Heather M. Stapleton
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View article: SAT-241 Impact Of Environmental Chemicals On Gestational Glycemia In A Diverse Cohort In North Carolina
SAT-241 Impact Of Environmental Chemicals On Gestational Glycemia In A Diverse Cohort In North Carolina Open
Disclosure: N. Namasingh: None. A. Alexopoulos: None. J. Hurst: None. M.J. Crowley: None. H. Stapleton: None. R. Hoehn: None. E. Boxer: None. K. Hoffman: None. Introduction: Substantial evidence suggests environmental chemical exposures co…
View article: Silicone Ankle Bands as a Tool to Assess Infant Exposures to Semivolatile Organic Chemicals in Indoor Environments
Silicone Ankle Bands as a Tool to Assess Infant Exposures to Semivolatile Organic Chemicals in Indoor Environments Open
Exposure to organophosphate esters (OPEs), used as flame retardants and plasticizers, is highly variable in the general population, and limited data exist on exposures in young children. This study evaluated the use of silicone ankle bands…
View article: Enduring Autism-like Phenotypes and Deregulated Hypothalamic Prosocial Peptides After Early-Life Exposure to Indoor Flame Retardants in Male C57BL/6 Mice
Enduring Autism-like Phenotypes and Deregulated Hypothalamic Prosocial Peptides After Early-Life Exposure to Indoor Flame Retardants in Male C57BL/6 Mice Open
Background Polybrominated diphenyl ethers (PBDEs) are neuroendocrine disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterize…
View article: Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes
Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes Open
Triphenyl phosphate (TPhP) is a widely used organophosphate flame retardant and plasticizer, raising concerns over its health impacts. This study examined the effects of embryonic TPhP exposure on axial skeletal development and metabolism …
View article: Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice
Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice Open
Polybrominated diphenyl ethers (PBDEs) are synthetic flame retardants once widely used in furniture, electronics, and other consumer products. Although phased out in the early 2000s, their persistence and recycling into new materials have …
View article: Feasibility Study: Silicone Wristbands for Measuring Pesticides and Flame-Retardants in Farming Older Men
Feasibility Study: Silicone Wristbands for Measuring Pesticides and Flame-Retardants in Farming Older Men Open
Background Silicone wristbands can detect exposure to multiple chemicals. In the last decade, health studies have used them to assess environmental exposures, but few have included aging men, particularly those actively working with pestic…
View article: Covariance meta regression, with application to mixtures of chemical exposures
Covariance meta regression, with application to mixtures of chemical exposures Open
The motivation of this article is to improve inferences on the covariation in environmental exposures, motivated by data from a study of Toddlers Exposure to SVOCs in Indoor Environments (TESIE). The challenge is that the sample size is li…
View article: The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study
The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study Open
Background Firefighters are at an increased risk of cancer and other health conditions compared with the general population. However, the specific exposures and mechanisms contributing to these risks are not fully understood. This informat…
View article: Elevated per- and polyfluoroalkyl substances (PFASs) in tap water and serum in a community near an abandoned paper mill
Elevated per- and polyfluoroalkyl substances (PFASs) in tap water and serum in a community near an abandoned paper mill Open
In 2018, elevated concentrations of per- and polyfluoroalkyl substances (PFASs) (1600 ng/L) were discovered in municipal wells, and the groundwater contamination was linked to an abandoned paper mill landfill in southwestern Michigan. From…
View article: Young infants’ exposure to parabens: lotion use as a potential source of exposure
Young infants’ exposure to parabens: lotion use as a potential source of exposure Open
Background Parabens are widely used as antimicrobials in personal care products and pharmaceuticals. While previous studies demonstrate paraben exposure is ubiquitous, data investigating infants’ exposure is limited. Objective We sought to…
View article: Silicone wristbands for assessing personal chemical exposures: impacts of movement on chemical uptake rates
Silicone wristbands for assessing personal chemical exposures: impacts of movement on chemical uptake rates Open
Silicone wristbands are utilized for evaluating personal exposures to organic chemicals. This study shows that the movement of individuals can enhance rates of chemical uptake on these wristbands.
