins (RBPs) are critical post-transcriptional regulators, although less is known about RBPs in ILC biology. Here, we demonstrate t…
View article: Hallmarks of Resistance to Immune-Checkpoint Inhibitors
Hallmarks of Resistance to Immune-Checkpoint Inhibitors Open
Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term survival outcomes, are mostly effective in patients with immune-responsive tumors. Most patients with cancer either do not respond to ICIs at all or experien…
View article: Skin-resident innate lymphoid cells converge on a pathogenic effector state
Skin-resident innate lymphoid cells converge on a pathogenic effector state Open
View article: Parallels Between the Antiviral State and the Irradiated State
Parallels Between the Antiviral State and the Irradiated State Open
Improved understanding of host antiviral defense and antitumor immunity have elucidated molecular pathways important to both processes. During viral infection, RNA or DNA in the host cell serves as a danger signal that initiates the antivi…
View article: Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer Open
View article: 75 Generalizability of potential biomarkers of response to CTLA-4 and PD-1 blockade therapy in cancer
75 Generalizability of potential biomarkers of response to CTLA-4 and PD-1 blockade therapy in cancer Open
Background Multiple genomics-based biomarkers of response to immune checkpoint inhibition have been reported or proposed, including tumor mutation/neoantigen frequency, PD-L1 expression, T cell receptor repertoire clonality, interferon gen…
View article: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer Open
View article: The effect of radiation therapy on the objective response and outcomes with nivolumab for hepatocellular carcinoma
The effect of radiation therapy on the objective response and outcomes with nivolumab for hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) remains a leading cause of cancer death worldwide [1]. While current first line therapy for unresectable HCC consists of molecularly targeted agents including sorafen...
View article: P854 Construction of the immune landscape of durable response to checkpoint blockade therapy by integrating publicly available datasets
P854 Construction of the immune landscape of durable response to checkpoint blockade therapy by integrating publicly available datasets Open
Background Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, long-term benefits are only achieved in a small fraction of patients. Understanding the mechanisms underlying ICB activity is key to improving the ef…
View article: Using Behavioral Systems Analysis to Improve Large Scale Change Initiatives in Autism Service Organizations
Using Behavioral Systems Analysis to Improve Large Scale Change Initiatives in Autism Service Organizations Open
View article: Editorial: An Introduction to the Special Section on Organizational Behavior Management in Health & Human Services
Editorial: An Introduction to the Special Section on Organizational Behavior Management in Health & Human Services Open
View article: The Effect of Radiation Therapy on the Objective Response and Outcomes with Nivolumab for Hepatocellular Carcinoma
The Effect of Radiation Therapy on the Objective Response and Outcomes with Nivolumab for Hepatocellular Carcinoma Open
View article: Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop Open
Following publication of the original article [1], the author reported that an author name, Roberta Zappasodi, was missed in the authorship list.
View article: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop Open
Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include …
View article: Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop
Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO–AACR Research Workshop Open
The development of cancer and their response to radiation are intricately linked to the tumor microenvironment (TME) in which they reside. Tumor cells, immune cells, and stromal cells interact with each other and are influenced by the micr…