View article: The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study (Preprint)
The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study (Preprint) Open
BACKGROUND Firefighters are at an increased risk of cancer and other health conditions compared with the general population. However, the specific exposures and mechanisms contributing to these risks are not fully understood. This informa…
View article: Silicone Wristbands as a Personal Passive Sampler to Evaluate Indoor Exposure to Volatile and Non-volatile PFASs
Silicone Wristbands as a Personal Passive Sampler to Evaluate Indoor Exposure to Volatile and Non-volatile PFASs Open
Exposure to per- and polyfluoroalkyl substances (PFASs) primarily occurs via consumption of contaminated drinking water and food; however, individuals can also be exposed dermally and via inhalation indoors. This study developed an analyti…
View article: Wristband Personal Passive Samplers and Suspect Screening Methods Highlight Gender Disparities in Chemical Exposures
Wristband Personal Passive Samplers and Suspect Screening Methods Highlight Gender Disparities in Chemical Exposures Open
Wristband personal samplers enable human exposure assessments for a diverse range of chemical contaminants and exposure settings with a previously unattainable scale and cost-effectiveness. Paired with nontargeted analyses, wristbands can …
View article: Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Scoping Review
Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Scoping Review Open
Purpose of Review Environmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early environmental exposures have been limited in size and diversity, hindering power and general…
View article: Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse<i>Caenorhabditis elegans</i>strains
Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse<i>Caenorhabditis elegans</i>strains Open
Background There are >14,500 structurally diverse per- and polyfluoroalkyl substances (PFAS). Despite knowledge that these “forever chemicals” are in 99% of humans, mechanisms of toxicity and adverse health effects are incompletely known. …
View article: Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research
Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research Open
Human health is intimately connected and tied to the health of our environment and ecosystem, with only a very small fraction of the risk for chronic diseases explained by genetics alone. Companion animals are prone to disease types that a…
View article: Flame Retardant Exposure in Vehicles Is Influenced by Use in Seat Foam and Temperature
Flame Retardant Exposure in Vehicles Is Influenced by Use in Seat Foam and Temperature Open
Flame retardants (FRs) are added to vehicles to meet flammability standards, such as US Federal Motor Vehicle Safety Standard FMVSS 302. However, an understanding of which FRs are being used, sources in the vehicle, and implications for hu…
View article: Arachidonic Acid Metabolites in Self-Collected Biospecimens following Campfire Exposure: Exploring Non-invasive Biomarkers of Wildfire Health Effects
Arachidonic Acid Metabolites in Self-Collected Biospecimens following Campfire Exposure: Exploring Non-invasive Biomarkers of Wildfire Health Effects Open
Climate change has contributed to increased frequency and intensity of wildfire. Studying its acute effects is limited due to unpredictable nature of wildfire occurrence, which necessitates readily deployable techniques to collect biospeci…
View article: Opportunities in Assessing and Regulating Organohalogen Flame Retardants (OFRs) as a Class in Consumer Products
Opportunities in Assessing and Regulating Organohalogen Flame Retardants (OFRs) as a Class in Consumer Products Open
A class-based approach for regulating OFRs can be successful. Expanding the use of read-across and the use of New Approach Methodologies (NAMs) in assessing and regulating existing chemicals was considered as a necessary part of the class-…
View article: OR06-02 Placental Distribution Of Polybrominated Diphenyl Ethers (Pbdes) And Thyroid Hormones Across Gestation In PBDE-exposed Wistar Rats
OR06-02 Placental Distribution Of Polybrominated Diphenyl Ethers (Pbdes) And Thyroid Hormones Across Gestation In PBDE-exposed Wistar Rats Open
Disclosure: S. Gaballah: None. B. Horman: None. G. St Armour: None. K. Hoffman: None. H.B. Patisaul: None. H. Stapleton: None. In utero exposure to polybrominated diphenyl ethers (PBDEs) has been linked to adverse pregnancy and fetal healt…